KEGG   Homo sapiens (human): 64087
Entry
64087             CDS       T01001                                 
Symbol
MCCC2, MCCB, MCCCbeta
Name
(RefSeq) methylcrotonyl-CoA carboxylase subunit 2
  KO
K01969  3-methylcrotonyl-CoA carboxylase beta subunit [EC:6.4.1.4]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00280  Valine, leucine and isoleucine degradation
hsa01100  Metabolic pathways
Module
hsa_M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA
Network
nt06024  Valine, leucine and isoleucine degradation
  Element
N00851  Leucine degradation
Disease
H00181  3-Methylcrotonylglycinuria
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    64087 (MCCC2)
Enzymes [BR:hsa01000]
 6. Ligases
  6.4  Forming carbon-carbon bonds
   6.4.1  Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
    6.4.1.4  methylcrotonoyl-CoA carboxylase
     64087 (MCCC2)
SSDB
Motif
Pfam: Carboxyl_trans MdcE
Other DBs
NCBI-GeneID: 64087
NCBI-ProteinID: NP_071415
OMIM: 609014
HGNC: 6937
Ensembl: ENSG00000131844
UniProt: Q9HCC0 A0A140VK29
Position
5:71587340..71658706
AA seq 563 aa
MWAVLRLALRPCARASPAGPRAYHGDSVASLGTQPDLGSALYQENYKQMKALVNQLHERV
EHIKLGGGEKARALHISRGKLLPRERIDNLIDPGSPFLELSQFAGYQLYDNEEVPGGGII
TGIGRVSGVECMIIANDATVKGGAYYPVTVKKQLRAQEIAMQNRLPCIYLVDSGGAYLPR
QADVFPDRDHFGRTFYNQAIMSSKNIAQIAVVMGSCTAGGAYVPAMADENIIVRKQGTIF
LAGPPLVKAATGEEVSAEDLGGADLHCRKSGVSDHWALDDHHALHLTRKVVRNLNYQKKL
DVTIEPSEEPLFPADELYGIVGANLKRSFDVREVIARIVDGSRFTEFKAFYGDTLVTGFA
RIFGYPVGIVGNNGVLFSESAKKGTHFVQLCCQRNIPLLFLQNITGFMVGREYEAEGIAK
DGAKMVAAVACAQVPKITLIIGGSYGAGNYGMCGRAYSPRFLYIWPNARISVMGGEQAAN
VLATITKDQRAREGKQFSSADEAALKEPIIKKFEEEGNPYYSSARVWDDGIIDPADTRLV
LGLSFSAALNAPIEKTDFGIFRM
NT seq 1692 nt   +upstreamnt  +downstreamnt
atgtgggccgtcctgaggttagccctgcggccgtgtgcccgcgcctctcccgccgggccg
cgcgcctatcacggggactcggtggcctcgctgggcacccagccggacttgggctctgcc
ctctaccaggagaactacaagcagatgaaagcactagtaaatcagctccatgaacgagtg
gagcatataaaactaggaggtggtgagaaagcccgagcacttcacatatcaagaggaaaa
ctattgcccagagaaagaattgacaatctcatagacccagggtctccatttctggaatta
tcccagtttgcaggttaccagttatatgacaatgaggaggtgccaggaggtggcattatt
acaggcattggaagagtatcaggagtagaatgcatgattattgccaatgatgccaccgtc
aaaggaggtgcctactacccagtgactgtgaaaaaacaattacgggcccaagaaattgcc
atgcaaaacaggctcccctgcatctacttagttgattcgggaggagcatacttacctcga
caagcagatgtgtttccagatcgagaccactttggccgtacattctataatcaggcaatt
atgtcttctaaaaatattgcacagatcgcagtggtcatgggctcctgcaccgcaggagga
gcctatgtgcctgccatggctgatgaaaacatcattgtacgcaagcagggtaccattttc
ttggcaggaccccccttggttaaagcggcaactggggaagaagtatctgctgaggatctt
ggaggtgctgatcttcattgcagaaagtctggagtaagtgaccactgggctttggatgat
catcatgcccttcacttaactaggaaggttgtgaggaatctaaattatcagaagaaattg
gatgtcaccattgaaccttctgaagagcctttatttcctgctgatgaattgtatggaata
gttggtgctaaccttaagaggagctttgatgtccgagaggtcattgctagaatcgtggat
ggaagcagattcactgagttcaaagccttttatggagacacattagttacaggatttgct
cgaatatttgggtacccagtaggtatcgttggaaacaacggagttctcttttctgaatct
gcaaaaaagggtactcactttgtccagttatgctgccaaagaaatattcctctgctgttc
cttcaaaacattactggatttatggttggtagagagtatgaagctgaaggaattgccaag
gatggtgccaagatggtggccgctgtggcctgtgcccaagtgcctaagataaccctcatc
attgggggctcctatggagccggaaactatgggatgtgtggcagagcatatagcccaaga
tttctctacatttggccaaatgctcgtatctcagtgatgggaggagagcaggcagccaat
gtgttggccacgataacaaaggaccaaagagcccgggaaggaaagcagttctccagtgct
gatgaagcggctttaaaagagcccatcattaagaagtttgaagaggaaggaaacccttac
tattccagcgcaagggtatgggatgatgggatcattgatccagcagacaccagactggtc
ttgggtctcagttttagtgcagccctcaacgcaccaatagagaagactgacttcggtatc
ttcaggatgtaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (2)   
   KEGG MODULE (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (16)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (13)   
DNA sequence (41)   
   RefSeq(nuc) (13)   
   GenBank (14)   
   EMBL (14)   
Protein domain (2)   
   Pfam (2)   
All databases (96)   

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