KEGG   Homo sapiens (human): 4967
Entry
4967              CDS       T01001                                 
Symbol
OGDH, AKGDH, E1k, E1o, KGD1, OGDC, OGDH-E1, OGDH2, OGDHD
Name
(RefSeq) oxoglutarate dehydrogenase
  KO
K00164  2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00020  Citrate cycle (TCA cycle)
hsa00785  Lipoic acid metabolism
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
hsa01210  2-Oxocarboxylic acid metabolism
Module
hsa_M00009  Citrate cycle (TCA cycle, Krebs cycle)
hsa_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Network
nt06031  Citrate cycle and pyruvate metabolism
nt06032  Lipoic acid metabolism
  Element
N01609  Citrate cycle, second carbon oxidation 1
Disease
H01022  Diseases of the tricarboxylic acid cycle
H02006  Alpha-ketoglutarate dehydrogenase complex deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    4967 (OGDH)
  09108 Metabolism of cofactors and vitamins
   00785 Lipoic acid metabolism
    4967 (OGDH)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.2  oxoglutarate dehydrogenase (succinyl-transferring)
     4967 (OGDH)
SSDB
Motif
Pfam: E1_dh OxoGdeHyase_C Transket_pyr 2-oxogl_dehyd_N GGA_N-GAT
Other DBs
NCBI-GeneID: 4967
NCBI-ProteinID: NP_002532
OMIM: 613022
HGNC: 8124
Ensembl: ENSG00000105953
UniProt: Q02218 B4E3E9
Structure
Position
7:44606627..44709066
AA seq 1023 aa
MFHLRTCAAKLRPLTASQTVKTFSQNRPAAARTFQQIRCYSAPVAAEPFLSGTSSNYVEE
MYCAWLENPKSVHKSWDIFFRNTNAGAPPGTAYQSPLPLSRGSLAAVAHAQSLVEAQPNV
DKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLGFYGLDES
DLDKVFHLPTTTFIGGQESALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIRQKFET
PGIMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIIDKSSEN
GVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGDVKYHLGMYHRRINR
VTDRNITLSLVANPSHLEAADPVVMGKTKAEQFYCGDTEGKKVMSILLHGDAAFAGQGIV
YETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNSDDP
EAVMYVCKVAAEWRSTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKPVLQKY
AELLVSQGVVNQPEYEEEISKYDKICEEAFARSKDEKILHIKHWLDSPWPGFFTLDGQPR
SMSCPSTGLTEDILTHIGNVASSVPVENFTIHGGLSRILKTRGEMVKNRTVDWALAEYMA
FGSLLKEGIHIRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPYTVCNSSL
SEYGVLGFELGFAMASPNALVLWEAQFGDFHNTAQCIIDQFICPGQAKWVRQNGIVLLLP
HGMEGMGPEHSSARPERFLQMCNDDPDVLPDLKEANFDINQLYDCNWVVVNCSTPGNFFH
VLRRQILLPFRKPLIIFTPKSLLRHPEARSSFDEMLPGTHFQRVIPEDGPAAQNPENVKR
LLFCTGKVYYDLTRERKARDMVGQVAITRIEQLSPFPFDLLLKEVQKYPNAELAWCQEEH
KNQGYYDYVKPRLRTTISRAKPVWYAGRDPAAAPATGNKKTHLTELQRLLDTAFDLDVFK
NFS
NT seq 3072 nt   +upstreamnt  +downstreamnt
atgtttcatttaaggacttgtgctgctaagttgaggccattgacggcttcccagactgtt
aagacattttcacaaaacagaccagcagcagctaggacatttcaacagattcggtgctat
tctgcacctgttgctgctgagccctttctcagtgggactagttcgaactatgtggaggag
atgtactgtgcttggctggaaaaccccaaaagtgtacataagtcatgggacatttttttt
cgcaacacgaatgccggagccccaccgggcactgcctaccagagtccccttcccctgagc
cgaggctccctggctgctgtggcccatgcacagtccctggtagaagcacagcccaacgtg
gacaagctcgtggaggaccacctggcagtgcagtcgctcatcagggcatatcagatacga
gggcaccatgtagcacagctggaccccctggggattttggatgctgatctggactcctcc
gtgcccgctgacattatctcatccacagacaaacttgggttctatggcctggatgagtct
gacctcgacaaggtcttccacttgcccaccaccactttcatcgggggacaggaatcagca
cttcctctgcgggagatcatccgtcggctggagatggcctactgccagcatattggggtg
gagttcatgttcatcaatgacctggagcagtgccagtggatccggcagaagtttgagacc
cctgggatcatgcagttcacaaatgaggagaaacggaccctgctggccaggcttgtgcgg
tccaccaggtttgaggagttcctacagcggaagtggtcctctgagaagcgctttggtcta
gaaggctgcgaggtactgatccctgccctcaagaccatcattgacaagtctagtgagaat
ggcgtggactacgtgatcatgggcatgccacacagagggcggctgaacgtgcttgcaaat
gtcatcaggaaggagctggaacagatcttctgtcaattcgattcaaagctggaggcagct
gatgagggctccggagatgtgaagtaccacctgggcatgtatcaccgcaggatcaatcgt
gtcaccgacaggaacattaccttgtccttggtggccaacccttcccaccttgaggccgct
gaccccgtggtgatgggcaagaccaaagccgaacagttttactgtggcgacactgaaggg
aaaaaggtcatgtccatcctgttgcatggggatgctgcatttgctggccagggcattgtg
tacgagaccttccacctcagcgacctgccatcctacacaactcatggcaccgtgcacgtg
gtcgtcaacaaccagatcggcttcaccaccgaccctcggatggcccgctcctccccctac
cccactgacgtggcccgagtggtgaatgcccccattttccacgtgaactcagatgacccc
gaggctgtcatgtacgtgtgcaaagtggcggccgagtggaggagcaccttccacaaggac
gtggttgtcgatttggtgtgttaccggcgcaacggccacaacgagatggatgagcccatg
ttcacgcagccgctcatgtacaagcagatccgcaagcagaagcctgtgttacagaagtac
gctgagctgctggtgtcgcagggtgtggtcaaccagcctgagtatgaggaggaaatttcc
aagtatgataagatctgtgaggaagcttttgccagatctaaagatgagaagatcttgcac
attaagcactggctggactctccctggcctggcttcttcaccctggacgggcagcccagg
agcatgtcctgcccctccacgggtctgacggaggatattctgacacacatcgggaatgtg
gctagttctgtgcctgtggaaaactttactattcatggagggctgagccggatcttgaag
actcgtggggaaatggtgaagaaccggactgtggactgggctctagcggagtacatggcg
tttggctcgctcctgaaggagggcatccacattcggctgagcggccaggacgtggagcgg
ggcacattcagccaccgccaccatgtgctccatgaccagaatgtggacaagagaacctgc
atccccatgaaccatctctggcccaatcaggccccctatactgtgtgcaacagctcactg
tctgagtacggcgtgctgggctttgagctgggcttcgccatggccagtcctaatgccctg
gtcctctgggaagcccaatttggtgacttccacaacacggcccagtgtatcatcgaccag
ttcatctgcccgggacaagccaagtgggtgcggcagaatggcatcgtgttgctgctgccc
catggcatggagggcatgggtccagaacattcctccgcccgcccagagcggttcttgcag
atgtgcaacgatgacccagatgtcctgccagaccttaaagaagccaacttcgacatcaat
cagctatatgactgcaattgggttgttgtcaactgctccactcctggcaacttcttccac
gtgctacgacgccagatcctgctgccattccggaagccgttaattatcttcacccccaaa
tccctgttgcgccaccccgaggccagatccagctttgatgagatgcttccaggaacccac
ttccagcgggtgatcccagaagatggccctgcagctcagaacccagaaaatgtcaaaagg
cttctcttctgcaccggcaaagtgtattatgacctcacccgggagcgcaaagcacgcgac
atggtggggcaggtggccatcacaaggattgagcagctgtcgccattcccctttgacctc
ctgctgaaggaggtgcagaagtaccccaatgctgagctggcctggtgccaggaggagcac
aagaaccaaggctactatgactacgtgaagccaagacttcggaccaccatcagccgcgcc
aagcccgtctggtatgccggccgggacccagcggctgctccagccaccggcaacaagaag
acccacctgacggagctgcagcgcctcctggacacggccttcgacctggacgtcttcaag
aacttctcgtag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (5)   
   KEGG MODULE (2)   
Network (3)   
   KEGG NETWORK (3)   
Disease (4)   
   KEGG DISEASE (2)   
   OMIM (2)   
Chemical substance (11)   
   KEGG COMPOUND (11)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG REACTION (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (19)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (16)   
DNA sequence (58)   
   RefSeq(nuc) (16)   
   GenBank (21)   
   EMBL (21)   
3D Structure (2)   
   PDB (2)   
Protein domain (5)   
   Pfam (5)   
All databases (128)   

Download RDF
DBGET integrated database retrieval system