KEGG T01001: 7097

Homo sapiens (human): 7097

Entry

7097              CDS       T01001

Symbol

TLR2, CD282, TIL4

Name

(RefSeq) toll like receptor 2

K10159

toll-like receptor 2

Organism

hsa Homo sapiens (human)

Pathway

hsa04145

Phagosome

hsa04151

PI3K-Akt signaling pathway

hsa04613

Neutrophil extracellular trap formation

hsa04620

Toll-like receptor signaling pathway

hsa05132

Salmonella infection

hsa05134

Legionellosis

hsa05140

Leishmaniasis

hsa05142

Chagas disease

hsa05144

Malaria

hsa05145

Toxoplasmosis

hsa05146

Amoebiasis

hsa05152

Tuberculosis

hsa05161

Hepatitis B

hsa05162

Measles

hsa05168

Herpes simplex virus 1 infection

hsa05169

Epstein-Barr virus infection

hsa05170

Human immunodeficiency virus 1 infection

hsa05171

Coronavirus disease - COVID-19

hsa05205

Proteoglycans in cancer

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

hsa05321

Inflammatory bowel disease

hsa05323

Rheumatoid arthritis

hsa05417

Lipid and atherosclerosis

Network

nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06165  Epstein-Barr virus (EBV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06180  Pathogenic Escherichia coli
nt06182  Shigella
nt06183  Yersinia
nt06263  Hepatocellular carcinoma
nt06517  TLR signaling

Element

N00435

TLR1/2/4-NFKB signaling pathway

N00438

TLR2/4-MAPK signaling pathway

N00556

HBV HBe to TLR2/4-NFKB signaling pathway

Disease

H00342

Tuberculosis

H00344

Leprosy

Drug target

Tomaralimab:

D11503

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    7097 (TLR2)
09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    7097 (TLR2)
09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    7097 (TLR2)
   04620 Toll-like receptor signaling pathway
    7097 (TLR2)
09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    7097 (TLR2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    7097 (TLR2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    7097 (TLR2)
   05161 Hepatitis B
    7097 (TLR2)
   05171 Coronavirus disease - COVID-19
    7097 (TLR2)
   05162 Measles
    7097 (TLR2)
   05168 Herpes simplex virus 1 infection
    7097 (TLR2)
   05169 Epstein-Barr virus infection
    7097 (TLR2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    7097 (TLR2)
   05134 Legionellosis
    7097 (TLR2)
   05152 Tuberculosis
    7097 (TLR2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    7097 (TLR2)
   05144 Malaria
    7097 (TLR2)
   05145 Toxoplasmosis
    7097 (TLR2)
   05140 Leishmaniasis
    7097 (TLR2)
   05142 Chagas disease
    7097 (TLR2)
  09163 Immune disease
   05323 Rheumatoid arthritis
    7097 (TLR2)
   05321 Inflammatory bowel disease
    7097 (TLR2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    7097 (TLR2)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    7097 (TLR2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    7097 (TLR2)
   04054 Pattern recognition receptors [BR:hsa04054]
    7097 (TLR2)
   04090 CD molecules [BR:hsa04090]
    7097 (TLR2)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    7097 (TLR2)
Membrane trafficking [BR:hsa04131]
Endocytosis
  Phagocytosis
   Toll-like receptors
    7097 (TLR2)
Exosome [BR:hsa04147]
Exosomal proteins
  Exosomal proteins of breast milk
   7097 (TLR2)
Pattern recognition receptors [BR:hsa04054]
Membrane-bound pattern recognition receptors
  Toll-like receptors
   7097 (TLR2)
CD molecules [BR:hsa04090]
Proteins
  7097 (TLR2)
Glycosaminoglycan binding proteins [BR:hsa00536]
Hyaluronan
  Cell surface receptors
   7097 (TLR2)

SSDB

Motif

Pfam:

LRR_8 LRR_4 TIR TIR_2 LRR_9 LRR_5 LRR_1 LRRCT TANGO2

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

O60603 B3KWR9 A0A0S2Z4S4

Structure

Position

4:153684280..153710637

AA seq 784 aa
MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLS
NNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWF
KPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELE
IDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFS
ELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDN
DRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLK
SLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDI
SKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLK
ELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCE
FLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFL
LILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMV
QELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFS
HFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRA
AIKS

NT seq 2355 nt +upstreamnt +downstreamnt
atgccacatactttgtggatggtgtgggtcttgggggtcatcatcagcctctccaaggaa
gaatcctccaatcaggcttctctgtcttgtgaccgcaatggtatctgcaagggcagctca
ggatctttaaactccattccctcagggctcacagaagctgtaaaaagccttgacctgtcc
aacaacaggatcacctacattagcaacagtgacctacagaggtgtgtgaacctccaggct
ctggtgctgacatccaatggaattaacacaatagaggaagattctttttcttccctgggc
agtcttgaacatttagacttatcctataattacttatctaatttatcgtcttcctggttc
aagcccctttcttctttaacattcttaaacttactgggaaatccttacaaaaccctaggg
gaaacatctcttttttctcatctcacaaaattgcaaatcctgagagtgggaaatatggac
accttcactaagattcaaagaaaagattttgctggacttaccttccttgaggaacttgag
attgatgcttcagatctacagagctatgagccaaaaagtttgaagtcaattcagaatgta
agtcatctgatccttcatatgaagcagcatattttactgctggagatttttgtagatgtt
acaagttccgtggaatgtttggaactgcgagatactgatttggacactttccatttttca
gaactatccactggtgaaacaaattcattgattaaaaagtttacatttagaaatgtgaaa
atcaccgatgaaagtttgtttcaggttatgaaacttttgaatcagatttctggattgtta
gaattagagtttgatgactgtacccttaatggagttggtaattttagagcatctgataat
gacagagttatagatccaggtaaagtggaaacgttaacaatccggaggctgcatattcca
aggttttacttattttatgatctgagcactttatattcacttacagaaagagttaaaaga
atcacagtagaaaacagtaaagtttttctggttccttgtttactttcacaacatttaaaa
tcattagaatacttggatctcagtgaaaatttgatggttgaagaatacttgaaaaattca
gcctgtgaggatgcctggccctctctacaaactttaattttaaggcaaaatcatttggca
tcattggaaaaaaccggagagactttgctcactctgaaaaacttgactaacattgatatc
agtaagaatagttttcattctatgcctgaaacttgtcagtggccagaaaagatgaaatat
ttgaacttatccagcacacgaatacacagtgtaacaggctgcattcccaagacactggaa
attttagatgttagcaacaacaatctcaatttattttctttgaatttgccgcaactcaaa
gaactttatatttccagaaataagttgatgactctaccagatgcctccctcttacccatg
ttactagtattgaaaatcagtaggaatgcaataactacgttttctaaggagcaacttgac
tcatttcacacactgaagactttggaagctggtggcaataacttcatttgctcctgtgaa
ttcctctccttcactcaggagcagcaagcactggccaaagtcttgattgattggccagca
aattacctgtgtgactctccatcccatgtgcgtggccagcaggttcaggatgtccgcctc
tcggtgtcggaatgtcacaggacagcactggtgtctggcatgtgctgtgctctgttcctg
ctgatcctgctcacgggggtcctgtgccaccgtttccatggcctgtggtatatgaaaatg
atgtgggcctggctccaggccaaaaggaagcccaggaaagctcccagcaggaacatctgc
tatgatgcatttgtttcttacagtgagcgggatgcctactgggtggagaaccttatggtc
caggagctggagaacttcaatccccccttcaagttgtgtcttcataagcgggacttcatt
cctggcaagtggatcattgacaatatcattgactccattgaaaagagccacaaaactgtc
tttgtgctttctgaaaactttgtgaagagtgagtggtgcaagtatgaactggacttctcc
catttccgtctttttgatgagaacaatgatgctgccattctcattcttctggagcccatt
gagaaaaaagccattccccagcgcttctgcaagctgcggaagataatgaacaccaagacc
tacctggagtggcccatggacgaggctcagcgggaaggattttgggtaaatctgagagct
gcgataaagtcctag

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