KEGG   Homo sapiens (human): 7386
Entry
7386              CDS       T01001                                 
Symbol
UQCRFS1, MC3DN10, RIP1, RIS1, RISP, UQCR5
Name
(RefSeq) ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
  KO
K00411  ubiquinol-cytochrome c reductase iron-sulfur subunit [EC:7.1.1.8]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04148  Efferocytosis
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05415  Diabetic cardiomyopathy
Module
hsa_M00151  Cytochrome bc1 complex respiratory unit
hsa_M00152  Cytochrome bc1 complex
Network
nt06252  Mitochondrial ROS formation (cancer)
nt06461  Huntington disease
nt06463  Parkinson disease
nt06466  Pathways of neurodegeneration
nt06529  Thermogenesis
nt06535  Efferocytosis
  Element
N00990  Electron transfer in Complex III
N00991  Mutation-caused aberrant Htt to electron transfer in Complex III
N01046  Maneb to electron transfer in Complex III
N01395  Cadmium to electron transfer in complex III
N01691  mitochondrial complex - UCP1 in Thermogenesis
N01777  Efferocytosis-induced NAD production
Disease
H02086  Mitochondrial complex III deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    7386 (UQCRFS1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    7386 (UQCRFS1)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    7386 (UQCRFS1)
  09159 Environmental adaptation
   04714 Thermogenesis
    7386 (UQCRFS1)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    7386 (UQCRFS1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    7386 (UQCRFS1)
   05012 Parkinson disease
    7386 (UQCRFS1)
   05014 Amyotrophic lateral sclerosis
    7386 (UQCRFS1)
   05016 Huntington disease
    7386 (UQCRFS1)
   05020 Prion disease
    7386 (UQCRFS1)
   05022 Pathways of neurodegeneration - multiple diseases
    7386 (UQCRFS1)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    7386 (UQCRFS1)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    7386 (UQCRFS1)
Enzymes [BR:hsa01000]
 7. Translocases
  7.1  Catalysing the translocation of protons
   7.1.1  Linked to oxidoreductase reactions
    7.1.1.8  quinol---cytochrome-c reductase
     7386 (UQCRFS1)
SSDB
Motif
Pfam: UCR_TM Ubiq-Cytc-red_N Rieske TPK_B1_binding
Other DBs
NCBI-GeneID: 7386
NCBI-ProteinID: NP_005994
OMIM: 191327
HGNC: 12587
Ensembl: ENSG00000169021
UniProt: P47985
Structure
Position
19:complement(29205320..29213151)
AA seq 274 aa
MLSVASRSGPFAPVLSATSRGVAGALRPLVQATVPATPEQPVLDLKRPFLSRESLSGQAV
RRPLVASVGLNVPASVCYSHTDIKVPDFSEYRRLEVLDSTKSSRESSEARKGFSYLVTGV
TTVGVAYAAKNAVTQFVSSMSASADVLALAKIEIKLSDIPEGKNMAFKWRGKPLFVRHRT
QKEIEQEAAVELSQLRDPQHDLDRVKKPEWVILIGVCTHLGCVPIANAGDFGGYYCPCHG
SHYDASGRIRLGPAPLNLEVPTYEFTSDDMVIVG
NT seq 825 nt   +upstreamnt  +downstreamnt
atgttgtcggtagcatcccgctcaggcccgttcgcgcccgtcctgtcggccacgtcccgc
ggggtggcgggcgcgctgcggcccttggtgcaggccacggtgcccgccaccccggagcag
cctgtgttggacctgaagcggcccttcctcagccgggagtcgctgagcggccaggccgtg
cgccggcctttggtcgcctccgtgggcctcaatgtccctgcttctgtttgttattcccac
acagacatcaaggtgcctgacttctctgaataccgccgccttgaagttttagatagtacg
aagtcttcaagagaaagcagcgaggctaggaaaggtttctcctatttggtaactggagta
actactgtgggtgtcgcatatgctgccaagaatgccgtcacccagttcgtttccagcatg
agtgcttctgctgatgtgttggccctggcgaaaatcgaaatcaagttatccgatattcca
gaaggcaagaacatggctttcaaatggagaggcaaacccctgtttgtgcgtcatagaacc
cagaaggaaattgagcaggaagctgcagttgaattatcacagttgagggacccacagcat
gatctagatcgagtaaagaaacctgaatgggttatcctgataggtgtttgcactcatctt
ggctgtgtacccattgcaaatgcaggagattttggtggttattactgcccttgccatggg
tcacactatgatgcatctggcaggatcagattgggtcctgctcctctcaaccttgaagtc
cccacgtatgagttcaccagtgacgatatggtgattgttggttaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (16)   
   KEGG PATHWAY (14)   
   KEGG MODULE (2)   
Network (12)   
   KEGG NETWORK (12)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (12)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (19)   
   RefSeq(nuc) (1)   
   GenBank (9)   
   EMBL (9)   
3D Structure (3)   
   PDB (3)   
Protein domain (4)   
   Pfam (4)   
All databases (86)   

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