KEGG   Homo sapiens (human): 8493
Entry
8493              CDS       T01001                                 
Symbol
PPM1D, IDDGIP, JDVS, PP2C-DELTA, WIP1
Name
(RefSeq) protein phosphatase, Mg2+/Mn2+ dependent 1D
  KO
K10147  protein phosphatase 1D [EC:3.1.3.16]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04115  p53 signaling pathway
Disease
H00031  Breast cancer
H02463  Syndromic intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04115 p53 signaling pathway
    8493 (PPM1D)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    8493 (PPM1D)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     8493 (PPM1D)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Mg2+- or Mn2+- dependent protein phosphatases (PPMs)
   PPM1 phosphatases (PP2C)
    8493 (PPM1D)
SSDB
Motif
Pfam: PP2C PP2C_2
Other DBs
NCBI-GeneID: 8493
NCBI-ProteinID: NP_003611
OMIM: 605100
HGNC: 9277
Ensembl: ENSG00000170836
UniProt: O15297 A0A0S2Z4M2
Position
17:60600193..60666280
AA seq 605 aa
MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPG
GEVSGKGPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHL
WGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVII
RGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSG
VNRVVWKRPRLTHNGPVRRSTVIDQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHT
LDPQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQ
RMLRADNTSAIVICISPEVDNQGNFTNEDELYLNLTDSPSYNSQETCVMTPSPCSTPPVK
SLEEDPWPRVNSKDHIPALVRSNAFSENFLEVSAEIARENVQGVVIPSKDPEPLEENCAK
ALTLRIHDSLNNSLPIGLVPTNSTNTVMDQKNLKMSTPGQMKAQEIERTPPTNFKRTLEE
SNSGPLMKKHRRNGLSRSSGAQPASLPTTSQRKNSVKLTMRRRLRGQKKIGNPLLHQHRK
TVCVC
NT seq 1818 nt   +upstreamnt  +downstreamnt
atggcggggctgtactcgctgggagtgagcgtcttctccgaccagggcgggaggaagtac
atggaggacgttactcaaatcgttgtggagcccgaaccgacggctgaagaaaagccctcg
ccgcggcggtcgctgtctcagccgttgcctccgcggccgtcgccggccgcccttcccggc
ggcgaagtctcggggaaaggcccagcggtggcagcccgagaggctcgcgaccctctcccg
gacgccggggcctcgccggcacctagccgctgctgccgccgccgttcctccgtggccttt
ttcgccgtgtgcgacgggcacggcgggcgggaggcggcacagtttgcccgggagcacttg
tggggtttcatcaagaagcagaagggtttcacctcgtccgagccggctaaggtttgcgct
gccatccgcaaaggctttctcgcttgtcaccttgccatgtggaagaaactggcggaatgg
ccaaagactatgacgggtcttcctagcacatcagggacaactgccagtgtggtcatcatt
cggggcatgaagatgtatgtagctcacgtaggtgactcaggggtggttcttggaattcag
gatgacccgaaggatgactttgtcagagctgtggaggtgacacaggaccataagccagaa
cttcccaaggaaagagaacgaatcgaaggacttggtgggagtgtaatgaacaagtctggg
gtgaatcgtgtagtttggaaacgacctcgactcactcacaatggacctgttagaaggagc
acagttattgaccagattccttttctggcagtagcaagagcacttggtgatttgtggagc
tatgatttcttcagtggtgaatttgtggtgtcacctgaaccagacacaagtgtccacact
cttgaccctcagaagcacaagtatattatattggggagtgatggactttggaatatgatt
ccaccacaagatgccatctcaatgtgccaggaccaagaggagaaaaaatacctgatgggt
gagcatggacaatcttgtgccaaaatgcttgtgaatcgagcattgggccgctggaggcag
cgtatgctccgagcagataacactagtgccatagtaatctgcatctctccagaagtggac
aatcagggaaactttaccaatgaagatgagttatacctgaacctgactgacagcccttcc
tataatagtcaagaaacctgtgtgatgactccttccccatgttctacaccaccagtcaag
tcactggaggaggatccatggccaagggtgaattctaaggaccatatacctgccctggtt
cgtagcaatgccttctcagagaattttttagaggtttcagctgagatagctcgagagaat
gtccaaggtgtagtcataccctcaaaagatccagaaccacttgaagaaaattgcgctaaa
gccctgactttaaggatacatgattctttgaataatagccttccaattggccttgtgcct
actaattcaacaaacactgtcatggaccaaaaaaatttgaagatgtcaactcctggccaa
atgaaagcccaagaaattgaaagaacccctccaacaaactttaaaaggacattagaagag
tccaattctggccccctgatgaagaagcatagacgaaatggcttaagtcgaagtagtggt
gctcagcctgcaagtctccccacaacctcacagcgaaagaactctgttaaactcaccatg
cgacgcagacttaggggccagaagaaaattggaaatcctttacttcatcaacacaggaaa
actgtttgtgtttgctga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG ORTHOLOGY (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (35)   
   RefSeq(nuc) (5)   
   GenBank (15)   
   EMBL (15)   
Protein domain (2)   
   Pfam (2)   
All databases (75)   

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