KEGG   Homo sapiens (human): 6708
Entry
6708              CDS       T01001                                 
Symbol
SPTA1, EL2, HPP, HS3, SPH3, SPTA
Name
(RefSeq) spectrin alpha, erythrocytic 1
  KO
K27408  spectrin alpha, erythrocytic
Organism
hsa  Homo sapiens (human)
Disease
H00230  Hereditary spherocytosis
H00231  Hereditary elliptocytosis
H01125  Hereditary pyropoikilocytosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    6708 (SPTA1)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Cross-linking proteins
     6708 (SPTA1)
  Intermediate filaments
   Intermediate filament-binding proteins
    6708 (SPTA1)
SSDB
Motif
Pfam: Spectrin EFhand_Ca_insen SH3_1 SH3_9 EF-hand_7 EF-hand_6 SH3_2 EF-hand_1 SH3_10 DUF4633
Other DBs
NCBI-GeneID: 6708
NCBI-ProteinID: NP_003117
OMIM: 182860
HGNC: 11272
Ensembl: ENSG00000163554
UniProt: P02549
Structure
Position
1:complement(158610704..158686715)
AA seq 2419 aa
MEQFPKETVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKR
DADDLGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFT
MGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAI
ATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQN
EVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASE
GLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALAT
SRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEID
SYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHL
FYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTAT
KLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINK
KKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTT
RLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLA
EVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKE
PLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILE
NIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQ
FQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRN
QANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAA
DHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQ
RYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKV
ADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIE
KKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDL
QRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAED
LTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDL
EKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLD
KAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYA
NLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVIN
LGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFE
FWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFN
VDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQD
YGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEH
WEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMK
HEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAW
KLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSF
QQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQK
AEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFK
CLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQ
EFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLG
DNLEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKEFSTIY
KHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVSLEDYT
AFLIDKESENIKSSDEIENAFQALAEGKSYITKEDMKQALTPEQVSFCATHMQQYMDPRG
RSHLSGYDYVGFTNSYFGN
NT seq 7260 nt   +upstreamnt  +downstreamnt
atggagcaatttccaaaggaaaccgttgtggagagcagtgggccaaaggttttggaaaca
gcagaagagatccaggagaggcgtcaggaagtgttgactcggtatcaaagtttcaaggag
cgggtcgctgagaggggtcagaagcttgaggattcctatcacttacaagttttcaagcga
gatgcagatgatctggggaagtggatcatggagaaagtcaatatcttaaccgataagagc
tatgaagacccaactaatatacaggggaaatatcagaagcatcaatcccttgaagcagag
gtgcaaacaaaatcaagactcatgtctgaactggaaaaaacaagggaagaacgatttacc
atgggtcattctgcccacgaagaaacgaaggcccatatagaggagctacgccacctgtgg
gacctgctgttagagctgaccctggagaagggtgaccagttgctgcgggccctgaagttc
cagcagtatgtacaggagtgtgctgacatcttagagtggattggagacaaggaggctata
gcgacatcagtggagctaggtgaagactgggagcgcaccgaagttctgcataagaaattt
gaagacttccaagtggagctggtagctaaagaagggagagttgttgaagtgaaccaatat
gccaatgagtgtgccgaggaaaaccatcctgacctacccttaattcagtctaagcaaaat
gaggtgaatgctgcctgggagcgccttcgtggtttggctctccagagacagaaagctctg
tccaatgctgcaaacttacaacgattcaaaagggatgtgactgaagccatccagtggatc
aaggagaaggaacctgtactcacctctgaggactatggcaaagaccttgttgcctctgaa
ggactgtttcacagtcacaagggacttgagagaaatcttgctgtcatgagtgacaaggtg
aaggagttatgtgctaaagcagagaagctgacactttcccatccttcagatgcacctcag
atccaggagatgaaagaagatctggtctccagctgggagcatattcgtgccctggccacc
agcagatatgaaaaactgcaggctacttattggtaccatcgattttcatctgactttgat
gaactctcaggctggatgaacgagaagactgctgcgatcaatgctgatgagctgccaaca
gatgtggctggtggagaagttctgctggacaggcatcagcagcataagcatgagattgac
tcttacgatgaccgatttcaatctgctgatgagactggtcaagacctcgtgaatgccaat
catgaagcctctgatgaagttcgggaaaagatggaaatacttgacaacaactggactgcc
ctgctggaactgtgggacgagcgtcatcgtcagtatgagcagtgcttggactttcatctc
ttctacagagacagtgagcaagtggacagttggatgagtagacaagaggccttcctggaa
aacgaggatctgggaaactcactgggcagtgcagaagcccttcttcagaagcatgaagac
tttgaggaagcctttactgcccaggaagagaagatcataactgtagacaagactgcaacc
aaattgattggtgatgaccattatgattcagagaacatcaaggctatccgtgacgggctg
ttagcccggcgggatgccctacgtgaaaaggctgccactagacgtagattgctgaaggag
tcattgcttctgcaaaaactgtatgaggactcagatgacctaaagaactggatcaacaag
aagaaaaagttggcagatgatgaagattacaaggacatacagaacttgaagagcagggtt
caaaagcagcaagtctttgaaaaggagttggcagttaataagacccagctggaaaacata
cagaaaactggccaagagatgattgagggtggtcactatgcctctgacaatgtgaccact
cgtctgagtgaagttgccagcctctgggaggagttgctggaggctacaaaacagaaaggg
acccagttgcatgaggccaaccagcagctgcaatttgaaaataatgcagaagatttgcag
cgctggctggaggatgttgagtggcaagtcacctctgaggattatgggaaaggcctggcc
gaggtacagaatcgactcaggaaacacggcctcctggagtcggctgtggctgctcgtcag
gatcaggtggatatccttacagacctggctgcatattttgaagaaataggccatcctgat
tctaaggatataagggcaaggcaagagtccttggtatgccgatttgaagctctgaaagag
ccactggccacccgaaagaagaagctcttagaccttctccatctgcagctgatttgtaga
gacacagaggatgaggaggcctggatccaagagactgaaccctcagctacttccacctac
cttggaaaggacctgattgcttccaaaaagcttctgaataggcatagagtcatcctggag
aacattgccagccatgaaccacgcattcaagagataacagaaaggggaaacaaaatggta
gaggaaggacactttgctgcagaagatgtggcctctagggtcaagagtttgaaccagaat
atggagtctctccgtgctcgagctgctaggcgacaaaatgatcttgaagccaatgtccag
ttccagcagtacctggctgacctgcatgaagcagaaacatggatcagagagaaggaacct
attgtagataatactaactatggtgctgatgaagaagcagctggggctcttctaaagaag
catgaggcctttctattagatctcaattcatttggagacagtatgaaagctctgcggaat
caggcaaacgcctgccagcaacaacaggctgcaccagtggagggagttgctggagaacaa
agggtcatggctttatatgacttccaggcccgcagcccccgagaagtcaccatgaagaaa
ggtgatgtcttaacgctgctcagttccatcaataaggactggtggaaggtggaagctgct
gatcatcagggcattgtcccagctgtctatgtcagaagactggcccacgatgagttcccg
atgctcccacagcggcgacgagaagagccaggaaacatcacccagcgccaggagcagatt
gagaaccaataccgctccctcttggatcgggcagaagaacgcagacgtcgtctattgcaa
cgttataatgaatttttattggcctatgaggcaggagacatgctggaatggattcaagag
aaaaaggcagaaaacactggagtggaactagatgatgtttgggagctgcagaaaaagttt
gatgagttccaaaaggatttgaataccaatgagcctcggctaagggatatcaacaaggta
gctgatgatctactatttgaaggacttctaacaccagaaggagctcaaatccggcaggaa
ttgaattcccgctggggttctttgcagaggcttgcagatgaacagcggcagctgctgggc
agtgcccatgctgttgaagtgtttcacagagaagcagatgacacgaaggagcagattgag
aagaaatgccaggccctcagtgctgcagaccctggctcagatctgttcagtgttcaggct
cttcagcgacggcatgagggctttgaaagggacctcgtacccctgggagataaggtgacc
atactgggggagacagcagagcggctcagtgagtcccatccagatgccactgaggacctg
cagagacagaaaatggagctgaatgaggcctgggaagacctgcaggggcgtacaaaggat
cgtaaggagagcctaaatgaggcccagaaattctacctgttcctcagcaaggccagggat
ctgcagaactggatcagtagcattggtggcatggtatcatcacaggagctggccgaagac
ttaactggcatagagatcttgctggagagacatcaggagcaccgtgctgacatggaggca
gaggctcccaccttccaggccttagaggacttcagtgcagaacttatcgacagtgggcac
catgctagccctgaaattgaaaaaaagcttcaagctgtcaagctagagagagatgatttg
gagaaggcttgggaaaaacgcaagaagatcctagaccagtgcctggagttgcagatgttc
caggggaactgtgatcaagttgagagctggatggtggcacgtgagaattccctgaggtca
gatgacaaaagttccttagacagtctggaggctttgatgaagaaacgggacgatttggac
aaagcaatcactgcccaggaagggaagatcactgacctagaacattttgctgagagcctc
attgctgatgaacactatgccaaagaagagattgctacgcggctccaacgtgtactagac
aggtggaaggctctcaaagcacaactgattgatgagcggacaaagcttggagactatgcc
aacctaaaacaattctaccgagaccttgaggagctggaagaatggatcagtgagatgctg
cccacagcctgtgatgaatcctacaaagacgccactaacattcagaggaaatacctgaaa
caccagacctttgcacatgaagtcgatggccgatctgagcaggtgcatggcgtcatcaac
ctggggaactccctgattgagtgtagcgcttgtgatggcaatgaagaggccatgaaggag
caactggaacagctgaaggaacattgggatcatctgcttgagagaacaaatgacaaaggg
aagaagctcaatgaggccagtcgtcaacagaggttcaacacaagcatccgggactttgag
ttctggctctcagaggcagagacattgctggccatgaaagatcaggccagggacttggct
tcagcaggaaacctactcaagaagcatcagctattggagagagagatgttggctcgagag
gatgcactcaaggacctgaatacattggctgaagatttgctctccagcgggactttcaac
gttgatcagattgtgaagaaaaaagataatgtcaacaagcgtttcctgaatgtccaagaa
ttggcagctgcacaccacgaaaaattgaaagaggcctatgccttgttccagttcttccag
gatctagatgatgaggaatcctggatagaggagaagttgatacgagtgagctcccaggac
tatgggagagatcttcagggggttcagaacttgctgaagaagcacaaacgcctagagggg
gagctggtggcccatgagcctgccatccagaatgtgctggatatggcagagaagctgaaa
gacaaggctgctgtggggcaagaggagatccagttgcggctggctcagtttgttgaacac
tgggagaagctcaaagagttggccaaggcccgaggacttaagttggaagaatccctagaa
tacttgcaattcatgcagaatgctgaggaagaggaagcttggatcaatgaaaagaatgct
ttggctgtccgaggagattgtggagatacattagctgctactcagagcttgctaatgaag
catgaagctttggaaaatgactttgctgtccatgagacccgagtacaaaatgtgtgtgca
caaggagaagacatcctaaataaggtgttgcaggaggaaagtcagaacaaagagatttct
tccaagatagaggctctgaatgaaaagaccccttctctggctaaggcaatagctgcttgg
aagttgcaattggaagacgattatgcctttcaggaattcaactggaaggctgatgtggta
gaggcttggatagctgataaggaaacaagcctaaagaccaatggcaatggtgcagacctt
ggtgacttcctcactcttctggcaaaacaggacactctggatgccagtctgcagagtttc
cagcaagagagacttcccgagatcactgacctgaaggacaaactgatttctgctcaacac
aaccagtctaaagccattgaagagcgttatgccgctctgctgaagcgctgggaacagttg
ctggaagcctcggcagtccacagacagaaattgctggagaaacagctgcctctacagaag
gctgaggacctgttcgtggaatttgcacataaggcttcagctttgaacaactggtgtgaa
aagatggaagaaaacttgtcagagcctgtgcactgtgtctccctgaatgaaattcggcag
ctgcagaaagaccatgaggacttcttggcctccctggctagggctcaagcagactttaaa
tgtttgctggagctagaccagcagattaaggccttaggtgtgccttccagcccttatacc
tggttaacagtggaggtgctggaaaggacctggaagcacctatctgacatcattgaggaa
cgggagcaggagctgcaaaaggaagaggcaagacaggtcaagaactttgagatgtgtcag
gagtttgaacagaatgccagtaccttccttcaatggatcctggaaaccagggcttacttt
ctggatggatcattgctcaaagaaacaggaactctggaatctcagctggaagcaaataaa
agaaaacagaaggagatccaggcgatgaagcgtcaactaaccaagattgtggacctgggg
gacaacttggaagacgctctgatccttgatatcaaatacagcaccattggattggctcag
cagtgggaccagctctaccagcttgggttgcggatgcaacacaacctggagcaacagatc
caggccaaggacatcaaaggtgtgagtgaagagactctaaaggaatttagcacaatctat
aaacactttgatgagaatttgacagggcgcctgactcacaaagagttccggtcctgcctg
agaggactcaattactacttgcccatggtggaggaggatgaacatgagcccaagtttgag
aagttcctggatgctgtggatccagggaggaagggctatgtctcactggaggactatact
gctttcctgattgacaaggagtcagaaaacatcaagtccagtgatgaaatagagaatgcc
ttccaagccctggcagagggcaagtcatatattaccaaagaagacatgaagcaggccctt
accccagagcaagtgtcattctgtgccacacatatgcagcaatatatggacccacggggt
cgaagccatctctctggctatgactacgttggcttcaccaattcctactttggcaactaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Disease (7)   
   KEGG DISEASE (3)   
   OMIM (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (47)   
   KEGG ORTHOLOGY (1)   
   RefGene (34)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PROTHERM (7)   
Protein sequence (14)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (12)   
DNA sequence (24)   
   RefSeq(nuc) (14)   
   GenBank (5)   
   EMBL (5)   
3D Structure (3)   
   PDB (3)   
Protein domain (10)   
   Pfam (10)   
All databases (108)   

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