KEGG   Homo sapiens (human): 5660
Entry
5660              CDS       T01001                                 
Symbol
PSAP, GLBA, PARK24, PSAPD, SAP1, SAP2
Name
(RefSeq) prosaposin
  KO
K12382  saposin
Organism
hsa  Homo sapiens (human)
Pathway
hsa00600  Sphingolipid metabolism
hsa04142  Lysosome
Network
nt06014  Sphingolipid degradation
  Element
N00642  Saposin stimulation of GBA and GALC
N00643  Loss of saposin stimulation
Disease
H00057  Parkinson disease
H00126  Gaucher disease
H00127  Metachromatic leukodystrophy
H00135  Krabbe disease
H00423  Sphingolipidosis
H01239  Combined SAP deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00600 Sphingolipid metabolism
    5660 (PSAP)
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    5660 (PSAP)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    5660 (PSAP)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   5660 (PSAP)
SSDB
Motif
Pfam: SapB_1 SapB_2 SapA Saposin Helicase_C_3 ApoLp-III Xpo1
Other DBs
NCBI-GeneID: 5660
NCBI-ProteinID: NP_002769
OMIM: 176801
HGNC: 9498
Ensembl: ENSG00000197746
UniProt: P07602
Structure
Position
10:complement(71816298..71851251)
AA seq 524 aa
MYALFLLASLLGAALAGPVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVKS
LPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILDI
IKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLLY
PQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADI
CKNYISQYSEIAIQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELVE
PIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEV
VDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCEVCKKLVGYLD
RNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIG
ACPSAHKPLLGTEKCIWGPSYWCQNTETAAQCNAVEHCKRHVWN
NT seq 1575 nt   +upstreamnt  +downstreamnt
atgtacgccctcttcctcctggccagcctcctgggcgcggctctagccggcccggtcctt
ggactgaaagaatgcaccaggggctcggcagtgtggtgccagaatgtgaagacggcgtcc
gactgcggggcagtgaagcactgcctgcagaccgtttggaacaagccaacagtgaaatcc
cttccctgcgacatatgcaaagacgttgtcaccgcagctggtgatatgctgaaggacaat
gccactgaggaggagatccttgtttacttggagaagacctgtgactggcttccgaaaccg
aacatgtctgcttcatgcaaggagatagtggactcctacctccctgtcatcctggacatc
attaaaggagaaatgagccgtcctggggaggtgtgctctgctctcaacctctgcgagtct
ctccagaagcacctagcagagctgaatcaccagaagcagctggagtccaataagatccca
gagctggacatgactgaggtggtggcccccttcatggccaacatccctctcctcctctac
cctcaggacggcccccgcagcaagccccagccaaaggataatggggacgtttgccaggac
tgcattcagatggtgactgacatccagactgctgtacggaccaactccacctttgtccag
gccttggtggaacatgtcaaggaggagtgtgaccgcctgggccctggcatggccgacata
tgcaagaactatatcagccagtattctgaaattgctatccagatgatgatgcacatgcaa
cccaaggagatctgtgcgctggttgggttctgtgatgaggtgaaagagatgcccatgcag
actctggtccccgccaaagtggcctccaagaatgtcatccctgccctggaactggtggag
cccattaagaagcacgaggtcccagcaaagtctgatgtttactgtgaggtgtgtgaattc
ctggtgaaggaggtgaccaagctgattgacaacaacaagactgagaaagaaatactcgac
gcttttgacaaaatgtgctcgaagctgccgaagtccctgtcggaagagtgccaggaggtg
gtggacacgtacggcagctccatcctgtccatcctgctggaggaggtcagccctgagctg
gtgtgcagcatgctgcacctctgctctggcacgcggctgcctgcactgaccgttcacgtg
actcagccaaaggacggtggcttctgcgaagtgtgcaagaagctggtgggttatttggat
cgcaacctggagaaaaacagcaccaagcaggagatcctggctgctcttgagaaaggctgc
agcttcctgccagacccttaccagaagcagtgtgatcagtttgtggcagagtacgagccc
gtgctgatcgagatcctggtggaggtgatggatccttccttcgtgtgcttgaaaattgga
gcctgcccctcggcccataagcccttgttgggaactgagaagtgtatatggggcccaagc
tactggtgccagaacacagagacagcagcccagtgcaatgctgtcgagcattgcaaacgc
catgtgtggaactag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Network (3)   
   KEGG NETWORK (3)   
Disease (12)   
   KEGG DISEASE (6)   
   OMIM (6)   
Genome (1)   
   KEGG GENOME (1)   
Gene (70)   
   KEGG ORTHOLOGY (1)   
   RefGene (17)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (47)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (53)   
   RefSeq(nuc) (3)   
   GenBank (25)   
   EMBL (25)   
3D Structure (17)   
   PDB (17)   
Protein domain (7)   
   Pfam (7)   
All databases (172)   

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