KEGG   Homo sapiens (human): 59272
Entry
59272             CDS       T01001                                 
Symbol
ACE2, ACEH
Name
(RefSeq) angiotensin converting enzyme 2
  KO
K09708  angiotensin-converting enzyme 2 [EC:3.4.17.23]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04614  Renin-angiotensin system
hsa04974  Protein digestion and absorption
hsa05171  Coronavirus disease - COVID-19
Network
nt06171  SARS coronavirus 2 (SARS-CoV-2)
  Element
N01307  SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03262 Virion - Coronavirus
    59272 (ACE2)
 09150 Organismal Systems
  09152 Endocrine system
   04614 Renin-angiotensin system
    59272 (ACE2)
  09154 Digestive system
   04974 Protein digestion and absorption
    59272 (ACE2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    59272 (ACE2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    59272 (ACE2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    59272 (ACE2)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.17  Metallocarboxypeptidases
    3.4.17.23  angiotensin-converting enzyme 2
     59272 (ACE2)
Peptidases and inhibitors [BR:hsa01002]
 Metallo peptidases
  Family M2
   59272 (ACE2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   59272 (ACE2)
SSDB
Motif
Pfam: Peptidase_M2 Collectrin KIAA1549 Glycophorin_A TBCC_N
Other DBs
NCBI-GeneID: 59272
NCBI-ProteinID: NP_068576
OMIM: 300335
HGNC: 13557
Ensembl: ENSG00000130234
UniProt: Q9BYF1
Structure
Position
X:complement(15518197..15607211)
AA seq 805 aa
MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQ
NMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTIL
NTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLY
EEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHL
HAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQ
AWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILM
CTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKS
IGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEM
KREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLH
KCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNK
NSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAMRQYFLKVKN
QMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRINDAFRLNDN
SLEFLGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKKNKARSGENP
YASIDISKGENNPGFQNTDDVQTSF
NT seq 2418 nt   +upstreamnt  +downstreamnt
atgtcaagctcttcctggctccttctcagccttgttgctgtaactgctgctcagtccacc
attgaggaacaggccaagacatttttggacaagtttaaccacgaagccgaagacctgttc
tatcaaagttcacttgcttcttggaattataacaccaatattactgaagagaatgtccaa
aacatgaataatgctggggacaaatggtctgcctttttaaaggaacagtccacacttgcc
caaatgtatccactacaagaaattcagaatctcacagtcaagcttcagctgcaggctctt
cagcaaaatgggtcttcagtgctctcagaagacaagagcaaacggttgaacacaattcta
aatacaatgagcaccatctacagtactggaaaagtttgtaacccagataatccacaagaa
tgcttattacttgaaccaggtttgaatgaaataatggcaaacagtttagactacaatgag
aggctctgggcttgggaaagctggagatctgaggtcggcaagcagctgaggccattatat
gaagagtatgtggtcttgaaaaatgagatggcaagagcaaatcattatgaggactatggg
gattattggagaggagactatgaagtaaatggggtagatggctatgactacagccgcggc
cagttgattgaagatgtggaacatacctttgaagagattaaaccattatatgaacatctt
catgcctatgtgagggcaaagttgatgaatgcctatccttcctatatcagtccaattgga
tgcctccctgctcatttgcttggtgatatgtggggtagattttggacaaatctgtactct
ttgacagttccctttggacagaaaccaaacatagatgttactgatgcaatggtggaccag
gcctgggatgcacagagaatattcaaggaggccgagaagttctttgtatctgttggtctt
cctaatatgactcaaggattctgggaaaattccatgctaacggacccaggaaatgttcag
aaagcagtctgccatcccacagcttgggacctggggaagggcgacttcaggatccttatg
tgcacaaaggtgacaatggacgacttcctgacagctcatcatgagatggggcatatccag
tatgatatggcatatgctgcacaaccttttctgctaagaaatggagctaatgaaggattc
catgaagctgttggggaaatcatgtcactttctgcagccacacctaagcatttaaaatcc
attggtcttctgtcacccgattttcaagaagacaatgaaacagaaataaacttcctgctc
aaacaagcactcacgattgttgggactctgccatttacttacatgttagagaagtggagg
tggatggtctttaaaggggaaattcccaaagaccagtggatgaaaaagtggtgggagatg
aagcgagagatagttggggtggtggaacctgtgccccatgatgaaacatactgtgacccc
gcatctctgttccatgtttctaatgattactcattcattcgatattacacaaggaccctt
taccaattccagtttcaagaagcactttgtcaagcagctaaacatgaaggccctctgcac
aaatgtgacatctcaaactctacagaagctggacagaaactgttcaatatgctgaggctt
ggaaaatcagaaccctggaccctagcattggaaaatgttgtaggagcaaagaacatgaat
gtaaggccactgctcaactactttgagcccttatttacctggctgaaagaccagaacaag
aattcttttgtgggatggagtaccgactggagtccatatgcagaccaaagcatcaaagtg
aggataagcctaaaatcagctcttggagataaagcatatgaatggaacgacaatgaaatg
tacctgttccgatcatctgttgcatatgctatgaggcagtactttttaaaagtaaaaaat
cagatgattctttttggggaggaggatgtgcgagtggctaatttgaaaccaagaatctcc
tttaatttctttgtcactgcacctaaaaatgtgtctgatatcattcctagaactgaagtt
gaaaaggccatcaggatgtcccggagccgtatcaatgatgctttccgtctgaatgacaac
agcctagagtttctggggatacagccaacacttggacctcctaaccagccccctgtttcc
atatggctgattgtttttggagttgtgatgggagtgatagtggttggcattgtcatcctg
atcttcactgggatcagagatcggaagaagaaaaataaagcaagaagtggagaaaatcct
tatgcctccatcgatattagcaaaggagaaaataatccaggattccaaaacactgatgat
gttcagacctccttttag

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (3)   
   KEGG PATHWAY (3)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (25)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   NAGAHAMA-H (12)   
   OC (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (48)   
   RefSeq(nuc) (6)   
   GenBank (21)   
   EMBL (21)   
3D Structure (224)   
   PDB (224)   
Protein domain (5)   
   Pfam (5)   
All databases (322)   

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