KEGG   Homo sapiens (human): 57580
Entry
57580             CDS       T01001                                 
Symbol
PREX1, P-REX1
Name
(RefSeq) phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
  KO
K12365  phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Organism
hsa  Homo sapiens (human)
Pathway
hsa04062  Chemokine signaling pathway
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06224  CXCR signaling (cancer)
  Element
N00153  CCR/CXCR-GNB/G-PI3K-RAC signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    57580 (PREX1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    57580 (PREX1)
SSDB
Motif
Pfam: RhoGEF DEP PDZ_6 PDZ PH PH_10 ECT2_PH
Other DBs
NCBI-GeneID: 57580
NCBI-ProteinID: NP_065871
OMIM: 606905
HGNC: 32594
Ensembl: ENSG00000124126
UniProt: Q8TCU6
Structure
Position
20:complement(48624252..48888185)
AA seq 1659 aa
MEAPSGSEPGGDGAGDCAHPDPRAPGAAAPSSGPGPCAAARESERQLRLRLCVLNEILGT
ERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYC
LHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGG
RKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINET
KRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNLLVY
CKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWK
IHNTAKNKWFVCMAKTAEEKQKWLDAIIREREQRESLKLGMERDAYVMIAEKGEKLYHMM
MNKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGIIHHVS
DKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYTPVIKDRDYHLKTYK
SVLPGSKLVDWLLAQGDCQTREEAVALGVGLCNNGFMHHVLEKSEFRDESQYFRFHADEE
MEGTSSKNKQLRNDFKLVENILAKRLLILPQEEDYGFDIEEKNKAVVVKSVQRGSLAEVA
GLQVGRKIYSINEDLVFLRPFSEVESILNQSFCSRRPLRLLVATKAKEIIKIPDQPDTLC
FQIRGAAPPYVYAVGRGSEAMAAGLCAGQCILKVNGSNVMNDGAPEVLEHFQAFRSRREE
ALGLYQWIYHTHEDAQEARASQEASTEDPSGEQAQEEDQADSAFPLLSLGPRLSLCEDSP
MVTLTVDNVHLEHGVVYEYVSTAGVRCHVLEKIVEPRGCFGLTAKILEAFAANDSVFVEN
CRRLMALSSAIVTMPHFEFRNICDTKLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEPH
PLCGLDFCPTNCHINLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPMSYTQH
CITTMAAPSWKCLPAAEGDPQGQGLHDGSFGPASGTLGQEDRGLSFLLKQEDREIQDAYL
QLFTKLDVALKEMKQYVTQINRLLSTITEPTSGGSCDASLAEEASSLPLVSEESEMDRSD
HGGIKKVCFKVAEEDQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDEMGS
GDELPCDMRIPSDKQDKLHGCLEHLFNQVDSINALLKGPVMSRAFEETKHFPMNHSLQEF
KQKEECTIRGRSLIQISIQEDPWNLPNSIKTLVDNIQRYVEDGKNQLLLALLKCTDTELQ
LRRDAIFCQALVAAVCTFSKQLLAALGYRYNNNGEYEESSRDASRKWLEQVAATGVLLHC
QSLLSPATVKEERTMLEDIWVTLSELDNVTFSFKQLDENYVANTNVFYHIEGSRQALKVI
FYLDSYHFSKLPSRLEGGASLRLHTALFTKVLENVEGLPSPGSQAAEDLQQDINAQSLEK
VQQYYRKLRAFYLERSNLPTDASTTAVKIDQLIRPINALDELCRLMKSFVHPKPGAAGSV
GAGLIPISSELCYRLGACQMVMCGTGMQRSTLSVSLEQAAILARSHGLLPKCIMQATDIM
RKQGPRVEILAKNLRVKDQMPQGAPRLYRLCQPPVDGDL
NT seq 4980 nt   +upstreamnt  +downstreamnt
atggaggcgcccagcggcagcgagcccggcggcgacggggccggggactgcgcccacccg
gacccccgggcccctggcgccgcggcgcccagctccggccccggcccgtgcgcggccgcc
cgggagtccgagcgccagctgcgcctccgcctctgcgtcctcaacgagatcttgggcacc
gagagggactacgtgggcaccttgcgcttcttgcagtcggcattcctgcatcgcatccgg
cagaacgtggccgactcagtggagaagggcctcacggaggagaatgtcaaggtcctgttc
tcgaacatcgaagacatcctggaagttcataaggatttcttggccgccttggagtattgt
ttacacccggagccgcagtctcagcatgaacttgggaatgttttcttaaaattcaaggac
aagttctgcgtgtacgaggagtattgcagcaaccatgagaaagccctgaggctgctggtg
gagctgaacaagatccctaccgtgcgcgccttccttttgagctgcatgcttctgggaggc
cggaagaccacggacatccctttggaaggctacctgttgtctccgatccagaggatctgc
aagtacccgctcctccttaaggagctggccaagaggactcccggcaagcacccagaccac
cccgcggtccagagtgccctgcaggccatgaagaccgtttgctccaacatcaatgagacc
aagcggcagatggagaagctggaagccctggagcagctgcagtcccacatcgaaggctgg
gagggttccaacctcacagacatctgcactcagctcctcctgcaagggactttgttaaag
atctctgcgggcaacatccaggaaagggccttcttcctcttcgacaaccttctcgtctac
tgcaagcggaaatccagggtcaccgggagcaagaagtccaccaagaggaccaaatccatc
aacggctccctctacatcttcaggggtcgaatcaacactgaagtcatggaggtggagaat
gtggaagatgggacagcggattaccatagcaacggctataccgtcaccaacggctggaag
atccacaacacggccaagaataagtggtttgtctgcatggccaagacggcagaggagaag
cagaagtggctggatgccatcatccgcgagcgggagcagcgcgagagcctgaagctgggc
atggagcgtgatgcctacgtcatgattgcggagaagggggagaagctgtaccacatgatg
atgaacaagaaggtgaacctcatcaaggaccgccggagaaagctgagcactgtccccaag
tgctttcttggcaatgagttcgttgcctggctcctagaaattggtgaaatcagcaagacg
gaagaaggagtcaacttgggccaagccctgttggagaatggcatcatccaccatgtttcc
gacaagcaccagttcaagaatgagcaggtgatgtatcgcttccgctacgacgatggcacc
tacaaggcccgaagtgagctggaggacatcatgtccaagggtgtgaggctttactgccgt
cttcacagcctctacaccccggtgatcaaagaccgtgattaccacctgaagacctacaag
tcagtgcttcccgggagcaagctggtggactggctgctggctcagggagactgccagact
cgggaggaggcagtggcgctcggcgtgggtctgtgcaacaatggcttcatgcaccacgtg
ctggagaagagcgagttcagggatgagtcccagtacttccgctttcatgctgacgaggag
atggaggggaccagcagcaagaacaaacagcttcgcaacgacttcaagctggtggagaac
attctggccaagcgcctgctgatcctgccccaggaggaggactatggctttgacatcgag
gagaagaacaaggctgtggtggtgaagtccgtccagaggggctcgctggctgaggtggct
ggcctgcaggtggggaggaagatctactccatcaatgaggacctggtgttcctgcggccg
ttttcagaggtggagtccatcctcaaccagtccttctgctcccgccgccctctgcgcctc
ctggtggccacgaaggccaaagagatcatcaaaatccccgaccagccggacacactgtgc
ttccagattcgtggagctgccccaccgtacgtctatgctgtggggagaggctctgaggcc
atggctgcagggctctgtgctggtcagtgcattctgaaggtcaatggcagcaacgtgatg
aacgatggtgcccctgaggtcctggagcacttccaggcattccggagtcggcgcgaagag
gccctgggcctgtaccagtggatctaccacacccatgaggatgcccaggaagcacgagcc
agtcaggaggcctccactgaggaccccagtggcgagcaggcccaggaggaagaccaggct
gattcagccttcccactgctgtccctgggtccccggctgagcctgtgtgaggacagcccc
atggtcaccctgactgtggacaacgtgcacctggaacacggcgtggtgtatgagtatgtg
agcacggcaggcgtcaggtgccatgtgctggagaagatcgtggagccccgcggctgcttc
ggcctcaccgccaagatcctcgaggcctttgctgccaatgacagcgtcttcgtggagaac
tgcaggcggctcatggccctgagcagcgccatcgtgaccatgccccactttgagttccgc
aacatctgtgacaccaagctggagagcattggccagaggattgcctgctaccaggagttt
gcagcccaactgaagagcagggtcagcccacccttcaaacaagcccccctggagccccac
ccgctgtgtggcctggacttctgccccaccaattgccacatcaacctcatggaagtgtcc
taccccaagaccaccccctcagtgggcaggtccttcagcatccgctttggacgcaaaccc
tccctcatcggccttgacccggagcaaggccacctgaaccccatgtcgtacacccagcac
tgcatcaccaccatggctgctccctcctggaagtgcttgcctgctgcagagggtgatccc
caaggccagggtctccatgatggcagcttcgggccagccagtgggacccttggtcaggaa
gaccggggcctcagcttcctactcaagcaggaggaccgtgagatccaggatgcctacctg
cagctcttcaccaagctggatgtggccctgaaggagatgaagcaatatgtcacccagatc
aacaggctgctgtccaccatcacagagcccacctcgggtgggtcctgcgacgcatccttg
gctgaggaggcctcctccctgcccctggtcagtgaagagagcgagatggacaggagtgac
catgggggcatcaagaaggtgtgcttcaaggtggccgaggaggaccaggaggactcaggc
cacgacaccatgagttatcgcgactcctacagcgagtgtaacagcaatcgagactcggtc
ctgtcctacaccagcgtgagaagtaacagctcctacttgggcagcgacgagatggggtct
ggagatgagctgccctgtgacatgcggatcccatctgacaagcaggacaagcttcatggc
tgcctggagcacctctttaaccaggtggactccatcaatgctctcctcaaggggccagtc
atgagccgggctttcgaagagaccaagcatttccctatgaaccacagcttacaagagttt
aaacagaaagaagagtgtacaatccgtggccggagcctgatccagattagcatccaggag
gacccctggaacctccccaactccatcaagaccctggtggacaacattcagagatatgtg
gaagatgggaagaaccagctgctcctggccttgctgaagtgcacagacacggagctgcag
ctgcgcagagacgcgatcttctgccaggccctggtggccgccgtgtgcaccttctccaag
cagctgctggcggccctgggctaccgctacaacaacaatggcgagtacgaggagagcagc
cgcgacgccagccgcaagtggctggagcaggtggcggccacgggcgtcctgctgcactgc
cagtccctgctctcgccagccacagtgaaggaggaacggaccatgctggaggacatctgg
gtgacgctgtcagagctggacaatgtcaccttctcctttaagcagctggacgagaactat
gtggccaacaccaacgtcttctaccacattgagggcagccggcaggcgctgaaggtcatc
ttctacctcgacagctaccacttctccaagctgccctcccgcctggagggtggggccagc
ctgaggctgcacacagcgctgttcacgaaagtgctggagaacgtggaggggctgccttct
ccaggcagccaggccgcggaggatttgcagcaggacatcaacgcgcagtccctggagaaa
gttcagcagtattaccgcaaactcagggcattttacctggagcggtctaacctgcccacg
gatgccagcaccacggcggtaaagatagaccagctgatccgccccatcaatgccctggat
gagctctgccgcctcatgaagtcctttgtccacccaaagcctggtgctgctgggagtgtg
ggcgccggcctcatccccatctcctcggagctctgctaccgcctgggggcctgccagatg
gtcatgtgtggcacaggcatgcagaggagcaccctgagcgtgtccctggagcaggcggcc
atcttggcacggagccacgggttgctgcccaagtgcatcatgcaggccacggacatcatg
cggaagcagggcccaagggtggagattctggccaaaaacctgcgagtcaaggaccagatg
ccccagggtgctccgcgcctctaccgcctctgccagccgccggtggatggggacctctga

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (2)   
   KEGG PATHWAY (2)   
Network (3)   
   KEGG NETWORK (3)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (11)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (9)   
DNA sequence (23)   
   RefSeq(nuc) (9)   
   GenBank (7)   
   EMBL (7)   
3D Structure (12)   
   PDB (12)   
Protein domain (7)   
   Pfam (7)   
All databases (79)   

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