Entry |
|
Symbol |
CASR, CAR, EIG8, FHH, FIH, GPRC2A, HHC, HHC1, HYPOC1, NSHPT, PCAR1, hCasR
|
Name |
(RefSeq) calcium sensing receptor
|
KO |
K04612 | calcium-sensing receptor |
|
Organism |
|
Pathway |
hsa04621 | NOD-like receptor signaling pathway |
hsa04928 | Parathyroid hormone synthesis, secretion and action |
|
Network |
|
Element |
N00291 | CaSR-PTH signaling pathway |
|
Disease |
H00245 | Calcium sensing receptor (CASR) related disease |
H00246 | Primary hyperparathyroidism |
H00808 | Idiopathic generalized epilepsies |
H02026 | Familial hypocalciuric hypercalcemia |
H02030 | Neonatal hyperparathyroidism |
|
Drug target |
Ronacaleret hydrochloride: | D08991 |
Tecalcet hydrochloride: | D06020 |
Upacicalcet sodium hydrate: | D11564<JP> |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
09150 Organismal Systems
09151 Immune system
04621 NOD-like receptor signaling pathway
846 (CASR)
09152 Endocrine system
04928 Parathyroid hormone synthesis, secretion and action
846 (CASR)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04030 G protein-coupled receptors [BR:hsa04030]
846 (CASR)
G protein-coupled receptors [BR:hsa04030]
Metabotropic glutamate receptor family
Calcium-sensing
846 (CASR)
|
SSDB |
|
Motif |
|
Other DBs |
|
Structure |
|
Position |
3:122183668..122291629
|
AA seq |
1078 aa
MAFYSCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVEC
IRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKI
DSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQF
KSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFS
ELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWA
SSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHL
QEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNV
YLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFD
ECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFS
NCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIA
KEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLC
CFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWG
LNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYT
CLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIA
ILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSS
SLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQP
RCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHEPLLPLQCGE
TDLDLTVQETGLQGPVGGDQRPEVEDPEELSPALVVSSSQSFVISGGGSTVTENVVNS |
NT seq |
3237 nt +upstreamnt +downstreamnt
atggcattttatagctgctgctgggtcctcttggcactcacctggcacacctctgcctac
gggccagaccagcgagcccaaaagaagggggacattatccttggggggctctttcctatt
cattttggagtagcagctaaagatcaagatctcaaatcaaggccggagtctgtggaatgt
atcaggtataatttccgtgggtttcgctggttacaggctatgatatttgccatagaggag
ataaacagcagcccagcccttcttcccaacttgacgctgggatacaggatatttgacact
tgcaacaccgtttctaaggccttggaagccaccctgagttttgttgctcaaaacaaaatt
gattctttgaaccttgatgagttctgcaactgctcagagcacattccctctacgattgct
gtggtgggagcaactggctcaggcgtctccacggcagtggcaaatctgctggggctcttc
tacattccccaggtcagttatgcctcctccagcagactcctcagcaacaagaatcaattc
aagtctttcctccgaaccatccccaatgatgagcaccaggccactgccatggcagacatc
atcgagtatttccgctggaactgggtgggcacaattgcagctgatgacgactatgggcgg
ccggggattgagaaattccgagaggaagctgaggaaagggatatctgcatcgacttcagt
gaactcatctcccagtactctgatgaggaagagatccagcatgtggtagaggtgattcaa
aattccacggccaaagtcatcgtggttttctccagtggcccagatcttgagcccctcatc
aaggagattgtccggcgcaatatcacgggcaagatctggctggccagcgaggcctgggcc
agctcctccctgatcgccatgcctcagtacttccacgtggttggcggcaccattggattc
gctctgaaggctgggcagatcccaggcttccgggaattcctgaagaaggtccatcccagg
aagtctgtccacaatggttttgccaaggagttttgggaagaaacatttaactgccacctc
caagaaggtgcaaaaggacctttacctgtggacacctttctgagaggtcacgaagaaagt
ggcgacaggtttagcaacagctcgacagccttccgacccctctgtacaggggatgagaac
atcagcagtgtcgagaccccttacatagattacacgcatttacggatatcctacaatgtg
tacttagcagtctactccattgcccacgccttgcaagatatatatacctgcttacctggg
agagggctcttcaccaatggctcctgtgcagacatcaagaaagttgaggcgtggcaggtc
ctgaagcacctacggcatctaaactttacaaacaatatgggggagcaggtgacctttgat
gagtgtggtgacctggtggggaactattccatcatcaactggcacctctccccagaggat
ggctccatcgtgtttaaggaagtcgggtattacaacgtctatgccaagaagggagaaaga
ctcttcatcaacgaggagaaaatcctgtggagtgggttctccagggaggtgcccttctcc
aactgcagccgagactgcctggcagggaccaggaaagggatcattgagggggagcccacc
tgctgctttgagtgtgtggagtgtcctgatggggagtatagtgatgagacagatgccagt
gcctgtaacaagtgcccagatgacttctggtccaatgagaaccacacctcctgcattgcc
aaggagatcgagtttctgtcgtggacggagccctttgggatcgcactcaccctctttgcc
gtgctgggcattttcctgacagcctttgtgctgggtgtgtttatcaagttccgcaacaca
cccattgtcaaggccaccaaccgagagctctcctacctcctcctcttctccctgctctgc
tgcttctccagctccctgttcttcatcggggagccccaggactggacgtgccgcctgcgc
cagccggcctttggcatcagcttcgtgctctgcatctcatgcatcctggtgaaaaccaac
cgtgtcctcctggtgtttgaggccaagatccccaccagcttccaccgcaagtggtggggg
ctcaacctgcagttcctgctggttttcctctgcaccttcatgcagattgtcatctgtgtg
atctggctctacaccgcgcccccgtcaagctaccgcaaccaggagctggaggatgagatc
atcttcatcacgtgccacgagggctccctcatggccctgggcttcctgatcggctacacc
tgcctgctggctgccatctgcttcttctttgccttcaagtcccggaagctgccggagaac
ttcaatgaagccaagttcatcaccttcagcatgctcatcttcttcatcgtctggatctcc
ttcattccagcctatgccagcacctatggcaagtttgtctctgccgtagaggtgattgcc
atcctggcagccagctttggcttgctggcgtgcatcttcttcaacaagatctacatcatt
ctcttcaagccatcccgcaacaccatcgaggaggtgcgttgcagcaccgcagctcacgct
ttcaaggtggctgcccgggccacgctgcgccgcagcaacgtctcccgcaagcggtccagc
agccttggaggctccacgggatccaccccctcctcctccatcagcagcaagagcaacagc
gaagacccattcccacagcccgagaggcagaagcagcagcagccgctggccctaacccag
caagagcagcagcagcagcccctgaccctcccacagcagcaacgatctcagcagcagccc
agatgcaagcagaaggtcatctttggcagcggcacggtcaccttctcactgagctttgat
gagcctcagaagaacgccatggcccacaggaattctacgcaccagaactccctggaggcc
cagaaaagcagcgatacgctgacccgacacgagccattactcccgctgcagtgcggggaa
acggacttagatctgaccgtccaggaaacaggtctgcaaggacctgtgggtggagaccag
cggccagaggtggaggaccctgaagagttgtccccagcacttgtagtgtccagttcacag
agctttgtcatcagtggtggaggcagcactgttacagaaaacgtagtgaattcataa |