KEGG   Homo sapiens (human): 718
Entry
718               CDS       T01001                                 
Symbol
C3, AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, HEL-S-62p
Name
(RefSeq) complement C3
  KO
K03990  complement component 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04145  Phagosome
hsa04610  Complement and coagulation cascades
hsa04613  Neutrophil extracellular trap formation
hsa04936  Alcoholic liver disease
hsa05131  Shigellosis
hsa05133  Pertussis
hsa05134  Legionellosis
hsa05140  Leishmaniasis
hsa05142  Chagas disease
hsa05150  Staphylococcus aureus infection
hsa05152  Tuberculosis
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05171  Coronavirus disease - COVID-19
hsa05203  Viral carcinogenesis
hsa05322  Systemic lupus erythematosus
Network
nt06168  Herpes simplex virus 1 (HSV-1)
nt06182  Shigella
nt06513  Complement cascade
nt06532  Autophagy
  Element
N01284  Shigella IcsP to Autophagy-vesicle elongation
N01489  Classical/Lectin pathway of complement cascade, C5 convertase formation
N01493  Alternative pathway of complement cascade, C3 convertase formation
N01494  Alternative pathway of complement cascade, C3/5 convertase formation
Disease
H00102  Classic complement pathway component defects
H00821  Age-related macular degeneration
H01434  Atypical hemolytic uremic syndrome
Drug target
Pegcetacoplan: D11613<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    718 (C3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    718 (C3)
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    718 (C3)
   04613 Neutrophil extracellular trap formation
    718 (C3)
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    718 (C3)
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    718 (C3)
   05168 Herpes simplex virus 1 infection
    718 (C3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    718 (C3)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    718 (C3)
   05133 Pertussis
    718 (C3)
   05134 Legionellosis
    718 (C3)
   05150 Staphylococcus aureus infection
    718 (C3)
   05152 Tuberculosis
    718 (C3)
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    718 (C3)
   05142 Chagas disease
    718 (C3)
  09163 Immune disease
   05322 Systemic lupus erythematosus
    718 (C3)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    718 (C3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    718 (C3)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    718 (C3)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    718 (C3)
Peptidases and inhibitors [BR:hsa01002]
 Peptidase inhibitors
  Family I39: alpha2M family
   718 (C3)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Phagocytosis
   Opsonins
    718 (C3)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other cancer cells
   718 (C3)
SSDB
Motif
Pfam: TED_complement A2M_recep C3_CUB2 MG4 MG1 NTR A2M_BRD A2M MG2 MG3 ANATO C3_CUB1
Other DBs
NCBI-GeneID: 718
NCBI-ProteinID: NP_000055
OMIM: 120700
HGNC: 1318
Ensembl: ENSG00000125730
CPD: C02002 C22539 C22533 C22536 C22537 C22538 C22534 C22535
UniProt: P01024 V9HWA9 B4DR57
Structure
Position
19:complement(6677704..6720650)
AA seq 1663 aa
MGPTSGPSLLLLLLTHLPLALGSPMYSIITPNILRLESEETMVLEAHDAQGDVPVTVTVH
DFPGKKLVLSSEKTVLTPATNHMGNVTFTIPANREFKSEKGRNKFVTVQATFGTQVVEKV
VLVSLQSGYLFIQTDKTIYTPGSTVLYRIFTVNHKLLPVGRTVMVNIENPEGIPVKQDSL
SSQNQLGVLPLSWDIPELVNMGQWKIRAYYENSPQQVFSTEFEVKEYVLPSFEVIVEPTE
KFYYIYNEKGLEVTITARFLYGKKVEGTAFVIFGIQDGEQRISLPESLKRIPIEDGSGEV
VLSRKVLLDGVQNPRAEDLVGKSLYVSATVILHSGSDMVQAERSGIPIVTSPYQIHFTKT
PKYFKPGMPFDLMVFVTNPDGSPAYRVPVAVQGEDTVQSLTQGDGVAKLSINTHPSQKPL
SITVRTKKQELSEAEQATRTMQALPYSTVGNSNNYLHLSVLRTELRPGETLNVNFLLRMD
RAHEAKIRYYTYLIMNKGRLLKAGRQVREPGQDLVVLPLSITTDFIPSFRLVAYYTLIGA
SGQREVVADSVWVDVKDSCVGSLVVKSGQSEDRQPVPGQQMTLKIEGDHGARVVLVAVDK
GVFVLNKKNKLTQSKIWDVVEKADIGCTPGSGKDYAGVFSDAGLTFTSSSGQQTAQRAEL
QCPQPAARRRRSVQLTEKRMDKVGKYPKELRKCCEDGMRENPMRFSCQRRTRFISLGEAC
KKVFLDCCNYITELRRQHARASHLGLARSNLDEDIIAEENIVSRSEFPESWLWNVEDLKE
PPKNGISTKLMNIFLKDSITTWEILAVSMSDKKGICVADPFEVTVMQDFFIDLRLPYSVV
RNEQVEIRAVLYNYRQNQELKVRVELLHNPAFCSLATTKRRHQQTVTIPPKSSLSVPYVI
VPLKTGLQEVEVKAAVYHHFISDGVRKSLKVVPEGIRMNKTVAVRTLDPERLGREGVQKE
DIPPADLSDQVPDTESETRILLQGTPVAQMTEDAVDAERLKHLIVTPSGCGEQNMIGMTP
TVIAVHYLDETEQWEKFGLEKRQGALELIKKGYTQQLAFRQPSSAFAAFVKRAPSTWLTA
YVVKVFSLAVNLIAIDSQVLCGAVKWLILEKQKPDGVFQEDAPVIHQEMIGGLRNNNEKD
MALTAFVLISLQEAKDICEEQVNSLPGSITKAGDFLEANYMNLQRSYTVAIAGYALAQMG
RLKGPLLNKFLTTAKDKNRWEDPGKQLYNVEATSYALLALLQLKDFDFVPPVVRWLNEQR
YYGGGYGSTQATFMVFQALAQYQKDAPDHQELNLDVSLQLPSRSSKITHRIHWESASLLR
SEETKENEGFTVTAEGKGQGTLSVVTMYHAKAKDQLTCNKFDLKVTIKPAPETEKRPQDA
KNTMILEICTRYRGDQDATMSILDISMMTGFAPDTDDLKQLANGVDRYISKYELDKAFSD
RNTLIIYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVYAYYNLEESCTRFYHPEKEDG
KLNKLCRDELCRCAEENCFIQKSDDKVTLEERLDKACEPGVDYVYKTRLVKVQLSNDFDE
YIMAIEQTIKSGSDEVQVGQQRTFISPIKCREALKLEEKKHYLMWGLSSDFWGEKPNLSY
IIGKDTWVEHWPEEDECQDEENQKQCQDLGAFTESMVVFGCPN
NT seq 4992 nt   +upstreamnt  +downstreamnt
atgggacccacctcaggtcccagcctgctgctcctgctactaacccacctccccctggct
ctggggagtcccatgtactctatcatcacccccaacatcttgcggctggagagcgaggag
accatggtgctggaggcccacgacgcgcaaggggatgttccagtcactgttactgtccac
gacttcccaggcaaaaaactagtgctgtccagtgagaagactgtgctgacccctgccacc
aaccacatgggcaacgtcaccttcacgatcccagccaacagggagttcaagtcagaaaag
gggcgcaacaagttcgtgaccgtgcaggccaccttcgggacccaagtggtggagaaggtg
gtgctggtcagcctgcagagcgggtacctcttcatccagacagacaagaccatctacacc
cctggctccacagttctctatcggatcttcaccgtcaaccacaagctgctacccgtgggc
cggacggtcatggtcaacattgagaacccggaaggcatcccggtcaagcaggactccttg
tcttctcagaaccagcttggcgtcttgcccttgtcttgggacattccggaactcgtcaac
atgggccagtggaagatccgagcctactatgaaaactcaccacagcaggtcttctccact
gagtttgaggtgaaggagtacgtgctgcccagtttcgaggtcatagtggagcctacagag
aaattctactacatctataacgagaagggcctggaggtcaccatcaccgccaggttcctc
tacgggaagaaagtggagggaactgcctttgtcatcttcgggatccaggatggcgaacag
aggatttccctgcctgaatccctcaagcgcattccgattgaggatggctcgggggaggtt
gtgctgagccggaaggtactgctggacggggtgcagaacccccgagcagaagacctggtg
gggaagtctttgtacgtgtctgccaccgtcatcttgcactcaggcagtgacatggtgcag
gcagagcgcagcgggatccccatcgtgacctctccctaccagatccacttcaccaagaca
cccaagtacttcaaaccaggaatgccctttgacctcatggtgttcgtgacgaaccctgat
ggctctccagcctaccgagtccccgtggcagtccagggcgaggacactgtgcagtctcta
acccagggagatggcgtggccaaactcagcatcaacacacaccccagccagaagcccttg
agcatcacggtgcgcacgaagaagcaggagctctcggaggcagagcaggctaccaggacc
atgcaggctctgccctacagcaccgtgggcaactccaacaattacctgcatctctcagtg
ctacgtacagagctcagacccggggagaccctcaacgtcaacttcctcctgcgaatggac
cgcgcccacgaggccaagatccgctactacacctacctgatcatgaacaagggcaggctg
ttgaaggcgggacgccaggtgcgagagcccggccaggacctggtggtgctgcccctgtcc
atcaccaccgacttcatcccttccttccgcctggtggcgtactacacgctgatcggtgcc
agcggccagagggaggtggtggccgactccgtgtgggtggacgtcaaggactcctgcgtg
ggctcgctggtggtaaaaagcggccagtcagaagaccggcagcctgtacctgggcagcag
atgaccctgaagatagagggtgaccacggggcccgggtggtactggtggccgtggacaag
ggcgtgttcgtgctgaataagaagaacaaactgacgcagagtaagatctgggacgtggtg
gagaaggcagacatcggctgcaccccgggcagtgggaaggattacgccggtgtcttctcc
gacgcagggctgaccttcacgagcagcagtggccagcagaccgcccagagggcagaactt
cagtgcccgcagccagccgcccgccgacgccgttccgtgcagctcacggagaagcgaatg
gacaaagtcggcaagtaccccaaggagctgcgcaagtgctgcgaggacggcatgcgggag
aaccccatgaggttctcgtgccagcgccggacccgtttcatctccctgggcgaggcgtgc
aagaaggtcttcctggactgctgcaactacatcacagagctgcggcggcagcacgcgcgg
gccagccacctgggcctggccaggagtaacctggatgaggacatcattgcagaagagaac
atcgtttcccgaagtgagttcccagagagctggctgtggaacgttgaggacttgaaagag
ccaccgaaaaatggaatctctacgaagctcatgaatatatttttgaaagactccatcacc
acgtgggagattctggctgtgagcatgtcggacaagaaagggatctgtgtggcagacccc
ttcgaggtcacagtaatgcaggacttcttcatcgacctgcggctaccctactctgttgtt
cgaaacgagcaggtggaaatccgagccgttctctacaattaccggcagaaccaagagctc
aaggtgagggtggaactactccacaatccagccttctgcagcctggccaccaccaagagg
cgtcaccagcagaccgtaaccatcccccccaagtcctcgttgtccgttccatatgtcatc
gtgccgctaaagaccggcctgcaggaagtggaagtcaaggctgctgtctaccatcatttc
atcagtgacggtgtcaggaagtccctgaaggtcgtgccggaaggaatcagaatgaacaaa
actgtggctgttcgcaccctggatccagaacgcctgggccgtgaaggagtgcagaaagag
gacatcccacctgcagacctcagtgaccaagtcccggacaccgagtctgagaccagaatt
ctcctgcaagggaccccagtggcccagatgacagaggatgccgtcgacgcggaacggctg
aagcacctcattgtgaccccctcgggctgcggggaacagaacatgatcggcatgacgccc
acggtcatcgctgtgcattacctggatgaaacggagcagtgggagaagttcggcctagag
aagcggcagggggccttggagctcatcaagaaggggtacacccagcagctggccttcaga
caacccagctctgcctttgcggccttcgtgaaacgggcacccagcacctggctgaccgcc
tacgtggtcaaggtcttctctctggctgtcaacctcatcgccatcgactcccaagtcctc
tgcggggctgttaaatggctgatcctggagaagcagaagcccgacggggtcttccaggag
gatgcgcccgtgatacaccaagaaatgattggtggattacggaacaacaacgagaaagac
atggccctcacggcctttgttctcatctcgctgcaggaggctaaagatatttgcgaggag
caggtcaacagcctgccaggcagcatcactaaagcaggagacttccttgaagccaactac
atgaacctacagagatcctacactgtggccattgctggctatgctctggcccagatgggc
aggctgaaggggcctcttcttaacaaatttctgaccacagccaaagataagaaccgctgg
gaggaccctggtaagcagctctacaacgtggaggccacatcctatgccctcttggcccta
ctgcagctaaaagactttgactttgtgcctcccgtcgtgcgttggctcaatgaacagaga
tactacggtggtggctatggctctacccaggccaccttcatggtgttccaagccttggct
caataccaaaaggacgcccctgaccaccaggaactgaaccttgatgtgtccctccaactg
cccagccgcagctccaagatcacccaccgtatccactgggaatctgccagcctcctgcga
tcagaagagaccaaggaaaatgagggtttcacagtcacagctgaaggaaaaggccaaggc
accttgtcggtggtgacaatgtaccatgctaaggccaaagatcaactcacctgtaataaa
ttcgacctcaaggtcaccataaaaccagcaccggaaacagaaaagaggcctcaggatgcc
aagaacactatgatccttgagatctgtaccaggtaccggggagaccaggatgccactatg
tctatattggacatatccatgatgactggctttgctccagacacagatgacctgaagcag
ctggccaatggtgttgacagatacatctccaagtatgagctggacaaagccttctccgat
aggaacaccctcatcatctacctggacaaggtctcacactctgaggatgactgtctagct
ttcaaagttcaccaatactttaatgtagagcttatccagcctggagcagtcaaggtctac
gcctattacaacctggaggaaagctgtacccggttctaccatccggaaaaggaggatgga
aagctgaacaagctctgccgtgatgaactgtgccgctgtgctgaggagaattgcttcata
caaaagtcggatgacaaggtcaccctggaagaacggctggacaaggcctgtgagccagga
gtggactatgtgtacaagacccgactggtcaaggttcagctgtccaatgactttgacgag
tacatcatggccattgagcagaccatcaagtcaggctcggatgaggtgcaggttggacag
cagcgcacgttcatcagccccatcaagtgcagagaagccctgaagctggaggagaagaaa
cactacctcatgtggggtctctcctccgatttctggggagagaagcccaacctcagctac
atcatcgggaaggacacttgggtggagcactggcccgaggaggacgaatgccaagacgaa
gagaaccagaaacaatgccaggacctcggcgccttcaccgagagcatggttgtctttggg
tgccccaactga

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