KEGG   Homo sapiens (human): 6499
Entry
6499              CDS       T01001                                 
Symbol
SKIC2, 170A, DDX13, HLP, SKI2, SKI2W, SKIV2, SKIV2L, SKIV2L1, THES2
Name
(RefSeq) SKI2 subunit of superkiller complex
  KO
K12599  antiviral helicase SKI2 [EC:5.6.2.6]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03018  RNA degradation
Disease
H01805  Tricho-hepato-enteric syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03018 RNA degradation
    6499 (SKIC2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    6499 (SKIC2)
Enzymes [BR:hsa01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.6  RNA 3'-5' helicase
     6499 (SKIC2)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Transport factors
    eIF4F and regulatory proteins
     6499 (SKIC2)
  mRNA degradation factors
   3'-5' decay
    Ski complex
     6499 (SKIC2)
SSDB
Motif
Pfam: DSHCT Ski2_N MTR4_beta-barrel DEAD MTR4-like_stalk Helicase_C ResIII DUF3516
Other DBs
NCBI-GeneID: 6499
NCBI-ProteinID: NP_008860
OMIM: 600478
HGNC: 10898
Ensembl: ENSG00000204351
UniProt: Q15477 A0A1U9X8J1
Structure
Position
6:31959175..31969751
AA seq 1246 aa
MMETERLVLPPPDPLDLPLRAVELGCTGHWELLNLPGAPESSLPHGLPPCAPDLQQEAEQ
LFLSSPAWLPLHGVEHSARKWQRKTDPWSLLAVLGAPVPSDLQAQRHPTTGQILGYKEVL
LENTNLSATTSLSLRRPPGPASQSLWGNPTQYPFWPGGMDEPTITDLNTREEAEEEIDFE
KDLLTIPPGFKKGMDFAPKDCPTPAPGLLSLSCMLEPLDLGGGDEDENEAVGQPGGPRGD
TVSASPCSAPLARASSLEDLVLKEASTAVSTPEAPEPPSQEQWAIPVDATSPVGDFYRLI
PQPAFQWAFEPDVFQKQAILHLERHDSVFVAAHTSAGKTVVAEYAIALAQKHMTRTIYTS
PIKALSNQKFRDFRNTFGDVGLLTGDVQLHPEASCLIMTTEILRSMLYSGSDVIRDLEWV
IFDEVHYINDVERGVVWEEVLIMLPDHVSIILLSATVPNALEFADWIGRLKRRQIYVIST
VTRPVPLEHYLFTGNSSKTQGELFLLLDSRGAFHTKGYYAAVEAKKERMSKHAQTFGAKQ
PTHQGGPAQDRGVYLSLLASLRTRAQLPVVVFTFSRGRCDEQASGLTSLDLTTSSEKSEI
HLFLQRCLARLRGSDRQLPQVLHMSELLNRGLGVHHSGILPILKEIVEMLFSRGLVKVLF
ATETFAMGVNMPARTVVFDSMRKHDGSTFRDLLPGEYVQMAGRAGRRGLDPTGTVILLCK
GRVPEMADLHRMMMGKPSQLQSQFRLTYTMILNLLRVDALRVEDMMKRSFSEFPSRKDSK
AHEQALAELTKRLGALEEPDMTGQLVDLPEYYSWGEELTETQHMIQRRIMESVNGLKSLS
AGRVVVVKNQEHHNALGVILQVSSNSTSRVFTTLVLCDKPLSQDPQDRGPATAEVPYPDD
LVGFKLFLPEGPCDHTVVKLQPGDMAAITTKVLRVNGEKILEDFSKRQQPKFKKDPPLAA
VTTAVQELLRLAQAHPAGPPTLDPVNDLQLKDMSVVEGGLRARKLEELIQGAQCVHSPRF
PAQYLKLRERMQIQKEMERLRFLLSDQSLLLLPEYHQRVEVLRTLGYVDEAGTVKLAGRV
ACAMSSHELLLTELMFDNALSTLRPEEIAALLSGLVCQSPGDAGDQLPNTLKQGIERVRA
VAKRIGEVQVACGLNQTVEEFVGELNFGLVEVVYEWARGMPFSELAGLSGTPEGLVVRCI
QRLAEMCRSLRGAARLVGEPVLGAKMETAATLLRRDIVFAASLYTQ
NT seq 3741 nt   +upstreamnt  +downstreamnt
atgatggagacagagcgacttgtgctaccccctccagatcccctggacctaccccttcgg
gccgtggagctcggatgcacggggcactgggagctgctgaacttgcctggagctccagag
agtagccttccccatggcctccctccttgtgccccagatctgcagcaagaagcagaacag
ttgtttctgtcatccccagcctggctgcctctgcatggtgtggagcactcagcccgaaaa
tggcagaggaagacggatccctggtctcttttggctgtcctgggagccccagtcccatcc
gacctacaggcccaaagacacccaaccacaggccagatactgggttacaaagaggtcttg
ctggagaacacaaatctctcggctacaacctccttgtctcttcgccggcctccagggcca
gcctcccagtccttatggggaaatccaactcagtatcccttctggccaggggggatggat
gaacccaccataacagatctgaacacacgggaggaggctgaggaggagatagactttgag
aaagatcttcttactattccacctggtttcaagaaaggcatggactttgcaccaaaagat
tgtccaactccagctcctggactactaagccttagctgtatgttggagcctctggatttg
ggtgggggtgacgaggatgagaatgaggcagtgggacagccaggaggtcccagaggggac
actgtttcagcctctccctgcagtgctcccctggcccgagcaagcagcttggaagaccta
gtgttgaaggaagcgtccacagctgtatccaccccagaggccccagagcctccatctcag
gagcagtgggccatccctgtggacgccacctcccctgttggtgatttctatcgcctcatt
ccccagccagccttccagtgggcatttgagccagatgtgtttcagaaacaggccatcctg
cacttggaacggcatgactctgtctttgtcgcagctcacacatctgcaggaaaaacagtt
gtggctgaatatgccattgccctggcccagaaacacatgacacgcaccatctacacttcg
cccatcaaggccctgagcaaccagaagttccgggacttccgaaacacattcggggatgtg
gggctgctcaccggggatgtacagctgcatccggaggcctcctgcctcatcatgaccaca
gagatccttcgctccatgctgtacagtggctcagatgttattcgggacctggagtgggtc
atctttgatgaggttcactatatcaacgatgtcgagcgtggggtcgtgtgggaggaggtg
cttatcatgctacctgaccacgtttctatcatccttctgagtgccaccgtccccaacgcc
cttgagtttgctgactggattgggcggctgaagcgtcgtcagatctatgtgattagcact
gtaacccgccccgtgcccctggagcactatcttttcacagggaacagctccaagacccag
ggggagctctttttgttgctggactcccgaggagccttccatacaaaagggtactatgca
gctgtggaggccaagaaggagagaatgagcaaacacgcccagacctttggggccaagcag
cccacacatcaggggggccctgcacaggaccgcggagtgtacctgtccctcctggcctcc
ctccgcacacgtgcccagttgcccgtggtggtgttcaccttctcccggggccgctgtgat
gagcaggcctcaggcctcacctcccttgacctcaccaccagttcggagaagagcgagatc
cacctcttcctgcagcgctgccttgctcgcctccgtggctctgaccgccagctgccccag
gtcctgcacatgtcagagctcctgaatcgcggcctgggtgtgcaccatagcggcatcctg
cccatcctcaaggagatcgtggagatgctcttcagccgtggcctggtcaaggtcttgttt
gccacagagacctttgccatgggagtaaacatgcctgctcgtacagtagtgtttgactcc
atgcgcaaacacgatggctccaccttccgggacctgctccctggggagtatgtgcagatg
gcaggccgggcagggcggaggggcctggaccccacaggcaccgttatcctgctctgcaag
ggccgagtgcccgagatggcagacctgcaccgcatgatgatggggaagccgtcccagctg
cagtcccagttccgcctcacgtacactatgatcctcaacttgctgcgagtggatgccctc
agggtggaggacatgatgaagaggagcttctctgagtttccctcccgcaaagacagcaag
gcccatgaacaggccctggctgaactgaccaagaggctgggagctttggaggagcctgac
atgactggccaactggtcgacctgcctgaatattacagctggggggaggaactgacagag
acccagcacatgatccagcgacgcatcatggagtctgtgaacgggctgaagtctctctca
gcaggaagggtggtggttgtgaagaatcaggagcatcacaacgcattgggagtgatccta
caggtctcctcgaactccaccagcagagtattcacaaccctggtcttgtgtgataagccc
ttgtcccaggacccacaggacagggggccagccactgcagaggtgccctatccagatgac
ctcgtgggattcaagctgttcctgcctgaagggccttgtgaccacaccgtggtcaagctc
cagccaggagatatggctgccatcaccaccaaggtgctccgggtgaatggggagaagatc
ttggaggacttcagcaagaggcagcagccaaaattcaagaaggatcctccccttgcagcc
gtgaccactgctgtccaggaactgctgcgtctggctcaggcccacccagccggacctccc
accctcgaccctgtcaatgacctgcagctcaaagatatgtcagttgtagagggtgggctc
cgggcccggaagctggaggagctgatccagggggctcagtgtgtacacagcccccgtttt
cctgcccagtacctgaagctgcgggagcgaatgcagatacagaaggagatggagcggctg
cgcttcctactgtcggatcagtcattgctgctgcttcctgagtaccatcagcgagtagag
gtgctccgaaccctgggttatgtggacgaggcgggcactgtgaagctggcagggcgggtg
gcttgtgccatgagcagccatgagttgctcctcactgagctcatgtttgacaatgcactg
agcaccctgcggcctgaggagattgctgccttgctctctggcctggtctgccagagccct
ggggacgctggggatcagctcccaaacaccctcaagcagggaatagaacgtgtccgggct
gtggccaagcggattggtgaggtccaggtggcttgtggcctgaaccagacggtggaggaa
tttgtgggggagctgaattttgggctggttgaggttgtatatgagtgggcccggggcatg
cccttctccgagttggcagggctctcagggacccctgagggcctggtggtccgctgcatt
cagcgcctggctgagatgtgtcgctcactgcggggggcagcccgcctggtaggagagcct
gtgctgggtgccaagatggagacagcggctaccttgctacggcgggacatcgtatttgcg
gccagcctctacacccagtga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (25)   
   KEGG ORTHOLOGY (1)   
   RefGene (17)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (25)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (22)   
DNA sequence (46)   
   RefSeq(nuc) (22)   
   GenBank (12)   
   EMBL (12)   
3D Structure (5)   
   PDB (5)   
Protein domain (8)   
   Pfam (8)   
All databases (118)   

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