KEGG   Homo sapiens (human): 4294
Entry
4294              CDS       T01001                                 
Symbol
MAP3K10, MEKK10, MLK2, MST
Name
(RefSeq) mitogen-activated protein kinase kinase kinase 10
  KO
K04418  mitogen-activated protein kinase kinase kinase 10 [EC:2.7.11.25]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa05016  Huntington disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06461  Huntington disease
nt06526  MAPK signaling
  Element
N00992  Mutation-caused aberrant Htt to TNF-JNK signaling pathway
N01594  MLK-JNK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    4294 (MAP3K10)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05016 Huntington disease
    4294 (MAP3K10)
   05022 Pathways of neurodegeneration - multiple diseases
    4294 (MAP3K10)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    4294 (MAP3K10)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     4294 (MAP3K10)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  MLK family
   4294 (MAP3K10)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase SH3_9 SH3_1 SH3_2 Pkinase_fungal RNase_Y_N OmpH
Other DBs
NCBI-GeneID: 4294
NCBI-ProteinID: NP_002437
OMIM: 600137
HGNC: 6849
Ensembl: ENSG00000130758
UniProt: Q02779
Structure
Position
19:40191426..40215575
AA seq 954 aa
MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWT
GQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGE
EVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGG
ALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLA
DTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGE
VPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVI
EQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLR
RREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGF
EHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSR
GGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHT
PIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPP
ARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRG
LSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSP
PAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPP
EPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWK
LVSFGRTLTISPPSRPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH
NT seq 2865 nt   +upstreamnt  +downstreamnt
atggaggaggaggagggggcggtggccaaggagtggggcacgacccccgcggggcccgtc
tggaccgcggtgttcgactacgaggcggcgggcgacgaggagctgaccctgcggaggggc
gatcgcgtccaggtgctttcccaagactgtgcggtgtccggcgacgagggctggtggacc
gggcagctccccagcggccgcgtgggcgtcttccccagcaactacgtggcccccggcgcc
cccgctgcacccgcgggcctccagctgccccaggagatccccttccacgagctgcagcta
gaggagatcatcggtgtggggggctttggcaaggtctatcgggccctgtggcgtggcgag
gaggtggcagtcaaggccgcccggctggaccctgagaaggacccggcagtgacagcggag
caggtgtgccaggaagcccggctctttggagccctgcagcaccccaacataattgccctt
aggggcgcctgcctcaaccccccacacctctgcctagtgatggagtatgcccggggtggt
gcactgagcagggtgctggcaggtcgccgggtgccacctcacgtgctggtcaactgggct
gtgcaggtggcccggggcatgaactacctacacaatgatgcccctgtgcccatcatccac
cgggacctcaagtccatcaacatcctgatcctggaggccatcgagaaccacaacctcgca
gacacggtgctcaagatcacggacttcggcctcgcccgcgagtggcacaagaccaccaag
atgagcgctgcggggacctacgcctggatggcgccggaggttatccgtctctccctcttc
tccaaaagcagtgatgtctggagcttcggggtgctgctgtgggagctgctgacgggggag
gtcccctaccgtgagatcgacgccttggccgtggcgtatggcgtggctatgaataagctg
acgctgcccattccctccacgtgccccgagccctttgcccgcctcctggaggaatgctgg
gacccagacccccacgggcggccagatttcggtagcatcttgaagcggcttgaagtcatc
gaacagtcagccctgttccagatgccactggagtccttccactcgctgcaggaagactgg
aagctggagattcagcacatgtttgatgaccttcggaccaaggagaaggagcttcggagc
cgtgaggaggagctgctgcgggcggcacaggagcagcgcttccaggaggagcagctgcgg
cggcgggagcaggagctggcagaacgtgagatggacatcgtggaacgggagctgcacctg
ctcatgtgccagctgagccaggagaagccccgggtccgcaagcgcaagggcaacttcaag
cgcagccgcctgctcaagctgcgggaaggcggcagccacatcagcctgccctctggcttt
gagcataagatcacagtccaggcctctccaactctggataagcggaaaggatccgatggg
gccagcccccctgcaagccccagcatcatcccccggctgagggccattcgcctgactccc
gtggactgtggtggcagcagcagtggcagcagcagtggaggaagtgggacatggagccgc
ggtgggcccccaaagaaggaagaactggtcgggggcaagaagaagggacgaacgtggggg
cccagctccaccctgcagaaggagcgggtgggaggagaggagaggctgaaggggctgggg
gaaggaagcaaacagtggtcatcaagtgcccccaacctgggcaagtcccccaaacacaca
cccatcgcccctggctttgccagcctcaatgagatggaggagttcgcggaggcagaggat
ggaggcagcagcgtgcccccttccccctactcgaccccgtcctacctctcagtgccactg
cctgccgagccctccccgggggcgcgggcgccgtgggagccgacgccgtccgcgcccccc
gctcggtggggacacggcgcccggcggcgctgcgacctggcgctgctaggctgcgccacg
ctgctgggggctgtgggcctgggcgccgacgtggccgaggcgcgcgcggccgacggtgag
gagcagcggcgctggctcgacggcctcttctttccccgcgccggccgcttcccgcggggc
ctcagcccacccgcgcgtccccacggccgccgcgaagacgtgggccccggcctgggcctg
gcgccctcggccaccctcgtgtcgctgtcgtccgtgtccgactgcaactccacgcgttca
ctgctgcgctctgacagtgacgaggccgcaccggccgcgccctccccaccaccctccccg
cccgcgcccacacccacgccctcgcccagcaccaaccccctggtggacctggagctggag
agcttcaagaaggacccccgccagtcgctcacgcccacccacgtcacggctgcatgcgct
gtgagccgcgggcaccggcggacgccatcggacggggcgctggggcagcgggggccgccc
gagcccgcgggccatggccctggccctcgtgaccttctggacttcccccgcctgcccgac
ccccaggccctgttcccagcccgccgccggccccctgagttcccaggccgccccaccacc
ctgacctttgccccgagacctcggccggctgccagtcgcccccgcttggacccctggaaa
ctggtctccttcggccggacactcaccatctcgcctcccagcaggccagacactccggag
agccctgggccccccagcgtgcagcccacactgctggacatggacatggaggggcagaac
caagacagcacagtgcccctgtgcggggcccacggctcccactaa

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Network (4)   
   KEGG NETWORK (4)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (26)   
   KEGG ORTHOLOGY (1)   
   RefGene (20)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (11)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (9)   
DNA sequence (17)   
   RefSeq(nuc) (9)   
   GenBank (4)   
   EMBL (4)   
3D Structure (1)   
   PDB (1)   
Protein domain (8)   
   Pfam (8)   
All databases (76)   

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