KEGG   Homo sapiens (human): 84451
Entry
84451             CDS       T01001                                 
Symbol
MAP3K21, MLK4, dJ862P8.3
Name
(RefSeq) mitogen-activated protein kinase kinase kinase 21
  KO
K17534  mitogen-activated protein kinase kinase kinase MLK4 [EC:2.7.11.25]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
Network
nt06526  MAPK signaling
  Element
N01594  MLK-JNK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    84451 (MAP3K21)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    84451 (MAP3K21)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     84451 (MAP3K21)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  MLK family
   84451 (MAP3K21)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase SH3_9 SH3_1 SH3_2 ABC1 Pkinase_fungal RNase_Y_N
Other DBs
NCBI-GeneID: 84451
NCBI-ProteinID: NP_115811
OMIM: 614793
HGNC: 29798
Ensembl: ENSG00000143674
UniProt: Q5TCX8
Structure
Position
1:233327724..233385148
AA seq 1036 aa
MALRGAAGATDTPVSSAGGAPGGSASSSSTSSGGSASAGAGLWAALYDYEARGEDELSLR
RGQLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANYVAPCRPAASPAPPPSRPSSPVHVA
FERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRH
PNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNW
AVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTT
KMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNK
LTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSMQDD
WKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAEREIDVLERELN
ILIFQLNQEKPKVKKRKGKFKRSRLKLKDGHRISLPSDFQHKITVQASPNLDKRRSLNSS
SSSPPSSPTMMPRLRAIQLTSDESNKTWGRNTVFRQEEFEDVKRNFKKKGCTWGPNSIQM
KDRTDCKERIRPLSDGNSPWSTILIKNQKTMPLASLFVDQPGSCEEPKLSPDGLEHRKPK
QIKLPSQAYIDLPLGKDAQRENPAEAESWEEAASANAATVSIEMTPTNSLSRSPQRKKTE
SALYGCTVLLASVALGLDLRELHKAQAAEEPLPKEEKKKREGIFQRASKSRRSASPPTSL
PSTCGEASSPPSLPLSSALGILSTPSFSTKCLLQMDSEDPLVDSAPVTCDSEMLTPDFCP
TAPGSGREPALMPRLDTDCSVSRNLPSSFLQQTCGNVPYCASSKHRPSHHRRTMSDGNPT
PTGATIISATGASALPLCPSPAPHSHLPREVSPKKHSTVHIVPQRRPASLRSRSDLPQAY
PQTAVSQLAQTACVVGRPGPHPTQFLAAKERTKSHVPSLLDADVEGQSRDYTVPLCRMRS
KTSRPSIYELEKEFLS
NT seq 3111 nt   +upstreamnt  +downstreamnt
atggctttgcggggcgccgcgggagcgaccgacaccccggtgtcctcggccgggggagcc
cccggcggctcagcgtcctcgtcgtccacctcctcgggcggctcggcctcggcgggcgcg
gggctgtgggccgcgctctatgactacgaggctcgcggcgaggacgagctgagcctgcgg
cgcggccagctggtggaggtgctgtcgcaggacgccgccgtgtcgggcgacgagggctgg
tgggcaggccaggtgcagcggcgcctcggcatcttccccgccaactacgtggctccctgc
cgcccggccgccagccccgcgccgccgccctcgcggcccagctccccggtacacgtcgcc
ttcgagcggctggagctgaaggagctcatcggcgctgggggcttcgggcaggtgtaccgc
gccacctggcagggccaggaggtggccgtgaaggcggcgcgccaggacccggagcaggac
gcggcggcggctgccgagagcgtgcggcgcgaggctcggctcttcgccatgctgcggcac
cccaacatcatcgagctgcgcggcgtgtgcctgcagcagccgcacctctgcctggtgctg
gagttcgcccgcggcggagcgctcaaccgagcgctggccgctgccaacgccgccccggac
ccgcgcgcgcccggcccccgccgcgcgcgccgcatccctccgcacgtgctggtcaactgg
gccgtgcagatagcgcggggcatgctctacctgcatgaggaggccttcgtgcccatcctg
caccgggacctcaagtccagcaacattttgctacttgagaagatagaacatgatgacatc
tgcaataaaactttgaagattacagattttgggttggcgagggaatggcacaggaccacc
aaaatgagcacagcaggcacctatgcctggatggcccccgaagtgatcaagtcttccttg
ttttctaagggaagcgacatctggagctatggagtgctgctgtgggaactgctcaccgga
gaagtcccctatcggggcattgatggcctcgccgtggcttatggggtagcagtcaataaa
ctcactttgcccattccatccacctgccctgagccgtttgccaagctcatgaaagaatgc
tggcaacaagaccctcatattcgtccatcgtttgccttaattctcgaacagttgactgct
attgaaggggcagtgatgactgagatgcctcaagaatcttttcattccatgcaagatgac
tggaaactagaaattcaacaaatgtttgatgagttgagaacaaaggaaaaggagctgcga
tcccgggaagaggagctgactcgggcggctctgcagcagaagtctcaggaggagctgcta
aagcggcgtgagcagcagctggcagagcgcgagatcgacgtgctggagcgggaacttaac
attctgatattccagctaaaccaggagaagcccaaggtaaagaagaggaagggcaagttt
aagagaagtcgtttaaagctcaaagatggacatcgaatcagtttaccttcagatttccag
cacaagataaccgtgcaggcctctcccaacttggacaaacggcggagcctgaacagcagc
agttccagtcccccgagcagccccacaatgatgccccgactccgagccatacagttgact
tcagatgaaagcaataaaacttggggaaggaacacagtctttcgacaagaagaatttgag
gatgtaaaaaggaattttaagaaaaaaggttgtacctggggaccaaattccattcaaatg
aaagatagaacagattgcaaagaaaggataagacctctctccgatggcaacagtccttgg
tcaactatcttaataaaaaatcagaaaaccatgcccttggcttcattgtttgtggaccag
ccagggtcctgtgaagagccaaaactttcccctgatggattagaacacagaaaaccaaaa
caaataaaattgcctagtcaggcctacattgatctacctcttgggaaagatgctcagaga
gagaatcctgcagaagctgaaagctgggaggaggcagcctctgcgaatgctgccacagtc
tccattgagatgactcctacgaatagtctgagtagatccccccagagaaagaaaacggag
tcagctctgtatgggtgcaccgtccttctggcatcggtggctctgggactggacctcaga
gagcttcataaagcacaggctgctgaagaaccgttgcccaaggaagagaagaagaaacga
gagggaatcttccagcgggcttccaagtcccgcagaagcgccagtcctcccacaagcctg
ccatccacctgtggggaggccagcagcccaccctccctgccactgtcaagtgccctgggc
atcctctccacaccttctttctccacaaagtgcctgctgcagatggacagtgaagatcca
ctggtggacagtgcacctgtcacttgtgactctgagatgctcactccggatttttgtccc
actgccccaggaagtggtcgtgagccagccctcatgccaagacttgacactgattgtagt
gtatcaagaaacttgccgtcttccttcctacagcagacatgtgggaatgtaccttactgt
gcttcttcaaaacatagaccgtcacatcacagacggaccatgtctgatggaaatccgacc
ccaactggtgcaactattatctcagccactggagcctctgcactgccactctgcccctca
cctgctcctcacagtcatctgccaagggaggtctcacccaagaagcacagcactgtccac
atcgtgcctcagcgtcgccctgcctccctgagaagccgctcagatctgcctcaggcttac
ccacagacagcagtgtctcagctggcacagactgcctgtgtagtgggtcgcccaggacca
catcccacccaattcctcgctgccaaggagagaactaaatcccatgtgccttcattactg
gatgctgacgtggaaggtcagagcagggactacactgtgccactgtgcagaatgaggagc
aaaaccagccggccatctatatatgaactggagaaagaattcctgtcttaa

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (31)   
   KEGG ORTHOLOGY (1)   
   RefGene (25)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (13)   
   RefSeq(nuc) (1)   
   GenBank (6)   
   EMBL (6)   
3D Structure (1)   
   PDB (1)   
Protein domain (8)   
   Pfam (8)   
All databases (65)   

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