KEGG   Homo sapiens (human): 55157
Entry
55157             CDS       T01001                                 
Symbol
DARS2, ASPRS, LBSL, MT-ASPRS, mtAspRS
Name
(RefSeq) aspartyl-tRNA synthetase 2, mitochondrial
  KO
K01876  aspartyl-tRNA synthetase [EC:6.1.1.12]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00970  Aminoacyl-tRNA biosynthesis
Disease
H00871  Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   00970 Aminoacyl-tRNA biosynthesis
    55157 (DARS2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes [BR:hsa01007]
    55157 (DARS2)
  09182 Protein families: genetic information processing
   03016 Transfer RNA biogenesis [BR:hsa03016]
    55157 (DARS2)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    55157 (DARS2)
Enzymes [BR:hsa01000]
 6. Ligases
  6.1  Forming carbon-oxygen bonds
   6.1.1  Ligases forming aminoacyl-tRNA and related compounds
    6.1.1.12  aspartate---tRNA ligase
     55157 (DARS2)
Amino acid related enzymes [BR:hsa01007]
 Aminoacyl-tRNA synthetase
  Class II (A)
   55157 (DARS2)
Transfer RNA biogenesis [BR:hsa03016]
 Eukaryotic type
  Aminoacyl-tRNA synthetases (AARSs)
   Multi-aminoacyl-tRNA synthetase complex (MSC)
    55157 (DARS2)
 Prokaryotic type
   Other AARSs
    55157 (DARS2)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial transcription and translation factors
   Other mitochondrial DNA transcription and translation factors
    55157 (DARS2)
SSDB
Motif
Pfam: tRNA-synt_2 GAD tRNA_anti-codon
Other DBs
NCBI-GeneID: 55157
NCBI-ProteinID: NP_060592
OMIM: 610956
HGNC: 25538
Ensembl: ENSG00000117593
UniProt: Q6PI48 Q9H9J7
Structure
Position
1:173824673..173858546
AA seq 645 aa
MYFPSWLSQLYRGLSRPIRRTTQPIWGSLYRSLLQSSQRRIPEFSSFVVRTNTCGELRSS
HLGQEVTLCGWIQYRRQNTFLVLRDFDGLVQVIIPQDESAASVKKILCEAPVESVVQVSG
TVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVKKTEALRLQYRYLDLRS
FQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGGAKEFLVPSREPGKFYSLP
QSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVDQTGIQSLIEGL
LQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMKIIDISDVFRNTEIGFLQDAL
SKPHGTVKAICIPEGAKYLKRKDIESIRNFAADHFNQEILPVFLNANRNWNSPVANFIME
SQRLELIRLMETQEEDVVLLTAGEHNKACSLLGKLRLECADLLETRGVVLRDPTLFSFLW
VVDFPLFLPKEENPRELESAHHPFTAPHPSDIHLLYTEPKKARSQHYDLVLNGNEIGGGS
IRIHNAELQRYILATLLKEDVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRD
VIAFPKSFRGHDLMSNTPDSVPPEELKPYHIRVSKPTDSKAERAH
NT seq 1938 nt   +upstreamnt  +downstreamnt
atgtacttcccttcttggttaagtcagctgtacaggggtttatccagacccatcagaagg
accacccaaccgatctggggttctctctacagaagtctgttgcagagttcacagaggaga
attccagaattcagtagctttgttgtccggaccaacacatgtggagagttgcgttcgtct
cacttaggccaagaagtcaccttgtgtggatggattcagtaccgaaggcaaaacacattc
ttggtcctaagagatttcgatgggcttgttcaagttatcattccccaggatgagtcggca
gcctctgtgaagaagattttatgtgaagcccctgtggaatctgtggtgcaagtgtctggt
acagtcatttcccgtcctgcaggacaagagaatccaaaaatgccaacaggtgagattgaa
atcaaagttaaaacagctgagcttctgaatgcctgcaagaagctgccctttgaaattaag
aacttcgtgaagaaaacagaggctcttcggttgcagtatcgctacttagacttgcgtagt
ttccaaatgcagtataacctgcgactgaggtcccagatggtcatgaaaatgcgggaatat
ctctgtaatctgcatgggtttgtggatatagaaacccccacattgtttaagaggacccca
gggggtgccaaagagtttttagtaccatccagggaacctggaaagttttattctctccct
cagagtcctcaacagtttaagcaacttctgatggttggcggtttagacagatattttcag
gttgcccgatgttatcgagatgaaggttcaagaccagacagacagcctgagtttactcag
attgacatagagatgtcatttgtagaccagactgggatccagagtttaattgagggtttg
ctccagtattcctggcccaatgacaaagatcctgtggttgttccttttcctactatgact
tttgctgaggtgctggccacctatggaactgataaacctgacactcgctttggaatgaag
attatagatatcagtgatgtgtttagaaacacagagattggatttcttcaagatgcactt
agtaagccccatggaactgtgaaagccatatgtatccctgaaggagcaaaatacttaaaa
aggaaagacattgaatccattagaaactttgcagctgaccattttaatcaggaaatctta
cctgtattccttaacgccaatagaaactggaattctccagttgctaatttcataatggag
tcacaaagactggaattaatcagactaatggagacccaagaggaagatgtggtcctacta
actgctggagagcacaataaagcatgctctttgttaggaaaattacgactggaatgtgct
gaccttctagaaacaagaggagtggtgctccgtgaccccactctgttctctttcctttgg
gtggtagatttcccactcttcctgcccaaggaggaaaatcccagagagctggaatcggcc
caccacccatttactgctccccaccccagtgacatacatctcctgtacactgagcccaaa
aaggcccgtagccaacactatgacttggttttaaatggcaatgaaataggaggtggttca
attcgaattcacaatgcagagctgcagcgttatatcctggcaaccttactaaaggaggat
gtgaaaatgctctcccatctgctccaggctttagattatggggcaccccctcatggagga
attgccttagggttagacagactgatatgccttgtcactggatctccaagcatcagagat
gtcatagccttcccaaagtccttccggggacatgacctcatgagcaataccccagattct
gtccctcctgaggaactgaagccctatcatatccgagtctccaagccaacagactccaaa
gcagaaagagctcattga

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Ontology (5)   
   KEGG BRITE (5)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (15)   
   RefSeq(nuc) (3)   
   GenBank (6)   
   EMBL (6)   
3D Structure (1)   
   PDB (1)   
Protein domain (3)   
   Pfam (3)   
All databases (57)   

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