KEGG   Homo sapiens (human): 790
Entry
790               CDS       T01001                                 
Symbol
CAD, CDG1Z, DEE50, EIEE50, GATD4
Name
(RefSeq) carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
  KO
K11540  carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase [EC:6.3.5.5 2.1.3.2 3.5.2.3]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00240  Pyrimidine metabolism
hsa00250  Alanine, aspartate and glutamate metabolism
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
Module
hsa_M00051  De novo pyrimidine biosynthesis, glutamine (+ PRPP) => UMP
Disease
H00606  Early infantile epileptic encephalopathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    790 (CAD)
  09105 Amino acid metabolism
   00250 Alanine, aspartate and glutamate metabolism
    790 (CAD)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    790 (CAD)
Enzymes [BR:hsa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.3  Carboxy- and carbamoyltransferases
    2.1.3.2  aspartate carbamoyltransferase
     790 (CAD)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.3  dihydroorotase
     790 (CAD)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.5  Carbon-nitrogen ligases with glutamine as amido-N-donor
    6.3.5.5  carbamoyl-phosphate synthase (glutamine-hydrolysing)
     790 (CAD)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C26: gamma-glutamyl hydrolase family
   790 (CAD)
 Metallo peptidases
  Family M38: beta-aspartyl dipeptidase family
   790 (CAD)
SSDB
Motif
Pfam: CPSase_L_D2 GATase CPSase_sm_chain OTCace_N OTCace CPSase_L_D3 ATP-grasp Dala_Dala_lig_C MGS ATPgrasp_Ter Amidohydro_1 ATP-grasp_3 Peptidase_C26 GARS_A
Other DBs
NCBI-GeneID: 790
NCBI-ProteinID: NP_004332
OMIM: 114010
HGNC: 1424
Ensembl: ENSG00000084774
UniProt: P27708
Structure
Position
2:27217369..27243943
AA seq 2225 aa
MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNY
GIPPDEMDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQGVD
TRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPRILA
LDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLSRVL
SEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGFAVE
TDSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETVKEA
TAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAI
KALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQT
ALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLEQ
AQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSLKGWKEI
EYEVVRDAYGNCVTVCNMENLDPLGIHTGESIVVAPSQTLNDREYQLLRQTAIKVTQHLG
IVGECNVQYALNPESEQYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRN
SVTGGTAAFEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKAL
RMVDENCVGFDHTVKPVSDMELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRM
KRIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAV
KQIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQ
QLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLP
NNMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQT
VGYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAV
ASDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFN
LQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVG
VKVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIG
SYKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSI
LEQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEAL
GQIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMV
CAMPNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSENAGTLGTVAGSAAGLKLYLN
ETFSELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKEE
ILLIKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVI
DCFASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIF
HLPPQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVL
VPPGYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRGIPGLPDGRFHLPPRIHRASD
PGLPAEEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQASPQNLGTPGLLHPQTSPLLHS
LVGQHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMASMFYEVSTRTSSSF
AAAMARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVVVLRHPQPGAVELAAKHCRR
PVINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRTVHSLACLLTQYRVS
LRYVAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYMTRIQKERFGSTQEYEA
CFGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQAENGMYIRMALLAT
VLGRF
NT seq 6678 nt   +upstreamnt  +downstreamnt
atggcggccctagtgttggaggacgggtcggtcctgcggggccagccctttggggccgcc
gtgtcgactgccggggaagtggtgtttcaaaccggcatggtcggctaccccgaggccctc
actgatccctcctacaaggcacagatcttagtgctcacctatcctctgatcggcaactat
ggcatccccccagatgaaatggatgagttcggtctctgcaagtggtttgaatcctcgggc
atccacgtagcagcactggtagtgggagagtgctgtcctactcccagccactggagtgcc
acccgcaccctgcatgagtggctgcagcagcatggcatccctggcttgcaaggagtagac
actcgggagctgaccaagaagttgcgggaacaggggtctctgctggggaagctggtccag
aatggaacagaaccttcatccctgccattcttggaccccaatgcccgccccctggtacca
gaggtctccattaagactccacgggtattcaatacagggggtgcccctcggatccttgct
ttggactgtggcctcaagtataatcagatccgatgcctctgccagcgtggggctgaggtc
actgtggtaccctgggaccatgcactagacagccaagagtatgagggtctcttcttaagt
aatgggcctggtgaccctgcctcctatcccagtgtcgtatccacactgagccgtgtttta
tctgagcctaatccccgacctgtctttgggatctgcctgggacaccagctattggcctta
gccattggggccaagacttacaagatgagatatgggaaccgaggccataaccagccctgc
ttgttggtgggctctgggcgctgctttctgacatcccagaaccatgggtttgctgtggag
acagactcactgccagcagactgggctcctctcttcaccaacgccaatgatggttccaat
gaaggcattgtgcacaacagcttgcctttcttcagtgtccagtttcacccagagcaccaa
gctggcccttcagatatggaactgcttttcgatatctttctggaaactgtgaaagaggcc
acagctgggaaccctgggggccagacagttagagagcggctgactgagcgcctctgtccc
cctgggattcccactcccggctctggacttccaccaccacgaaaggttctgatcctgggc
tcagggggcctctccattggccaagctggagaatttgactactcgggctctcaggcaatt
aaggccctgaaggaggaaaacatccagacgttgctgatcaaccccaatattgccacagtg
cagacctcccaggggctggccgacaaggtctattttcttcccataacacctcattatgta
acccaggtgatacgtaatgaacgccccgatggtgtgttactgacttttgggggccagact
gctctgaactgtggtgtggagctgaccaaggccggggtgctggctcggtatggggtccgg
gtcctgggcacaccagtggagaccattgagctgaccgaggatcgacgggcctttgctgcc
agaatggcagagatcggagagcatgtggccccgagcgaggcagcaaattctcttgaacag
gcccaggcagccgctgaacggctggggtaccctgtgctagtgcgtgcagcctttgccctg
ggtggcctgggctctggctttgcctctaacagggaggagctctctgctctcgtggcccca
gcttttgcccataccagccaagtgctagtagacaagtctctgaagggatggaaggagatt
gagtacgaggtggtgagagacgcctatggcaactgtgtcacggtgtgtaacatggagaac
ttggacccactgggcatccacactggtgagtccatagtggtggcccctagccagacactg
aatgacagggagtatcagctcctgaggcagacagctatcaaggtgacccagcacctggga
attgttggggagtgcaatgtgcagtatgccttgaaccctgagtctgagcagtattacatc
attgaagtgaatgccaggctctctcgcagctctgccctggccagtaaggccacaggttat
ccactggcttatgtggcagccaagctagcattgggcatccctttgcctgagctcaggaac
tctgtgacagggggtacagcagcctttgaacccagcgtggattattgtgtggtgaagatt
cctcgatgggaccttagcaagttcctgcgagtcagcacaaagattgggagctgcatgaag
agcgttggtgaagtcatgggcattgggcgttcatttgaggaggccttccagaaggccctg
cgcatggtggatgagaactgtgtgggctttgatcacacagtgaaaccagtcagcgatatg
gagttggagactccaacagataagcggatttttgtggtggcagctgctttgtgggctggt
tattcagtggaccgcctgtatgagctcacacgcatcgaccgctggttcctgcaccgaatg
aagcgtatcatcgcacatgcccagctgctagaacaacaccgtggacagcctttgccgcca
gacctgctgcaacaggccaagtgtcttggcttctcagacaaacagattgcccttgcagtt
ctgagcacagagctggctgttcgcaagctgcgtcaggaactggggatctgtccagcagtg
aaacagattgacacagttgcagctgagtggccagcccagacaaattacctatacctaacg
tattggggcaccacccatgacctcacctttcgaacacctcatgtcctagtccttggctct
ggcgtctaccgtattggctctagcgttgaatttgactggtgtgctgtaggctgcatccag
cagctccgaaagatgggatataagaccatcatggtgaactataacccagagacagtcagc
accgactatgacatgtgtgatcgactctactttgatgagatctcttttgaggtggtgatg
gacatctatgagctcgagaaccctgaaggtgtgatcctatccatgggtggacagctgccc
aacaacatggccatggcgttgcatcggcagcagtgccgggtgctgggcacctcccctgaa
gccattgactcggctgagaaccgtttcaagttttcccggctccttgacaccattggtatc
agccagcctcagtggagggagctcagtgacctcgagtctgctcgccaattctgccagacc
gtggggtacccctgtgtggtgcgcccctcctatgtgctgagcggtgctgctatgaatgtg
gcctacacggatggagacctggagcgcttcctgagcagcgcagcagccgtctccaaagag
catcccgtggtcatctccaagttcatccaggaggctaaggagattgacgtggatgccgtg
gcctctgatggtgtggtggcagccatcgccatctctgagcatgtggagaatgcaggtgtg
cattcaggtgatgcgacgctggtgacccccccacaagatatcactgccaaaaccctggag
cggatcaaagccattgtgcatgctgtgggccaggagctacaggtcacaggacccttcaat
ctgcagctcattgccaaggatgaccagctgaaagttattgaatgcaacgtacgtgtctct
cgctccttccccttcgtttccaagacactgggtgtggacctagtagccttggccacgcgg
gtcatcatgggggaagaagtggaacctgtggggctaatgactggttctggagtcgtggga
gtaaaggtgcctcagttctccttctcccgcttggcgggtgctgacgtggtgttgggtgtg
gaaatgaccagtactggggaggtggccggctttggggagagccgctgtgaggcatacctc
aaggccatgctaagcactggctttaagatccccaagaagaatatcctgctgaccattggc
agctataagaacaaaagcgagctgctcccaactgtgcggctactggagagcctgggctac
agcctctatgccagtctcggcacagctgacttctacactgagcatggcgtcaaggtaaca
gctgtggactggcactttgaggaggctgtggatggtgagtgcccaccacagcggagcatc
ctggagcagctagctgagaaaaactttgagctggtgattaacctgtcaatgcgtggagct
gggggccggcgtctctcttcctttgtcaccaagggctaccgcacccgacgcttggccgct
gacttctccgtgcccctaatcatcgatatcaagtgcaccaaactctttgtggaggcccta
ggccagatcgggccagcccctcctttgaaggtgcatgttgactgtatgacctcccaaaag
cttgtgcgactgccgggattgattgatgtccatgtgcacctgcgggaaccaggtgggaca
cataaggaggactttgcttcaggcacagccgctgccctggctgggggtatcaccatggtg
tgtgccatgcctaatacccggccccccatcattgacgcccctgctctggccctggcccag
aagctggcagaggctggcgcccggtgcgactttgcgctattccttggggcctcgtctgaa
aatgcaggaaccttgggcaccgtggccgggtctgcagccgggctgaagctttacctcaat
gagaccttctctgagctgcggctggacagcgtggtccagtggatggagcatttcgagaca
tggccctcccacctccccattgtggctcacgcagagcagcaaaccgtggctgctgtcctc
atggtggctcagctcactcagcgctcagtgcacatatgtcacgtggcacggaaggaggag
atcctgctaattaaagctgcaaaggcacggggcttgccagtgacctgcgaggtggctccc
caccacctgttcctaagccatgatgacctggagcgcctggggcctgggaagggggaggtc
cggcctgagcttggctcccgccaggatgtggaagccctgtgggagaacatggctgtcatc
gactgctttgcctcagaccatgctccccataccttggaggagaagtgtgggtccaggccc
ccacctgggttcccagggttagagaccatgctgccactactcctgacggctgtaagcgag
ggccggctcagcctggacgacctgctgcagcgattgcaccacaatcctcggcgcatcttt
cacctgcccccgcaggaggacacctatgtggaggtggatctggagcatgagtggacaatt
cccagccacatgcccttctccaaggcccactggacaccttttgaagggcagaaagtgaag
ggcaccgtccgccgtgtggtcctgcgaggggaggttgcctatatcgatgggcaggttctg
gtacccccgggctatggacaggatgtacggaagtggccacagggggctgttcctcagctc
ccaccctcagcccctgccactagtgagatgaccacgacacctgaaagaccccgccgtggc
atcccagggcttcctgatggccgcttccatctgccgccccgaatccatcgagcctccgac
ccaggtttgccagctgaggagccaaaggagaagtcctctcggaaggtagccgagccagag
ctgatgggaacccctgatggcacctgctaccctccaccaccagtaccgagacaggcatct
ccccagaacctggggacccctggcttgctgcacccccagacctcacccctgctgcactca
ttagtgggccaacatatcctgtccgtccagcagttcaccaaggatcagatgtctcacctg
ttcaatgtggcacacacactgcgtatgatggtgcagaaggagcggagcctcgacatcctg
aaggggaaggtcatggcctccatgttctatgaagtgagcacacggaccagcagctccttt
gcagcagccatggcccggctgggaggtgctgtgctcagcttctcggaagccacatcgtcc
gtccagaagggcgaatccctggctgactccgtgcagaccatgagctgctatgccgacgtc
gtcgtgctccggcacccccagcctggagcagtggagctggccgccaagcactgccggagg
ccagtgatcaatgctggggatggggtcggagagcaccccacccaggccctgctggacatc
ttcaccatccgtgaggagctgggaactgtcaatggcatgacgatcacgatggtgggtgac
ctgaagcacggacgcacagtacattccctggcctgcctgctcacccagtatcgtgtcagc
ctgcgctacgtggcacctcccagcctgcgcatgccacccactgtgcgggccttcgtggcc
tcccgcggcaccaagcaggaggaattcgagagcattgaggaggcgctgcctgacactgat
gtgctctacatgactcgaatccagaaggaacgatttggctctacccaggagtacgaagct
tgctttggtcagttcatcctcactccccacatcatgacccgggccaagaagaagatggtg
gtgatgcacccgatgccccgtgtcaacgagataagcgtggaagtggactcggatccccgc
gcagcctacttccgccaggctgagaacggcatgtacatccgcatggctctgttagccacc
gtgctgggccgtttctag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (14)   
   KEGG COMPOUND (14)   
Chemical reaction (10)   
   KEGG ENZYME (3)   
   KEGG REACTION (7)   
Genome (1)   
   KEGG GENOME (1)   
Gene (40)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (27)   
   OC (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (26)   
   RefSeq(nuc) (6)   
   GenBank (10)   
   EMBL (10)   
3D Structure (50)   
   PDB (50)   
Protein domain (14)   
   Pfam (14)   
All databases (174)   

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