KEGG   Homo sapiens (human): 64283
Entry
64283             CDS       T01001                                 
Symbol
ARHGEF28, RGNEF, RIP2, p190RHOGEF
Name
(RefSeq) Rho guanine nucleotide exchange factor 28
  KO
K21072  A-kinase anchor protein 28
Organism
hsa  Homo sapiens (human)
Pathway
hsa05135  Yersinia infection
Network
nt06181  Salmonella
nt06182  Shigella
nt06183  Yersinia
  Element
N01072  ITGA/B-RhoGEF-RhoA signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    64283 (ARHGEF28)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    64283 (ARHGEF28)
Membrane trafficking [BR:hsa04131]
 Others
  Rho GTPase associated proteins
   Rho guanine nucleotide exchange factors (GEFs)
    64283 (ARHGEF28)
SSDB
Motif
Pfam: PH_16 RhoGEF C1_1 PH PHD C1_2 Prok-RING_1 PH_13
Other DBs
NCBI-GeneID: 64283
NCBI-ProteinID: NP_001171164
OMIM: 612790
HGNC: 30322
Ensembl: ENSG00000214944
UniProt: Q8N1W1
Structure
Position
5:73626196..73941990
AA seq 1705 aa
MELSCSEAPLYGQMMIYAKFDKNVYLPEDAEFYFTYDGSHQRHVMIAERIEDNVLQSSVP
GHGLQETVTVSVCLCSEGYSPVTMGSGSVTYVDNMACRLARLLVTQANRLTACSHQTLLT
PFALTAGALPALDEELVLALTHLELPLEWTVLGSSSLEVSSHRESLLHLAMRWGLAKLSQ
FFLCLPGGVQALALPNEEGATPLDLALREGHSKLVEDVTNFQGRWSPSFSRVQLSEEASL
HYIHSSETLTLTLNHTAEHLLEADIKLFRKYFWDRAFLVKAFEPEARPEERTAMPSSGAE
TEEEIKNSVSSRSAAEKEDIKRVKSLVVQHNEHEDQHSLDLDRSFDILKKSKPPSTLLAA
GRLSDMLNGGDEVYANCMVIDQVGDLDISYINIEGITATTSPESRGCTLWPQSSKHTLPT
ETSPSVYPLSENVEGTAHTEAQQSFMSPSSSCASNLNLSFGWHGFEKEQSHLKKRSSSLD
ALDADSEGEGHSEPSHICYTPGSQSSSRTGIPSGDELDSFETNTEPDFNISRAESLPLSS
NLQSKESLLSGVRSRSYSCSSPKISLGKTRLVRELTVCSSSEEQRAYSLSEPPRENRIQE
EEWDKYIIPAKSESEKYKVSRTFSFLMNRMTSPRNKSKTKSKDAKDKEKLNRHQFAPGTF
SGVLQCLVCDKTLLGKESLQCSNCNANVHKGCKDAAPACTKKFQEKYNKNKPQTILGNSS
FRDIPQPGLSLHPSSSVPVGLPTGRRETVGQVHPLSRSVPGTTLESFRRSATSLESESDH
NSCRSRSHSDELLQSMGSSPSTESFIMEDVVDSSLWSDLSSDAQEFEAESWSLVVDPSFC
NRQEKDVIKRQDVIFELMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDEL
LEIHRHFFYSMKERRQESCAGSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKE
AVNLFKELQQNKKFQNFIKLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKER
TEEHKDLRKALCLIKDMIATVDLKVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQAL
MSEERTLLYDGLVYWKTATGRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPSVISLQK
LIAREVANEERGMFLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVESCPEEKGGRTSE
SDEDKRKAEARVAKIQQCQEILTNQDQQICAYLEEKLHIYAELGELSGFEDVHLEPHLLI
KPDPGEPPQAASLLAAALKEAESLQVAVKASQMGAVSQSCEDSCGDSVLADTLSSHDVPG
SPTASLVTGGREGRGCSDVDPGIQGVVTDLAVSDAGEKVECRNFPGSSQSEIIQAIQNLT
RLLYSLQAALTIQDSHIEIHRLVLQQQEGLSLGHSILRGGPLQDQKSRDADRQHEELANV
HQLQHQLQQEQRRWLRRCEQQQRAQATRESWLQERERECQSQEELLLRSRGELDLQLQEY
QHSLERLREGQRLVEREQARMRAQQSLLGHWKHGRQRSLPAVLLPGGPEVMELNRSESLC
HENSFFINEALVQMSFNTFNKLNPSVIHQDATYPTTQSHSDLVRTSEHQVDLKVDPSQPS
NVSHKLWTAAGSGHQILPFHESSKDSCKNDLDTSHTESPTPHDSNSHRPQLQAFITEAKL
NLPTRTMTRQDGETGDGAKENIVYL
NT seq 5118 nt   +upstreamnt  +downstreamnt
atggagttgagctgcagcgaagcacctctttacgggcagatgatgatctatgcgaagttt
gacaaaaatgtgtatcttcctgaagatgctgagttttactttacttatgacggatctcat
cagcgacatgtcatgattgcagagcgcatcgaggataacgttctccagtccagcgtccca
ggccatgggcttcaggagacggtgacggtatctgtgtgcctctgctcggaaggttactct
ccggtgaccatgggctctggctcagtgacctacgtggacaacatggcttgcaggctggct
cgtctgctggtgacgcaggccaatcgcctcacagcctgcagccaccagaccctgctgacc
ccatttgccttgacggcaggagcactgcctgccttggatgaggagctcgtgctggctctg
acccatctggaattgcctctagagtggactgtgttgggaagttcttcacttgaagtatct
tctcacagagaatctcttctacacctggctatgagatggggcctggctaaactttcccag
ttcttcttgtgtctcccggggggagtccaggccttggctttacccaacgaagagggtgcc
acaccattagacttagctttacgtgaaggacactccaagctggtggaagacgtcacaaat
tttcagggcagatggtccccaagcttctcccgagtgcagctcagtgaagaagcctccttg
cattacattcactcatcggaaacgctgaccctgaccctgaaccacacagccgagcatttg
ttggaggcagatattaaactcttccggaaatacttttgggatagagcctttcttgtcaag
gcctttgagccagaagccaggccagaggaaagaacagctatgccctccagcggtgcagaa
actgaagaagagattaagaattcagtgtccagcagatcagcagctgaaaaggaagatata
aagcgtgtcaaaagcctggtggttcaacacaatgaacatgaagaccagcacagcctagat
ttggatcgctccttcgatatcctaaaaaaatccaagccgccctcgacattgcttgctgca
ggccggctttcagacatgctgaatggaggtgatgaagtctacgctaactgtatggtgatt
gatcaggttggtgatttggatatcagctatattaatatagagggaatcactgccactacc
agccctgaatccagaggttgcactctgtggcctcagagcagcaaacacacccttcctaca
gaaaccagtcccagtgtgtacccacttagtgaaaatgtcgaagggacagcacacactgaa
gcccagcagtccttcatgtcaccatcaagttcgtgtgcttccaacttgaatctttctttt
ggttggcatggatttgaaaaggaacaaagtcatctaaagaaaagaagttctagccttgat
gccttggacgccgacagtgaaggggaagggcattctgagccatcccacatctgttacact
ccagggtctcagagctcctcaagaactgggattcctagtggggatgaattggactctttt
gagactaacactgaaccggattttaatatctccagggctgaatcccttcctctatcaagt
aatctacagtcgaaggaatcactgctttctggagttcgctcacgttcttattcttgctca
tcacccaaaatttctttaggaaaaactcgtttggtgcgtgaattaacagtatgcagttca
agtgaagagcaaagagcttacagcttatcggagccaccaagagaaaacagaattcaggaa
gaagaatgggataaatacatcatacctgccaaatcagagtctgaaaaatataaagtgagt
cgaactttcagtttcctcatgaataggatgactagccctcggaataaatcaaagacaaaa
agcaaggatgccaaagataaagagaagctgaatcgacatcagtttgccccaggaacattc
tctggggttctgcagtgtttggtttgtgataaaacactcctggggaaagagtcactgcag
tgttctaactgtaatgcaaatgtgcacaaaggttgtaaagatgctgcgcctgcatgcacc
aagaaattccaagagaaatataacaagaacaaaccacagaccatccttggaaattcttca
tttagagacatcccacagcctggtctctccttgcacccttcttcctccgtgcctgttgga
ttgccgactggaaggagggagactgtgggacaggtccatccattgtccagaagtgttcca
ggcaccaccttggaaagcttcaggaggtcagccacatccttggagtctgagagtgaccat
aacagctgcagaagcaggtctcattctgatgagctgctacagtccatgggctcttctccc
tctacagagtctttcataatggaagatgttgtggattcttctctgtggagtgacctcagc
agtgatgcccaggagtttgaagcagaatcttggagtcttgtggtggatccctcattttgt
aataggcaggagaaggatgtcatcaaaagacaggatgtcatttttgagctaatgcaaaca
gagatgcatcacatccagaccctgttcatcatgtctgagatcttcaggaaaggcatgaaa
gaggagctgcagctggaccacagcaccgtggataaaattttcccctgtttagatgagttg
cttgaaatccacaggcatttcttctacagtatgaaggaacgaaggcaggaatcctgtgct
ggcagcgacaggaattttgtgatcgaccgaattggagatattttggtacaacagttttca
gaagaaaatgcaagtaaaatgaagaaaatatatggagaattctgttgccatcataaagaa
gctgttaacctctttaaagaactccagcagaataaaaagtttcagaattttattaagctc
cgaaatagtaatcttttggctcgacgccgaggaattccagaatgcattctgttggtcact
cagcgtattacaaaataccctgtcttggtggaaaggatattgcagtacacaaaggaaaga
actgaggaacataaagacttacgcaaagcgctttgcttaattaaagacatgattgcaaca
gtggatttaaaagtcaatgaatatgagaaaaaccaaaaatggcttgagatcctaaataag
attgaaaacaaaacatacacgaagctcaaaaatggacatgtgtttaggaagcaggcactg
atgagtgaagaaaggactctgttatatgatggccttgtttactggaaaactgctacaggt
cgtttcaaagatatcctagctctacttctaactgatgtgctgctctttttacaagaaaaa
gaccagaaatacatctttgcagccgttgatcagaagccatcagttatttcccttcaaaag
cttattgctagagaagttgctaatgaggagagaggaatgtttctgatcagtgcttcatct
gctggtcctgagatgtatgaaattcacaccaattccaaggaggaacgcaataactggatg
agacggatccagcaggctgtagaaagttgtcctgaagaaaaagggggaaggacaagtgaa
tctgatgaagacaagaggaaagctgaagccagagtggccaaaattcagcaatgtcaagaa
atactcactaaccaagaccaacaaatttgtgcgtatttggaggagaagctgcatatctat
gctgaacttggagaactgagcggatttgaggacgtccatctagagccccacctccttatt
aaacctgacccaggcgagcctccccaggcagcctcattactggcagcagcactgaaagaa
gctgagagcctacaagttgcagtgaaggcctcacagatgggcgccgtgagtcaatcatgt
gaggacagttgtggagactctgtcttggcggacacactcagttctcatgatgtaccagga
tcaccgactgcctcattagtcacaggagggagagaaggaagaggctgttcggatgtggat
cccgggatccagggtgtggtaaccgacttggccgtctctgatgcaggggagaaggtggaa
tgtagaaattttccaggttcttcacaatcagagattatacaagccatacagaatttaacc
cgtctcttatacagccttcaggccgccttgaccattcaggacagccacattgagatccac
aggctggttctccagcagcaggagggcctgtctctcggccactctatcctccgaggcggc
cccttgcaggaccagaagtctcgcgacgcggacaggcagcatgaggagctggccaatgtg
caccagcttcagcaccagctccagcaggagcagcggcgctggctgcgcaggtgtgagcag
cagcagcgggcgcaggcgaccagggagagctggctgcaggagcgggagcgggagtgccag
tcgcaggaggagctgctgctgcggagccggggcgagctggacctccagctccaggagtac
cagcacagcctggagcggctgagggagggccagcgcctggtggagagggagcaggcgagg
atgcgggcccagcagagcctgctgggccactggaagcacggccggcagaggagcctgccc
gcggtgctccttccgggtggccccgaggtaatggaacttaatcgatctgagagtttatgt
catgaaaactcattcttcatcaatgaagctttagtacaaatgtcatttaacactttcaac
aaactgaatccatcagttatccatcaggatgccacttaccctacaactcaatctcattct
gacttggtgaggactagtgaacatcaagtagacctcaaggtggacccttctcagccttcg
aatgtcagtcacaaactgtggacagccgctggttccggccatcagatacttcctttccat
gaaagcagcaaggattcttgtaaaaatgatttggacacctcccacactgagtccccaacc
ccccatgactcaaattcacaccgccctcaactgcaggcgtttataacagaagcaaagcta
aatctaccgacaaggacaatgaccagacaagatggggaaactggagatggagccaaagaa
aatattgtttacctctaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (4)   
   KEGG NETWORK (4)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (44)   
   KEGG ORTHOLOGY (1)   
   RefGene (37)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (30)   
   RefSeq(nuc) (6)   
   GenBank (12)   
   EMBL (12)   
3D Structure (2)   
   PDB (2)   
Protein domain (8)   
   Pfam (8)   
All databases (100)   

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