| Entry |
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| Symbol |
CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP-3, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, WHIMS, WHIMS1
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| Name |
(RefSeq) C-X-C motif chemokine receptor 4
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| KO |
| K04189 | C-X-C chemokine receptor type 4 |
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| Organism |
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| Pathway |
| hsa03260 | Virion - Human immunodeficiency virus |
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa04061 | Viral protein interaction with cytokine and cytokine receptor |
| hsa04670 | Leukocyte transendothelial migration |
| hsa04672 | Intestinal immune network for IgA production |
| hsa04810 | Regulation of actin cytoskeleton |
| hsa05163 | Human cytomegalovirus infection |
| hsa05170 | Human immunodeficiency virus 1 infection |
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| Network |
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| Element |
| N00401 | CXCR4-GNAQ-PLCB/G-calcineurin signaling pathway |
| N00405 | CXCR4-GNA12/13-Rho signaling pathway |
| N00413 | CXCR4-GNB/G-PLCB-PKC signaling pathway |
| N00430 | CXCR4-GNAI-PI3K-BAD signaling pathway |
| N00431 | HIV gp120 to CXCR4-GNAI-PI3K-BAD signaling pathway |
| N00432 | HIV gp120 to CXCR4-GNAQ-PLCB/G-calcineurin |
| N00433 | CXCR4-GNB/G-RAC signaling pathway |
| N00434 | HIV gp120 to CXCR4-GNB/G-RAC signaling pathway |
| N00546 | CXCL12-CXCR4-PKC-ERK signaling pathaway |
| N01640 | GPCR-PLCB-ITPR signaling pathway |
| N01765 | CXCR4-GNAQ-PLCB/G signaling pathway |
| N01767 | CXCR4-GNAI-Src signaling pathway |
| N01768 | CXCR4-GNA12/13 signaling pathway |
| N01771 | CXCR4-GNB/G signaling pathway |
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| Disease |
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| Drug target |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09120 Genetic Information Processing
09125 Information processing in viruses
03250 Viral life cycle - HIV-1
7852 (CXCR4)
03260 Virion - Human immunodeficiency virus
7852 (CXCR4)
09130 Environmental Information Processing
09132 Signal transduction
04020 Calcium signaling pathway
7852 (CXCR4)
09133 Signaling molecules and interaction
04060 Cytokine-cytokine receptor interaction
7852 (CXCR4)
04061 Viral protein interaction with cytokine and cytokine receptor
7852 (CXCR4)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
7852 (CXCR4)
09142 Cell motility
04810 Regulation of actin cytoskeleton
7852 (CXCR4)
09150 Organismal Systems
09151 Immune system
04670 Leukocyte transendothelial migration
7852 (CXCR4)
04672 Intestinal immune network for IgA production
7852 (CXCR4)
04062 Chemokine signaling pathway
7852 (CXCR4)
09158 Development and regeneration
04360 Axon guidance
7852 (CXCR4)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
7852 (CXCR4)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
7852 (CXCR4)
05163 Human cytomegalovirus infection
7852 (CXCR4)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04030 G protein-coupled receptors [BR:hsa04030]
7852 (CXCR4)
04050 Cytokine receptors [BR:hsa04050]
7852 (CXCR4)
04090 CD molecules [BR:hsa04090]
7852 (CXCR4)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
Chemokine
CXC Chemokine
7852 (CXCR4)
Cytokine receptors [BR:hsa04050]
Chemokine receptors
CXC Chemokine
7852 (CXCR4)
CD molecules [BR:hsa04090]
Proteins
7852 (CXCR4)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| Position |
2:complement(136114349..136118149)
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| AA seq |
352 aa
MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVI
LVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNL
YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEA
DDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKT
TVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPI
LYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS |
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| NT seq |
1059 nt +upstreamnt +downstreamnt
atggaggggatcagtatatacacttcagataactacaccgaggaaatgggctcaggggac
tatgactccatgaaggaaccctgtttccgtgaagaaaatgctaatttcaataaaatcttc
ctgcccaccatctactccatcatcttcttaactggcattgtgggcaatggattggtcatc
ctggtcatgggttaccagaagaaactgagaagcatgacggacaagtacaggctgcacctg
tcagtggccgacctcctctttgtcatcacgcttcccttctgggcagttgatgccgtggca
aactggtactttgggaacttcctatgcaaggcagtccatgtcatctacacagtcaacctc
tacagcagtgtcctcatcctggccttcatcagtctggaccgctacctggccatcgtccac
gccaccaacagtcagaggccaaggaagctgttggctgaaaaggtggtctatgttggcgtc
tggatccctgccctcctgctgactattcccgacttcatctttgccaacgtcagtgaggca
gatgacagatatatctgtgaccgcttctaccccaatgacttgtgggtggttgtgttccag
tttcagcacatcatggttggccttatcctgcctggtattgtcatcctgtcctgctattgc
attatcatctccaagctgtcacactccaagggccaccagaagcgcaaggccctcaagacc
acagtcatcctcatcctggctttcttcgcctgttggctgccttactacattgggatcagc
atcgactccttcatcctcctggaaatcatcaagcaagggtgtgagtttgagaacactgtg
cacaagtggatttccatcaccgaggccctagctttcttccactgttgtctgaaccccatc
ctctatgctttccttggagccaaatttaaaacctctgcccagcacgcactcacctctgtg
agcagagggtccagcctcaagatcctctccaaaggaaagcgaggtggacattcatctgtt
tccactgagtctgagtcttcaagttttcactccagctaa |
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