KEGG   Homo sapiens (human): 540
Entry
540               CDS       T01001                                 
Symbol
ATP7B, PWD, WC1, WD, WND
Name
(RefSeq) ATPase copper transporting beta
  KO
K17686  P-type Cu+ transporter [EC:7.2.2.8]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01524  Platinum drug resistance
hsa04978  Mineral absorption
Disease
H00210  Wilson disease
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09154 Digestive system
   04978 Mineral absorption
    540 (ATP7B)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    540 (ATP7B)
Enzymes [BR:hsa01000]
 7. Translocases
  7.2  Catalysing the translocation of inorganic cations
   7.2.2  Linked to the hydrolysis of a nucleoside triphosphate
    7.2.2.8  P-type Cu+ transporter
     540 (ATP7B)
SSDB
Motif
Pfam: HMA E1-E2_ATPase Hydrolase HMA_2 Hydrolase_3 Hydrolase_6 HAD_2 HAD
Other DBs
NCBI-GeneID: 540
NCBI-ProteinID: NP_000044
OMIM: 606882
HGNC: 870
Ensembl: ENSG00000123191
UniProt: P35670 B7ZLR4
Structure
Position
13:complement(51932669..52012132)
AA seq 1465 aa
MPEQERQITAREGASRKILSKLSLPTRAWEPAMKKSFAFDNVGYEGGLDGLGPSSQVATS
TVRILGMTCQSCVKSIEDRISNLKGIISMKVSLEQGSATVKYVPSVVCLQQVCHQIGDMG
FEASIAEGKAASWPSRSLPAQEAVVKLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSN
QEAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKVAPLSLGPIDIERLQSTNPKRPLSSAN
QNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVK
YDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCST
TLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDM
GFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQ
STRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPL
EIAQFIQDLGFEAAVMEDYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALA
TSKALVKFDPEIIGPRDIIKIIEEIGFHASLAQRNPNAHHLDHKMEIKQWKKSFLCSLVF
GIPVMALMIYMLIPSNEPHQSMVLDHNIIPGLSILNLIFFILCTFVQLLGGWYFYVQAYK
SLRHRSANMDVLIVLATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWL
EHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFP
VDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDTTLAQIV
KLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKH
ISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHK
IKTVMFDKTGTITHGVPRVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCK
EELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNEAGSLPAEKDAV
PQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQ
EAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGK
KVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRR
IRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPD
LERYEAQAHGHMKPLTASQVSVHIGMDDRWRDSPRATPWDQVSYVSQVSLSSLTSDKPSR
HSAAADDDGDKWSLLLNGRDEEQYI
NT seq 4398 nt   +upstreamnt  +downstreamnt
atgcctgagcaggagagacagatcacagccagagaaggggccagtcggaaaatcttatct
aagctttctttgcctacccgtgcctgggaaccagcaatgaagaagagttttgcttttgac
aatgttggctatgaaggtggtctggatggcctgggcccttcttctcaggtggccaccagc
acagtcaggatcttgggcatgacttgccagtcatgtgtgaagtccattgaggacaggatt
tccaatttgaaaggcatcatcagcatgaaggtttccctggaacaaggcagtgccactgtg
aaatatgtgccatcggttgtgtgcctgcaacaggtttgccatcaaattggggacatgggc
ttcgaggccagcattgcagaaggaaaggcagcctcctggccctcaaggtccttgcctgcc
caggaggctgtggtcaagctccgggtggagggcatgacctgccagtcctgtgtcagctcc
attgaaggcaaggtccggaaactgcaaggagtagtgagagtcaaagtctcactcagcaac
caagaggccgtcatcacttatcagccttatctcattcagcccgaagacctcagggaccat
gtaaatgacatgggatttgaagctgccatcaagagcaaagtggctcccttaagcctggga
ccaattgatattgagcggttacaaagcactaacccaaagagacctttatcttctgctaac
cagaattttaataattctgagaccttggggcaccaaggaagccatgtggtcaccctccaa
ctgagaatagatggaatgcattgtaagtcttgcgtcttgaatattgaagaaaatattggc
cagctcctaggggttcaaagtattcaagtgtccttggagaacaaaactgcccaagtaaag
tatgacccttcttgtaccagcccagtggctctgcagagggctatcgaggcacttccacct
gggaattttaaagtttctcttcctgatggagccgaagggagtgggacagatcacaggtct
tccagttctcattcccctggctccccaccgagaaaccaggtccagggcacatgcagtacc
actctgattgccattgccggcatgacctgtgcatcctgtgtccattccattgaaggcatg
atctcccaactggaaggggtgcagcaaatatcggtgtctttggccgaagggactgcaaca
gttctttataatccctctgtaattagcccagaagaactcagagctgctatagaagacatg
ggatttgaggcttcagtcgtttctgaaagctgttctactaaccctcttggaaaccacagt
gctgggaattccatggtgcaaactacagatggtacacctacatctgtgcaggaagtggct
ccccacactgggaggctccctgcaaaccatgccccggacatcttggcaaagtccccacaa
tcaaccagagcagtggcaccgcagaagtgcttcttacagatcaaaggcatgacctgtgca
tcctgtgtgtctaacatagaaaggaatctgcagaaagaagctggtgttctctccgtgttg
gttgccttgatggcaggaaaggcagagatcaagtatgacccagaggtcatccagcccctc
gagatagctcagttcatccaggacctgggttttgaggcagcagtcatggaggactacgca
ggctccgatggcaacattgagctgacaatcacagggatgacctgcgcgtcctgtgtccac
aacatagagtccaaactcacgaggacaaatggcatcacttatgcctccgttgcccttgcc
accagcaaagcccttgttaagtttgacccggaaattatcggtccacgggatattatcaaa
attattgaggaaattggctttcatgcttccctggcccagagaaaccccaacgctcatcac
ttggaccacaagatggaaataaagcagtggaagaagtctttcctgtgcagcctggtgttt
ggcatccctgtcatggccttaatgatctatatgctgatacccagcaacgagccccaccag
tccatggtcctggaccacaacatcattccaggactgtccattctaaatctcatcttcttt
atcttgtgtacctttgtccagctcctcggtgggtggtacttctacgttcaggcctacaaa
tctctgagacacaggtcagccaacatggacgtgctcatcgtcctggccacaagcattgct
tatgtttattctctggtcatcctggtggttgctgtggctgagaaggcggagaggagccct
gtgacattcttcgacacgccccccatgctctttgtgttcattgccctgggccggtggctg
gaacacttggcaaagagcaaaacctcagaagccctggctaaactcatgtctctccaagcc
acagaagccaccgttgtgacccttggtgaggacaatttaatcatcagggaggagcaagtc
cccatggagctggtgcagcggggcgatatcgtcaaggtggtccctgggggaaagtttcca
gtggatgggaaagtcctggaaggcaataccatggctgatgagtccctcatcacaggagaa
gccatgccagtcactaagaaacccggaagcactgtaattgcggggtctataaatgcacat
ggctctgtgctcattaaagctacccacgtgggcaatgacaccactttggctcagattgtg
aaactggtggaagaggctcagatgtcaaaggcacccattcagcagctggctgaccggttt
agtggatattttgtcccatttatcatcatcatgtcaactttgacgttggtggtatggatt
gtaatcggttttatcgattttggtgttgttcagagatactttcctaaccccaacaagcac
atctcccagacagaggtgatcatccggtttgctttccagacgtccatcacggtgctgtgc
attgcctgcccctgctccctggggctggccacgcccacggctgtcatggtgggcaccggg
gtggccgcgcagaacggcatcctcatcaagggaggcaagcccctggagatggcgcacaag
ataaagactgtgatgtttgacaagactggcaccattacccatggcgtccccagggtcatg
cgggtgctcctgctgggggatgtggccacactgcccctcaggaaggttctggctgtggtg
gggactgcggaggccagcagtgaacaccccttgggcgtggcagtcaccaaatactgtaaa
gaggaacttggaacagagaccttgggatactgcacggacttccaggcagtgccaggctgt
ggaattgggtgcaaagtcagcaacgtggaaggcatcctggcccacagtgagcgccctttg
agtgcaccggccagtcacctgaatgaggctggcagccttcccgcagaaaaagatgcagtc
ccccagaccttctctgtgctgattggaaaccgtgagtggctgaggcgcaacggtttaacc
atttctagcgatgtcagtgacgctatgacagaccacgagatgaaaggacagacagccatc
ctggtggctattgacggtgtgctctgtgggatgatcgcaatcgcagacgctgtcaagcag
gaggctgccctggctgtgcacacgctgcagagcatgggtgtggacgtggttctgatcacg
ggggacaaccggaagacagccagagctattgccacccaggttggcatcaacaaagtcttt
gcagaggtgctgccttcgcacaaggtggccaaggtccaggagctccagaataaagggaag
aaagtcgccatggtgggggatggggtcaatgactccccggccttggcccaggcagacatg
ggtgtggccattggcaccggcacggatgtggccatcgaggcagccgacgtcgtccttatc
agaaatgatttgctggatgtggtggctagcattcacctttccaagaggactgtccgaagg
atacgcatcaacctggtcctggcactgatttataacctggttgggatacccattgcagca
ggtgtcttcatgcccatcggcattgtgctgcagccctggatgggctcagcggccatggca
gcctcctctgtgtctgtggtgctctcatccctgcagctcaagtgctataagaagcctgac
ctggagaggtatgaggcacaggcgcatggccacatgaagcccctgacggcatcccaggtc
agtgtgcacataggcatggatgacaggtggcgggactcccccagggccacaccatgggac
caggtcagctatgtcagccaggtgtcgctgtcctccctgacgtccgacaagccatctcgg
cacagcgctgcagcagacgatgatggggacaagtggtctctgctcctgaatggcagggat
gaggagcagtacatctga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   RefGene (14)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (44)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (41)   
DNA sequence (77)   
   RefSeq(nuc) (41)   
   GenBank (18)   
   EMBL (18)   
3D Structure (13)   
   PDB (13)   
Protein domain (8)   
   Pfam (8)   
All databases (171)   

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