KEGG   Homo sapiens (human): 55753
Entry
55753             CDS       T01001                                 
Symbol
OGDHL, YOBELN
Name
(RefSeq) oxoglutarate dehydrogenase L
  KO
K00164  2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00020  Citrate cycle (TCA cycle)
hsa00785  Lipoic acid metabolism
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
hsa01210  2-Oxocarboxylic acid metabolism
Module
hsa_M00009  Citrate cycle (TCA cycle, Krebs cycle)
hsa_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Network
nt06031  Citrate cycle and pyruvate metabolism
nt06032  Lipoic acid metabolism
  Element
N01609  Citrate cycle, second carbon oxidation 1
Disease
H02562  Yoon-Bellen neurodevelopmental syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    55753 (OGDHL)
  09108 Metabolism of cofactors and vitamins
   00785 Lipoic acid metabolism
    55753 (OGDHL)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.2  oxoglutarate dehydrogenase (succinyl-transferring)
     55753 (OGDHL)
SSDB
Motif
Pfam: E1_dh OxoGdeHyase_C Transket_pyr 2-oxogl_dehyd_N GGA_N-GAT
Other DBs
NCBI-GeneID: 55753
NCBI-ProteinID: NP_001334748
OMIM: 617513
HGNC: 25590
Ensembl: ENSG00000197444
UniProt: Q9ULD0
Position
10:complement(49734641..49762379)
AA seq 1010 aa
MSQLRLLPSRLGVQAARLLAAHDVPVFGWRSRSSGPPATFPSSKGGGGSSYMEEMYFAWL
ENPQSVHKSWDSFFREASEEAFSGSAQPRPPSVVHESRSAVSSRTKTSKLVEDHLAVQSL
IRAYQIRGHHVAQLDPLGILDADLDSFVPSDLITTIDKLAFYDLQEADLDKEFQLPTTTF
IGGSENTLSLREIIRRLENTYCQHIGLEFMFINDVEQCQWIRQKFETPGVMQFSSEEKRT
LLARLVRSMRFEDFLARKWSSEKRFGLEGCEVMIPALKTIIDKSSEMGIENVILGMPHRG
RLNVLANVIRKDLEQIFCQFDPKLEAADEGSGDVKYHLGMYHERINRVTNRNITLSLVAN
PSHLEAVDPVVQGKTKAEQFYRGDAQGKKVMSILVHGDAAFAGQGVVYETFHLSDLPSYT
TNGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNADDPEAVIYVCSVAAEW
RNTFNKDVVVDLVCYRRRGHNEMDEPMFTQPLMYKQIHRQVPVLKKYADKLIAEGTVTLQ
EFEEEIAKYDRICEEAYGRSKDKKILHIKHWLDSPWPGFFNVDGEPKSMTCPATGIPEDM
LTHIGSVASSVPLEDFKIHTGLSRILRGRADMTKNRTVDWALAEYMAFGSLLKEGIHVRL
SGQDVERGTFSHRHHVLHDQEVDRRTCVPMNHLWPDQAPYTVCNSSLSEYGVLGFELGYA
MASPNALVLWEAQFGDFHNTAQCIIDQFISTGQAKWVRHNGIVLLLPHGMEGMGPEHSSA
RPERFLQMSNDDSDAYPAFTKDFEVSQLYDCNWIVVNCSTPANYFHVLRRQILLPFRKPL
IIFTPKSLLRHPEAKSSFDQMVSGTSFQRVIPEDGAAARAPEQVQRLIFCTGKVYYDLVK
ERSSQDLEEKVAITRLEQISPFPFDLIKQEAEKYPGAELAWCQEEHKNMGYYDYISPRFM
TILRRARPIWYVGRDPAAAPATGNRNTHLVSLKKFLDTAFNLQAFEGKTF
NT seq 3033 nt   +upstreamnt  +downstreamnt
atgagtcagctgaggctgctgccgtcccgtcttggggtacaggctgcgaggctcctggct
gcacatgacgtcccggtgtttggctggcgcagcaggtcctccgggccaccggccaccttc
ccaagcagcaaaggtggaggcggctccagttacatggaggagatgtacttcgcctggttg
gaaaacccccagagtgtccacaagtcctgggacagcttcttcagggaagccagcgaggaa
gccttttctggctctgctcagccacggcccccttctgttgtccatgagagcaggtctgca
gtctcaagtcggaccaagaccagcaaattggtggaggaccacctggctgtgcagtccctg
atccgggcctaccagatccggggtcaccatgtggcccagctggaccccctgggcattctg
gatgcagacctggactcctttgtgccctcagacttgatcacaaccattgataaactggcc
ttctatgaccttcaggaggctgaccttgataaggagttccagctgccgacaaccaccttc
attgggggctctgaaaacaccctctctctgcgggagatcattcggcgcctggagaacacc
tactgccagcacattggcctggagttcatgttcatcaacgatgtggagcagtgccagtgg
atccggcagaagtttgagacccctggtgtgatgcagttctccagcgaggagaagcggacc
ctgctggcccggctagtgcgctccatgaggtttgaagacttcctggcccggaaatggtcc
tcagagaagcggtttggcctggagggctgtgaagtgatgattcctgccctcaagaccatc
atcgacaaatccagcgagatggggattgagaatgtcatcttggggatgccacacagggga
aggctgaacgtgctggccaacgtgatccgcaaggacctggagcagatcttctgccagttt
gaccccaagctggaggcggcggacgagggctccggggatgtcaagtaccacctgggcatg
taccatgagaggatcaaccgcgtcaccaaccggaacatcactctgtcgctggttgccaac
ccctcccacctggaggcagtggaccctgtggtgcaggggaagacaaaggcagagcagttc
taccgtggagatgcccagggcaagaaggtcatgtccatcctggttcatggggacgccgcc
tttgctggccagggcgtggtatatgagaccttccacctgagcgacctgccctcctacacg
accaatggtaccgtgcacgtcgtcgtcaacaaccagattggattcaccacagacccccga
atggcccgctcctcaccatacccgaccgacgtggcccgggtggtcaatgcgcctatcttc
catgtgaatgccgatgacccagaggctgtgatatatgtgtgcagtgtggcagccgaatgg
agaaacactttcaacaaagatgttgtcgtggacctggtctgttaccgccggcgtggccac
aatgagatggacgagcccatgttcacccagccgctcatgtacaagcagatccacagacag
gtgcctgtgctgaagaagtacgcagacaagctgattgccgagggcacagtcaccctgcag
gagtttgaggaagaaattgccaaatacgaccggatctgtgaggaggcttatggcaggtcc
aaggataaaaagattctgcatataaagcactggttggactccccctggcctggcttcttc
aacgtagatggggagcccaagagcatgacatgcccagccacggggatccctgaggacatg
ctcacccacatcggcagtgtggccagctctgtgcccctggaggactttaagatccacact
ggcctctctcgcattctgcggggccgtgcggacatgaccaagaaccggacggtggactgg
gcgttggcagagtacatggcctttggctccctgctgaaggaaggcatccacgtgcggctc
agcgggcaggatgtggagaggggcacattcagtcaccggcaccatgttctccatgaccag
gaggttgaccgcaggacgtgtgtgcctatgaatcatctctggcctgaccaggccccgtac
accgtgtgcaacagctccctctcggagtacggagtcctgggctttgagctgggctatgcc
atggccagccccaatgccctggtcctctgggaggcccagtttggggacttccacaacacg
gcccagtgcatcatcgaccagttcatcagcaccggccaggccaagtgggtgcggcataat
ggcattgtgctgctgctgccccatggcatggaaggcatgggcccagagcactcgtcagcg
aggcccgaaaggttcctgcagatgagcaatgatgactcggatgcctaccctgcattcacc
aaggacttcgaggtgagccagctctatgactgcaactggatcgtggtcaactgctccaca
ccggccaactacttccacgtgctgcgccggcagatcctgctgcccttccgcaagccgctg
attatcttcacacctaaatctctgctgaggcacccagaggccaagtccagctttgaccaa
atggtatccgggaccagcttccagcgggtgattcctgaagatggggccgcagcacgggcc
cctgagcaggtgcagcggctcatcttctgcacgggaaaggtgtactatgacctggtgaag
gagcggagcagccaggacctggaggagaaagtggccatcacgcgcctggagcagatctct
ccattccccttcgacctgatcaagcaggaggcagagaagtacccaggtgcggagctggcc
tggtgtcaggaggagcacaagaacatgggctactatgactacatcagcccacgcttcatg
accatcctgaggcgcgcacggcccatatggtatgttggccgggacccagcggctgcacca
gccacaggaaacaggaacactcacctggtgtcactgaagaagtttctggatactgccttc
aatctccaggcctttgagggcaagacattttag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (5)   
   KEGG MODULE (2)   
Network (3)   
   KEGG NETWORK (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (11)   
   KEGG COMPOUND (11)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG REACTION (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (17)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (15)   
DNA sequence (50)   
   RefSeq(nuc) (20)   
   GenBank (15)   
   EMBL (15)   
Protein domain (5)   
   Pfam (5)   
All databases (116)   

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