KEGG   Homo sapiens (human): 50506
Entry
50506             CDS       T01001                                 
Symbol
DUOX2, LNOX2, NOXEF2, P138-TOX, TDH6, THOX2
Name
(RefSeq) dual oxidase 2
  KO
K13411  dual oxidase [EC:1.6.3.1 1.11.1.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04918  Thyroid hormone synthesis
Network
nt06322  TRH-TSH-TH signaling
  Element
N00793  TSH-DUOX2-TG signaling pathway
N00795  DUOX2-generated H2O2 production
Disease
H00251  Thyroid dyshormonogenesis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04918 Thyroid hormone synthesis
    50506 (DUOX2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    50506 (DUOX2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.6  Acting on NADH or NADPH
   1.6.3  With oxygen as acceptor
    1.6.3.1  NAD(P)H oxidase (H2O2-forming)
     50506 (DUOX2)
Membrane trafficking [BR:hsa04131]
 Others
  NADPH oxidases (Nox) and associated proteins
   NADPH oxidases
    50506 (DUOX2)
SSDB
Motif
Pfam: An_peroxidase NAD_binding_6 FAD_binding_8 Ferric_reduct EF-hand_1 EF-hand_7 EF-hand_8 EF-hand_6 EF-hand_5 NAD_binding_1 Rv0078B
Other DBs
NCBI-GeneID: 50506
NCBI-ProteinID: NP_054799
OMIM: 606759
HGNC: 13273
Ensembl: ENSG00000140279
UniProt: Q9NRD8
Position
15:complement(45092650..45114172)
AA seq 1548 aa
MLRARPEALMLLGALLTGSLGPSGNQDALSLPWEVQRYDGWFNNLRHHERGAVGCRLQRR
VPANYADGVYQALEEPQLPNPRRLSNAATRGIAGLPSLHNRTVLGVFFGYHVLSDVVSVE
TPGCPAEFLNIRIPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLD
GSAIYGSSHSWSDALRSFSGGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAF
GAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYE
WLPSFLQKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKG
FQSSQALRVCNNYWIRENPNLNSTQEVNELLLGMASQISELEDNIVVEDLRDYWPGPGKF
SRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVLEATAALYNQDLS
QLELLLGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIRNTTL
RDVLVAVINIDPSALQPNVFVWHKGAPCPQPKQLTTDGLPQCAPLTVLDFFEGSSPGFAI
TIIALCCLPLVSLLLSGVVAYFRGREHKKLQKKLKESVKKEAAKDGVPAMEWPGPKERSS
PIIIQLLSDRCLQVLNRHLTVLRVVQLQPLQQVNLILSNNRGCRTLLLKIPKEYDLVLLF
SSEEERGAFVQQLWDFCVRWALGLHVAEMSEKELFRKAVTKQQRERILEIFFRHLFAQVL
DINQADAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLS
FREFLDILVVFMKGSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQL
AEVVESMFRESGFQDKEELTWEDFHFMLRDHDSELRFTQLCVKGGGGGGNGIRDIFKQNI
SCRVSFITRTPGERSHPQGLGPPAPEAPELGGPGLKKRFGKKAAVPTPRLYTEALQEKMQ
RGFLAQKLQQYKRFVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVGI
ILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRWIAMAAVVLAIL
HSAGHAVNVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLLVLA
IMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPTFHIYFLVPAIIYGGD
KLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHPFTL
TSAPHEDTLSLHIRAVGPWTTRLREIYSSPKGNGCAGYPKLYLDGPFGEGHQEWHKFEVS
VLVGGGIGVTPFASILKDLVFKSSLGSQMLCKKIYFIWVTRTQRQFEWLADIIQEVEEND
HQDLVSVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFN
SLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLVNRQDRAHFMHHYENF
NT seq 4647 nt   +upstreamnt  +downstreamnt
atgctccgtgcaagaccagaggcactgatgctcctgggagctcttctgactggatccctg
ggtccatcgggcaatcaggacgcactctcactgccctgggaagtgcagcgctatgacggc
tggtttaacaacctgaggcaccacgagcgtggtgctgttggctgccggttgcagcgccgc
gtaccagccaattacgccgacggtgtgtatcaggctctggaggagccgcagctgcccaac
ccgcgccggctcagcaacgcagccacgcggggcatagccggcctgccgtcgctccacaac
cgcaccgtactgggggtcttctttggctaccatgttctttccgacgtggtgagcgtggaa
acgcccggttgccccgccgagttcctcaacatccgcatcccacctggagaccccgtgttc
gaccccgaccagcgcggggacgtggtgctgcccttccagaggagccgctgggaccccgag
accggacggagtcccagcaacccccgggacctggccaaccaggtgacgggctggctggac
ggcagcgccatctatggctcctcgcactcctggagcgacgcgctgcggagcttctcgggg
ggacagctggcgtcggggcccgaccccgctttcccccgagactcgcagaaccccctgctc
atgtgggcggcgcccgaccccgccaccgggcagaacgggccccgggggctgtacgccttc
ggggcagagagagggaaccgggaacccttcctgcaggcgctgggcctgctctggttccgc
taccacaacctgtgggcgcagaggctggcccgccagcacccagactgggaggacgaggag
ctgttccagcacgcacgcaagagggtcatcgccacctaccagaacatcgctgtgtatgag
tggctgcccagcttcctgcagaaaacactcccggagtatacaggataccgtcctttccta
gaccccagcatctccccggaatttgtggtggcctctgagcagttcttctctaccatggtg
ccccctggtgtctacatgagaaatgccagctgtcatttccggaaggtcctgaacaagggt
tttcaaagctcccaagctctcagggtctgcaacaactactggattcgggagaaccccaat
ctgaacagtacccaggaggtgaatgagctgctgctgggaatggcctcccagatttcggag
ttggaggacaacatagtggttgaagatctgagggattactggcctggccctggcaaattc
tcccgtacagactatgtggccagcagcatccaacgtggccgagatatggggctgcccagc
tatagccaggccctgctggcctttgggctggacatcccaaggaactggagtgatctcaac
cctaatgtggacccccaggtgctggaggccacagctgccctgtacaaccaggacctatcc
cagctagagctgctccttggggggctcctggagagccatggggaccctggacccctgttc
agtgccattgtcctcgaccagtttgtacggctgcgggatggtgaccgctactggtttgag
aacaccaggaatgggctgttctccaagaaggagattgaagacatccgaaataccaccctg
cgggacgtgctggtcgctgttatcaacattgaccccagtgccctgcagcccaatgtcttt
gtctggcataaaggtgcaccctgccctcaacctaagcagctcacaactgacggcctgccc
cagtgtgcacccctgactgtgcttgacttctttgaaggcagcagccctggttttgccatc
accatcattgctctctgctgccttcccttagtgagtctgcttctctctggagtggtggcc
tatttccggggccgagaacacaagaagctacaaaagaaactcaaagagagcgtgaagaag
gaagcagccaaagatggagtgccagcgatggagtggccaggccccaaggagaggagcagt
cccatcatcatccagctgctgtcagacaggtgtctgcaggtcctgaacaggcatctcact
gtgctccgtgtggtccagctgcagcctctgcagcaggtcaacctcatcctgtccaacaac
cgaggatgccgcaccctgctgctcaagatccctaaggagtatgacctggtgctgctgttt
agttctgaagaggaacggggcgcctttgtgcagcagctatgggacttctgcgtgcgctgg
gctctgggcctccatgtggctgagatgagcgagaaggagctatttaggaaggctgtgaca
aagcagcagcgggaacgcatcctggagatcttcttcagacacctttttgctcaggtgctg
gacatcaaccaggccgacgcagggaccctgcccctggactcctcccagaaggtgcgggag
gccctgacctgcgagctgagcagggccgagtttgccgagtccctgggcctcaagccccag
gacatgtttgtggagtccatgttctctctggctgacaaggatggcaatggctacctgtcc
ttccgagagttcctggacatcctggtggtcttcatgaaaggctccccagaggataagtcc
cgtctaatgtttaccatgtatgacctggatgagaatggcttcctctccaaggacgaattc
ttcaccatgatgcgatccttcatcgagatctccaacaactgcctgtccaaggcccagctg
gccgaggtggtggagtctatgttccgggagtcgggattccaggacaaggaggagctgaca
tgggaggattttcacttcatgctgcgggaccatgacagcgagctccgcttcacgcagctc
tgtgtcaaaggtggaggtggaggtggaaatggtattagagatatctttaaacaaaacatc
agctgtcgagtctcgttcatcactcggacacctggggagcgctcccacccccagggactg
gggccccctgccccagaagccccagagctgggaggccctggactgaagaagaggtttggc
aaaaaggcagcagtgcccactccccggctgtacacagaggcgctgcaagagaagatgcag
cgaggcttcctagcccaaaagctgcagcagtacaagcgcttcgtggagaactaccggagg
cacatcgtgtgtgtggcaatcttctcggccatctgtgttggcgtgtttgcagatcgtgct
tactactatggctttgcctcgccaccctcggacattgcacagaccaccctcgtgggcatc
atcctgtcacgaggcacggcggccagcgtctccttcatgttctcttatatcttgctcacc
atgtgccgcaacctcataaccttcctgcgagagactttcctcaaccgctatgtgcctttt
gatgccgcagtggacttccaccgctggatcgccatggctgctgttgtcctggccattttg
cacagtgctggccacgcagtcaatgtctacatcttctcagtcagcccactcagcctgctg
gcctgcatattccccaacgtctttgtgaatgatgggtccaagcttccccagaagttctat
tggtggttcttccagaccgtcccaggtatgacaggtgtgcttctgctcctggtcctggcc
atcatgtatgtcttcgcctcccaccacttccgccgccgcagcttccggggcttctggctg
acccaccacctctacatcctgctctatgccctgctcatcatccatggcagctatgctctg
atccagctgcccactttccacatctacttcctggtcccggcaatcatctatggaggtgac
aagctggtgagcctgagccggaagaaggtggagatcagcgtggtgaaggcggagctgctg
ccctcaggagtgacctacctgcaattccagaggccccaaggctttgagtacaagtcagga
cagtgggtgcggatcgcctgcctggctctggggaccaccgagtaccaccccttcacactg
acctccgcgccccatgaggacacactcagcctgcacatccgggcagtggggccctggacc
actcgcctcagggagatctactcatccccaaagggcaatggctgtgctggatacccaaag
ctgtaccttgatggaccgtttggagagggccatcaggagtggcataaatttgaggtgtca
gtgttggtgggagggggcattggggtcaccccctttgcctccatcctcaaagacctggtc
ttcaagtcatccttgggcagccaaatgctgtgtaagaagatctacttcatctgggtgaca
cggacccagcgtcagtttgagtggctggctgacatcatccaagaggtggaggagaacgac
caccaggacctggtgtctgtgcacatttatgtcacccagctggctgagaagttcgacctc
aggaccaccatgctatacatctgcgagcggcacttccagaaagtgctgaaccggagtctg
ttcacgggcctgcgctccatcacccactttggccgtccccccttcgagcccttcttcaac
tccctgcaggaggtccacccacaggtgcgcaagatcggggtgttcagctgcggccctcca
ggaatgaccaagaatgtagagaaggcctgtcagctcgtcaacaggcaggaccgagcccac
ttcatgcaccactatgagaacttctga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (3)   
   KEGG NETWORK (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (31)   
   KEGG ORTHOLOGY (1)   
   RefGene (25)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (12)   
   RefSeq(nuc) (2)   
   GenBank (5)   
   EMBL (5)   
Protein domain (11)   
   Pfam (11)   
All databases (70)   

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