KEGG   Homo sapiens (human): 57154
Entry
57154             CDS       T01001                                 
Symbol
SMURF1
Name
(RefSeq) SMAD specific E3 ubiquitin protein ligase 1
  KO
K04678  E3 ubiquitin ligase SMURF1/2 [EC:2.3.2.26]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04120  Ubiquitin mediated proteolysis
hsa04137  Mitophagy - animal
hsa04144  Endocytosis
hsa04340  Hedgehog signaling pathway
hsa04350  TGF-beta signaling pathway
hsa04520  Adherens junction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    57154 (SMURF1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    57154 (SMURF1)
   04350 TGF-beta signaling pathway
    57154 (SMURF1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    57154 (SMURF1)
   04137 Mitophagy - animal
    57154 (SMURF1)
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    57154 (SMURF1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    57154 (SMURF1)
   04121 Ubiquitin system [BR:hsa04121]
    57154 (SMURF1)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    57154 (SMURF1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.26  HECT-type E3 ubiquitin transferase
     57154 (SMURF1)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    57154 (SMURF1)
 Autophagy
  Mitophagy
   Other mitophagy associated  proteins
    57154 (SMURF1)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  HECT type E3
   57154 (SMURF1)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Parkin-independent mechanism factors
    57154 (SMURF1)
SSDB
Motif
Pfam: HECT WW C2
Other DBs
NCBI-GeneID: 57154
NCBI-ProteinID: NP_065162
OMIM: 605568
HGNC: 16807
Ensembl: ENSG00000198742
UniProt: Q9HCE7
Structure
Position
7:complement(99027440..99144108)
AA seq 757 aa
MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA
PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY
EQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSV
NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS
EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR
PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS
INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV
WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI
EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR
WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLP
KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
NT seq 2274 nt   +upstreamnt  +downstreamnt
atgtcgaaccccgggacacgcaggaacggctccagcatcaagatccgtctgacagtgtta
tgtgccaagaaccttgcaaagaaagacttcttcaggctccctgacccttttgcaaagatt
gtcgtggatgggtctgggcagtgccactcaaccgacactgtgaaaaacacattggaccca
aagtggaaccagcactatgatctatatgttgggaaaacggattcgataaccattagcgtg
tggaaccataagaaaattcacaagaaacagggagctggcttcctgggctgtgtgcggctg
ctctccaatgccatcagcagattaaaagataccggataccagcgtttggatctatgcaaa
ctaaacccctcagatactgatgcagttcgtggccagatagtggtcagtttacagacacga
gacagaataggaaccggcggctcggtggtggactgcagaggactgttagaaaatgaagga
acggtgtatgaagactccgggcctgggaggccgctcagctgcttcatggaggaaccagcc
ccttacacagatagcaccggtgctgctgctggaggagggaattgcaggttcgtggagtcc
ccaagtcaagatcaaagacttcaggcacagcggcttcgaaaccctgatgtgcgaggttca
ctacagacgccccagaaccgaccacacggccaccagtccccggaactgcccgaaggctac
gaacaaagaacaacagtccagggccaagtttactttttgcatacacagactggagttagc
acgtggcacgaccccaggataccaagtccctcggggaccattcctgggggagatgcagct
tttctatacgaattccttctacaaggccatacatctgagcccagagaccttaacagtgtg
aactgtgatgaacttggaccactgccgccaggctgggaagtcagaagtacagtttctggg
aggatatattttgtagatcataataaccgaacaacccagtttacagacccaaggttacac
cacatcatgaatcaccagtgccaactcaaggagcccagccagccgctgccactgcccagt
gagggctctctggaggacgaggagcttcctgcccagagatacgaaagagatctagtccag
aagctgaaagtcctcagacacgaactgtcgcttcagcagccccaagctggtcattgccgc
atcgaagtgtccagagaagaaatctttgaggagtcttaccgccagataatgaagatgcga
ccgaaagacttgaaaaaacggctgatggtgaaattccgtggggaagaaggtttggattac
ggtggtgtggccagggagtggctttacttgctgtgccatgaaatgctgaatccttattac
gggctcttccagtattctacggacaatatttacatgttgcaaataaatccggattcttca
atcaaccccgaccacttgtcttatttccactttgtggggcggatcatggggctggctgtg
ttccatggacactacatcaacgggggcttcacagtgcccttctacaagcagctgctgggg
aagcccatccagctctcagatctggaatctgtggacccagagctgcataagagcttggtg
tggatcctagagaacgacatcacgcctgtactggaccacaccttctgcgtggaacacaac
gccttcgggcggatcctgcagcatgaactgaaacccaatggcagaaatgtgccagtcaca
gaggagaataagaaagaatacgtccggttgtatgtaaactggaggtttatgagaggaatc
gaagcccagttcttagctctgcagaaggggttcaatgagctcatccctcaacatctgctg
aagccttttgaccagaaggaactggagctgatcataggcggcctggataaaatagacttg
aacgactggaagtcgaacacgcggctgaagcactgtgtggccgacagcaacatcgtgcgg
tggttctggcaagcggtggagacgttcgatgaagaaaggagggccaggctcctgcagttt
gtgactgggtccacgcgagtcccgctccaaggcttcaaggctttgcaaggttctacaggc
gcggcagggccccggctgttcaccatccacctgatagacgcgaacacagacaaccttccg
aaggcccatacctgctttaaccggatcgacattccaccatatgagtcctatgagaagctc
tacgagaagctgctgacagccgtggaggagacctgcgggtttgctgtggagtga

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (35)   
   RefSeq(nuc) (7)   
   GenBank (14)   
   EMBL (14)   
3D Structure (5)   
   PDB (5)   
Protein domain (3)   
   Pfam (3)   
All databases (81)   

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