KEGG   Homo sapiens (human): 4677
Entry
4677              CDS       T01001                                 
Symbol
NARS1, ASNRS, NARS, NEDMILEG, NEDMILG
Name
(RefSeq) asparaginyl-tRNA synthetase 1
  KO
K01893  asparaginyl-tRNA synthetase [EC:6.1.1.22]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00970  Aminoacyl-tRNA biosynthesis
Disease
H02709  Neurodevelopmental disorder with aminoacyl-tRNA synthetase defect
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   00970 Aminoacyl-tRNA biosynthesis
    4677 (NARS1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes [BR:hsa01007]
    4677 (NARS1)
  09182 Protein families: genetic information processing
   03016 Transfer RNA biogenesis [BR:hsa03016]
    4677 (NARS1)
Enzymes [BR:hsa01000]
 6. Ligases
  6.1  Forming carbon-oxygen bonds
   6.1.1  Ligases forming aminoacyl-tRNA and related compounds
    6.1.1.22  asparagine---tRNA ligase
     4677 (NARS1)
Amino acid related enzymes [BR:hsa01007]
 Aminoacyl-tRNA synthetase
  Class II (A)
   4677 (NARS1)
Transfer RNA biogenesis [BR:hsa03016]
 Eukaryotic type
  Aminoacyl-tRNA synthetases (AARSs)
   Other AARSs
    4677 (NARS1)
 Prokaryotic type
    4677 (NARS1)
SSDB
Motif
Pfam: tRNA-synt_2 AsnRS_N tRNA_anti-codon
Other DBs
NCBI-GeneID: 4677
NCBI-ProteinID: NP_004530
OMIM: 108410
HGNC: 7643
Ensembl: ENSG00000134440
UniProt: O43776
Structure
Position
18:complement(57600656..57621836)
AA seq 548 aa
MVLAELYVSDREGSDATGDGTKEKPFKTGLKALMTVGKEPFPTIYVDSQKENERWNVISK
SQLKNIKKMWHREQMKSESREKKEAEDSLRREKNLEEAKKITIKNDPSLPEPKCVKIGAL
EGYRGQRVKVFGWVHRLRRQGKNLMFLVLRDGTGYLQCVLADELCQCYNGVLLSTESSVA
VYGMLNLTPKGKQAPGGHELSCDFWELIGLAPAGGADNLINEESDVDVQLNNRHMMIRGE
NMSKILKARSMVTRCFRDHFFDRGYYEVTPPTLVQTQVEGGATLFKLDYFGEEAFLTQSS
QLYLETCLPALGDVFCIAQSYRAEQSRTRRHLAEYTHVEAECPFLTFDDLLNRLEDLVCD
VVDRILKSPAGSIVHELNPNFQPPKRPFKRMNYSDAIVWLKEHDVKKEDGTFYEFGEDIP
EAPERLMTDTINEPILLCRFPVEIKSFYMQRCPEDSRLTESVDVLMPNVGEIVGGSMRIF
DSEEILAGYKREGIDPTPYYWYTDQRKYGTCPHGGYGLGLERFLTWILNRYHIRDVCLYP
RFVQRCTP
NT seq 1647 nt   +upstreamnt  +downstreamnt
atggtgctagcagagctgtacgtctctgaccgagagggaagcgatgccacgggagatgga
accaaggagaaaccatttaaaacaggtctaaaggctttgatgacagtagggaaagaacca
tttcctaccatttacgtagattcacaaaaagaaaatgagaggtggaatgttatttctaaa
tcacagttgaagaacattaaaaagatgtggcatagggaacaaatgaagagtgaatcccgg
gaaaagaaagaggcagaagatagtttacgaagagaaaagaacctggaagaagcaaagaag
attaccattaaaaatgatccaagtctcccagagccaaaatgtgtgaagattggtgcgtta
gaaggatatagaggccaaagagtaaaggtgtttggctgggtccacaggctgcgcaggcaa
ggaaagaatttaatgtttctggtgttgcgagatggtacaggttatcttcagtgtgtcttg
gcggatgagttgtgtcagtgctacaatggagttctcttgtccacggagagcagtgttgca
gtgtatggaatgctaaatcttaccccaaagggcaagcaggctccaggtggccatgagctg
agttgtgacttctgggaactaattgggttggcccctgctggaggagctgacaacctgatc
aatgaggagtctgacgttgatgtccagctcaacaacagacacatgatgatccgaggagaa
aacatgtccaaaatcctaaaagcacgatccatggtcaccaggtgctttagagatcacttc
tttgatagggggtactatgaagttactcctccaacattagtgcaaacacaagtagaaggt
ggtgccacactcttcaagcttgactattttggggaagaggcatttttgactcaatcctct
cagttgtacttggagacctgcctcccagccctgggagatgttttttgtattgctcagtca
taccgggcagagcagtccagaacacgaaggcacctggctgagtacactcacgtggaagct
gagtgtcctttcctgacttttgacgacctcctgaaccggttggaggacttggtttgtgat
gtggtagatcgaatattgaagtcacctgcagggagcatagtgcatgagctcaacccgaac
tttcagccccccaaacggcctttcaaacggatgaactattcagatgctatcgtttggcta
aaagaacatgatgtaaagaaagaagatggaactttctatgaatttggagaagatatccca
gaagctcctgagagactgatgacagacaccattaatgaaccaatcttgctgtgtcgattt
cctgtggagatcaagtccttctacatgcagcgatgtcctgaggattcccgtcttactgaa
tctgtcgacgtgttgatgcccaatgttggtgagattgtgggaggctcaatgcgtatcttt
gatagtgaagaaatactggcaggttataaaagggaagggattgaccccactccctattac
tggtatacggatcagagaaaatacggtacatgtccccatggaggatatggcttgggcttg
gaacgattcttaacgtggattctgaataggtatcacatccgagacgtgtgcttataccct
cgatttgtccagcgttgcacgccataa

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (4)   
   KEGG DISEASE (1)   
   OMIM (3)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (28)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (13)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (25)   
   RefSeq(nuc) (3)   
   GenBank (11)   
   EMBL (11)   
3D Structure (3)   
   PDB (3)   
Protein domain (3)   
   Pfam (3)   
All databases (82)   

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