KEGG   Homo sapiens (human): 7915
Entry
7915              CDS       T01001                                 
Symbol
ALDH5A1, SSADH, SSDH
Name
(RefSeq) aldehyde dehydrogenase 5 family member A1
  KO
K00139  succinate-semialdehyde dehydrogenase [EC:1.2.1.24]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00250  Alanine, aspartate and glutamate metabolism
hsa00650  Butanoate metabolism
hsa01100  Metabolic pathways
Module
hsa_M00027  GABA (gamma-Aminobutyrate) shunt
Disease
H00835  Succinic semialdehyde dehydrogenase deficiency
Drug target
Valproic acid (DG00849): D00304<US> D00399<US> D00710<JP/US> D08667
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00650 Butanoate metabolism
    7915 (ALDH5A1)
  09105 Amino acid metabolism
   00250 Alanine, aspartate and glutamate metabolism
    7915 (ALDH5A1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.24  succinate-semialdehyde dehydrogenase (NAD+)
     7915 (ALDH5A1)
SSDB
Motif
Pfam: Aldedh
Other DBs
NCBI-GeneID: 7915
NCBI-ProteinID: NP_001071
OMIM: 610045
HGNC: 408
Ensembl: ENSG00000112294
UniProt: P51649 X5DQN2
Structure
Position
6:24494969..24537207
AA seq 535 aa
MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLR
TDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKER
SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIH
TPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALAL
AELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSV
KRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAF
AEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFF
EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWR
VAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL
NT seq 1608 nt   +upstreamnt  +downstreamnt
atggcgacctgcatttggctgcggagctgtggggcccggcgcctcgggtcgacgtttcca
ggctgccgcctccgcccccgcgccggcggcctggtccctgcctccgggcctgcgcccggc
ccggcccagctccgctgctacgctgggcgcctggcgggcctctctgcggcgctgctgcgc
accgacagcttcgtgggcggccgctggctcccggccgccgccaccttccccgtgcaagac
ccggccagcggcgccgctctgggcatggtagccgactgcggggtgcgagaggcccgcgcc
gccgtgcgcgctgcctacgaggctttctgccgctggagggaggtctccgccaaggagagg
agttcattacttcggaagtggtacaatttaatgatacaaaataaggatgaccttgccaga
ataatcacagctgaaagtggaaagccactgaaggaggcacatggagaaattctctattcc
gcctttttcctagagtggttctctgaggaagcccgccgtgtttacggagacattatccac
accccggcaaaggacaggcgggccctggtcctcaagcagcccataggcgtggctgcagtc
atcaccccgtggaatttccccagtgccatgatcacccggaaggtgggggccgccctggca
gccggctgtactgtcgtggtgaagcctgccgaagacacgcccttctccgccctggccctg
gctgagcttgcaagccaggctgggattccttcaggtgtatacaatgttattccctgttct
cgaaagaatgccaaggaagtaggggaggcaatttgtactgatcctctggtgtccaaaatt
tcctttactggttcaacaactacaggaaagatcctgttgcaccacgcagcaaactctgtg
aaaagggtctctatggagctgggcggccttgctccatttatagtatttgacagtgccaac
gtggaccaggctgtagcaggggccatggcatctaaatttaggaacactggacagacttgt
gtttgctcaaaccaattcttggtgcaaaggggcatccatgatgcctttgtaaaagcattc
gccgaggccatgaagaagaacctgcgcgtaggtaatggatttgaggaaggaactactcag
ggcccattaattaatgaaaaagcggtagaaaaggtggagaaacaggtgaatgatgccgtt
tctaaaggtgccaccgttgtgacaggtggaaaacgacaccaacttggaaaaaatttcttt
gagcctaccctgctgtgcaatgtcacccaggacatgctgtgcactcatgaagagactttc
gggcctctggcaccagttatcaagttcgatacagaggaggaggctatagcaatcgctaac
gcagctgatgttgggttagcaggttatttttactctcaagacccagcccagatctggaga
gtggcagagcagctggaagtgggcatggttggcgtcaacgaaggattaatttcctctgtg
gagtgcccttttggtggagtgaagcagtccggccttgggcgagaggggtccaagtatggc
attgatgagtatctggaactcaagtatgtgtgttacgggggcttgtag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (4)   
   KEGG DRUG (4)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (33)   
   RefSeq(nuc) (3)   
   GenBank (15)   
   EMBL (15)   
3D Structure (5)   
   PDB (5)   
Protein domain (1)   
   Pfam (1)   
All databases (78)   

Download RDF
DBGET integrated database retrieval system