Entry |
|
Symbol |
C3, AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, HEL-S-62p
|
Name |
|
KO |
|
Organism |
|
Pathway |
hsa04080 | Neuroactive ligand-receptor interaction |
hsa04610 | Complement and coagulation cascades |
hsa04613 | Neutrophil extracellular trap formation |
hsa05150 | Staphylococcus aureus infection |
hsa05167 | Kaposi sarcoma-associated herpesvirus infection |
hsa05168 | Herpes simplex virus 1 infection |
|
Network |
|
Element |
N01284 | Shigella IcsP to Autophagy-vesicle elongation |
N01489 | Classical/Lectin pathway of complement cascade, C5 convertase formation |
N01493 | Alternative pathway of complement cascade, C3 convertase formation |
N01494 | Alternative pathway of complement cascade, C3/5 convertase formation |
|
Disease |
H00102 | Classic complement pathway component defects |
H00821 | Age-related macular degeneration |
H01434 | Atypical hemolytic uremic syndrome |
|
Drug target |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09133 Signaling molecules and interaction
04080 Neuroactive ligand-receptor interaction
718 (C3)
09140 Cellular Processes
09141 Transport and catabolism
04145 Phagosome
718 (C3)
09150 Organismal Systems
09151 Immune system
04610 Complement and coagulation cascades
718 (C3)
04613 Neutrophil extracellular trap formation
718 (C3)
09160 Human Diseases
09161 Cancer: overview
05203 Viral carcinogenesis
718 (C3)
09172 Infectious disease: viral
05171 Coronavirus disease - COVID-19
718 (C3)
05168 Herpes simplex virus 1 infection
718 (C3)
05167 Kaposi sarcoma-associated herpesvirus infection
718 (C3)
09171 Infectious disease: bacterial
05131 Shigellosis
718 (C3)
05133 Pertussis
718 (C3)
05134 Legionellosis
718 (C3)
05150 Staphylococcus aureus infection
718 (C3)
05152 Tuberculosis
718 (C3)
09174 Infectious disease: parasitic
05140 Leishmaniasis
718 (C3)
05142 Chagas disease
718 (C3)
09163 Immune disease
05322 Systemic lupus erythematosus
718 (C3)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
718 (C3)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:hsa01002]
718 (C3)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:hsa04131]
718 (C3)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:hsa04147]
718 (C3)
Peptidases and inhibitors [BR:hsa01002]
Peptidase inhibitors
Family I39: alpha2M family
718 (C3)
Membrane trafficking [BR:hsa04131]
Endocytosis
Phagocytosis
Opsonins
718 (C3)
Exosome [BR:hsa04147]
Exosomal proteins
Exosomal proteins of other cancer cells
718 (C3)
|
SSDB |
|
Motif |
|
Other DBs |
|
Structure |
|
Position |
19:complement(6677704..6720650)
|
AA seq |
1663 aa
MGPTSGPSLLLLLLTHLPLALGSPMYSIITPNILRLESEETMVLEAHDAQGDVPVTVTVH
DFPGKKLVLSSEKTVLTPATNHMGNVTFTIPANREFKSEKGRNKFVTVQATFGTQVVEKV
VLVSLQSGYLFIQTDKTIYTPGSTVLYRIFTVNHKLLPVGRTVMVNIENPEGIPVKQDSL
SSQNQLGVLPLSWDIPELVNMGQWKIRAYYENSPQQVFSTEFEVKEYVLPSFEVIVEPTE
KFYYIYNEKGLEVTITARFLYGKKVEGTAFVIFGIQDGEQRISLPESLKRIPIEDGSGEV
VLSRKVLLDGVQNPRAEDLVGKSLYVSATVILHSGSDMVQAERSGIPIVTSPYQIHFTKT
PKYFKPGMPFDLMVFVTNPDGSPAYRVPVAVQGEDTVQSLTQGDGVAKLSINTHPSQKPL
SITVRTKKQELSEAEQATRTMQALPYSTVGNSNNYLHLSVLRTELRPGETLNVNFLLRMD
RAHEAKIRYYTYLIMNKGRLLKAGRQVREPGQDLVVLPLSITTDFIPSFRLVAYYTLIGA
SGQREVVADSVWVDVKDSCVGSLVVKSGQSEDRQPVPGQQMTLKIEGDHGARVVLVAVDK
GVFVLNKKNKLTQSKIWDVVEKADIGCTPGSGKDYAGVFSDAGLTFTSSSGQQTAQRAEL
QCPQPAARRRRSVQLTEKRMDKVGKYPKELRKCCEDGMRENPMRFSCQRRTRFISLGEAC
KKVFLDCCNYITELRRQHARASHLGLARSNLDEDIIAEENIVSRSEFPESWLWNVEDLKE
PPKNGISTKLMNIFLKDSITTWEILAVSMSDKKGICVADPFEVTVMQDFFIDLRLPYSVV
RNEQVEIRAVLYNYRQNQELKVRVELLHNPAFCSLATTKRRHQQTVTIPPKSSLSVPYVI
VPLKTGLQEVEVKAAVYHHFISDGVRKSLKVVPEGIRMNKTVAVRTLDPERLGREGVQKE
DIPPADLSDQVPDTESETRILLQGTPVAQMTEDAVDAERLKHLIVTPSGCGEQNMIGMTP
TVIAVHYLDETEQWEKFGLEKRQGALELIKKGYTQQLAFRQPSSAFAAFVKRAPSTWLTA
YVVKVFSLAVNLIAIDSQVLCGAVKWLILEKQKPDGVFQEDAPVIHQEMIGGLRNNNEKD
MALTAFVLISLQEAKDICEEQVNSLPGSITKAGDFLEANYMNLQRSYTVAIAGYALAQMG
RLKGPLLNKFLTTAKDKNRWEDPGKQLYNVEATSYALLALLQLKDFDFVPPVVRWLNEQR
YYGGGYGSTQATFMVFQALAQYQKDAPDHQELNLDVSLQLPSRSSKITHRIHWESASLLR
SEETKENEGFTVTAEGKGQGTLSVVTMYHAKAKDQLTCNKFDLKVTIKPAPETEKRPQDA
KNTMILEICTRYRGDQDATMSILDISMMTGFAPDTDDLKQLANGVDRYISKYELDKAFSD
RNTLIIYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVYAYYNLEESCTRFYHPEKEDG
KLNKLCRDELCRCAEENCFIQKSDDKVTLEERLDKACEPGVDYVYKTRLVKVQLSNDFDE
YIMAIEQTIKSGSDEVQVGQQRTFISPIKCREALKLEEKKHYLMWGLSSDFWGEKPNLSY
IIGKDTWVEHWPEEDECQDEENQKQCQDLGAFTESMVVFGCPN |
NT seq |
4992 nt +upstreamnt +downstreamnt
atgggacccacctcaggtcccagcctgctgctcctgctactaacccacctccccctggct
ctggggagtcccatgtactctatcatcacccccaacatcttgcggctggagagcgaggag
accatggtgctggaggcccacgacgcgcaaggggatgttccagtcactgttactgtccac
gacttcccaggcaaaaaactagtgctgtccagtgagaagactgtgctgacccctgccacc
aaccacatgggcaacgtcaccttcacgatcccagccaacagggagttcaagtcagaaaag
gggcgcaacaagttcgtgaccgtgcaggccaccttcgggacccaagtggtggagaaggtg
gtgctggtcagcctgcagagcgggtacctcttcatccagacagacaagaccatctacacc
cctggctccacagttctctatcggatcttcaccgtcaaccacaagctgctacccgtgggc
cggacggtcatggtcaacattgagaacccggaaggcatcccggtcaagcaggactccttg
tcttctcagaaccagcttggcgtcttgcccttgtcttgggacattccggaactcgtcaac
atgggccagtggaagatccgagcctactatgaaaactcaccacagcaggtcttctccact
gagtttgaggtgaaggagtacgtgctgcccagtttcgaggtcatagtggagcctacagag
aaattctactacatctataacgagaagggcctggaggtcaccatcaccgccaggttcctc
tacgggaagaaagtggagggaactgcctttgtcatcttcgggatccaggatggcgaacag
aggatttccctgcctgaatccctcaagcgcattccgattgaggatggctcgggggaggtt
gtgctgagccggaaggtactgctggacggggtgcagaacccccgagcagaagacctggtg
gggaagtctttgtacgtgtctgccaccgtcatcttgcactcaggcagtgacatggtgcag
gcagagcgcagcgggatccccatcgtgacctctccctaccagatccacttcaccaagaca
cccaagtacttcaaaccaggaatgccctttgacctcatggtgttcgtgacgaaccctgat
ggctctccagcctaccgagtccccgtggcagtccagggcgaggacactgtgcagtctcta
acccagggagatggcgtggccaaactcagcatcaacacacaccccagccagaagcccttg
agcatcacggtgcgcacgaagaagcaggagctctcggaggcagagcaggctaccaggacc
atgcaggctctgccctacagcaccgtgggcaactccaacaattacctgcatctctcagtg
ctacgtacagagctcagacccggggagaccctcaacgtcaacttcctcctgcgaatggac
cgcgcccacgaggccaagatccgctactacacctacctgatcatgaacaagggcaggctg
ttgaaggcgggacgccaggtgcgagagcccggccaggacctggtggtgctgcccctgtcc
atcaccaccgacttcatcccttccttccgcctggtggcgtactacacgctgatcggtgcc
agcggccagagggaggtggtggccgactccgtgtgggtggacgtcaaggactcctgcgtg
ggctcgctggtggtaaaaagcggccagtcagaagaccggcagcctgtacctgggcagcag
atgaccctgaagatagagggtgaccacggggcccgggtggtactggtggccgtggacaag
ggcgtgttcgtgctgaataagaagaacaaactgacgcagagtaagatctgggacgtggtg
gagaaggcagacatcggctgcaccccgggcagtgggaaggattacgccggtgtcttctcc
gacgcagggctgaccttcacgagcagcagtggccagcagaccgcccagagggcagaactt
cagtgcccgcagccagccgcccgccgacgccgttccgtgcagctcacggagaagcgaatg
gacaaagtcggcaagtaccccaaggagctgcgcaagtgctgcgaggacggcatgcgggag
aaccccatgaggttctcgtgccagcgccggacccgtttcatctccctgggcgaggcgtgc
aagaaggtcttcctggactgctgcaactacatcacagagctgcggcggcagcacgcgcgg
gccagccacctgggcctggccaggagtaacctggatgaggacatcattgcagaagagaac
atcgtttcccgaagtgagttcccagagagctggctgtggaacgttgaggacttgaaagag
ccaccgaaaaatggaatctctacgaagctcatgaatatatttttgaaagactccatcacc
acgtgggagattctggctgtgagcatgtcggacaagaaagggatctgtgtggcagacccc
ttcgaggtcacagtaatgcaggacttcttcatcgacctgcggctaccctactctgttgtt
cgaaacgagcaggtggaaatccgagccgttctctacaattaccggcagaaccaagagctc
aaggtgagggtggaactactccacaatccagccttctgcagcctggccaccaccaagagg
cgtcaccagcagaccgtaaccatcccccccaagtcctcgttgtccgttccatatgtcatc
gtgccgctaaagaccggcctgcaggaagtggaagtcaaggctgctgtctaccatcatttc
atcagtgacggtgtcaggaagtccctgaaggtcgtgccggaaggaatcagaatgaacaaa
actgtggctgttcgcaccctggatccagaacgcctgggccgtgaaggagtgcagaaagag
gacatcccacctgcagacctcagtgaccaagtcccggacaccgagtctgagaccagaatt
ctcctgcaagggaccccagtggcccagatgacagaggatgccgtcgacgcggaacggctg
aagcacctcattgtgaccccctcgggctgcggggaacagaacatgatcggcatgacgccc
acggtcatcgctgtgcattacctggatgaaacggagcagtgggagaagttcggcctagag
aagcggcagggggccttggagctcatcaagaaggggtacacccagcagctggccttcaga
caacccagctctgcctttgcggccttcgtgaaacgggcacccagcacctggctgaccgcc
tacgtggtcaaggtcttctctctggctgtcaacctcatcgccatcgactcccaagtcctc
tgcggggctgttaaatggctgatcctggagaagcagaagcccgacggggtcttccaggag
gatgcgcccgtgatacaccaagaaatgattggtggattacggaacaacaacgagaaagac
atggccctcacggcctttgttctcatctcgctgcaggaggctaaagatatttgcgaggag
caggtcaacagcctgccaggcagcatcactaaagcaggagacttccttgaagccaactac
atgaacctacagagatcctacactgtggccattgctggctatgctctggcccagatgggc
aggctgaaggggcctcttcttaacaaatttctgaccacagccaaagataagaaccgctgg
gaggaccctggtaagcagctctacaacgtggaggccacatcctatgccctcttggcccta
ctgcagctaaaagactttgactttgtgcctcccgtcgtgcgttggctcaatgaacagaga
tactacggtggtggctatggctctacccaggccaccttcatggtgttccaagccttggct
caataccaaaaggacgcccctgaccaccaggaactgaaccttgatgtgtccctccaactg
cccagccgcagctccaagatcacccaccgtatccactgggaatctgccagcctcctgcga
tcagaagagaccaaggaaaatgagggtttcacagtcacagctgaaggaaaaggccaaggc
accttgtcggtggtgacaatgtaccatgctaaggccaaagatcaactcacctgtaataaa
ttcgacctcaaggtcaccataaaaccagcaccggaaacagaaaagaggcctcaggatgcc
aagaacactatgatccttgagatctgtaccaggtaccggggagaccaggatgccactatg
tctatattggacatatccatgatgactggctttgctccagacacagatgacctgaagcag
ctggccaatggtgttgacagatacatctccaagtatgagctggacaaagccttctccgat
aggaacaccctcatcatctacctggacaaggtctcacactctgaggatgactgtctagct
ttcaaagttcaccaatactttaatgtagagcttatccagcctggagcagtcaaggtctac
gcctattacaacctggaggaaagctgtacccggttctaccatccggaaaaggaggatgga
aagctgaacaagctctgccgtgatgaactgtgccgctgtgctgaggagaattgcttcata
caaaagtcggatgacaaggtcaccctggaagaacggctggacaaggcctgtgagccagga
gtggactatgtgtacaagacccgactggtcaaggttcagctgtccaatgactttgacgag
tacatcatggccattgagcagaccatcaagtcaggctcggatgaggtgcaggttggacag
cagcgcacgttcatcagccccatcaagtgcagagaagccctgaagctggaggagaagaaa
cactacctcatgtggggtctctcctccgatttctggggagagaagcccaacctcagctac
atcatcgggaaggacacttgggtggagcactggcccgaggaggacgaatgccaagacgaa
gagaaccagaaacaatgccaggacctcggcgccttcaccgagagcatggttgtctttggg
tgccccaactga |