KEGG   Homo sapiens (human): 85015
Entry
85015             CDS       T01001                                 
Symbol
USP45, LCA19
Name
(RefSeq) ubiquitin specific peptidase 45
  KO
K11844  ubiquitin carboxyl-terminal hydrolase 16/45 [EC:3.4.19.12]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03083  Polycomb repressive complex
Disease
H00837  Leber congenital amaurosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    85015 (USP45)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    85015 (USP45)
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    85015 (USP45)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.19  Omega peptidases
    3.4.19.12  ubiquitinyl hydrolase 1
     85015 (USP45)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C19: ubiquitin-specific protease family
   85015 (USP45)
Ubiquitin system [BR:hsa04121]
 Deubiquitinating enzyme (DUB)
  Ubiquitin-specific proteases (UBPs)
   UBP/USP
    85015 (USP45)
SSDB
Motif
Pfam: UCH zf-UBP Rrp44_CSD1 LELP1
Other DBs
NCBI-GeneID: 85015
NCBI-ProteinID: NP_001073950
OMIM: 618439
HGNC: 20080
Ensembl: ENSG00000123552
UniProt: Q70EL2
Position
6:complement(99432325..99517846)
AA seq 814 aa
MRVKDPTKALPEKAKRSKRPTVPHDEDSSDDIAVGLTCQHVSHAISVNHVKRAIAENLWS
VCSECLKERRFYDGQLVLTSDIWLCLKCGFQGCGKNSESQHSLKHFKSSRTEPHCIIINL
STWIIWCYECDEKLSTHCNKKVLAQIVDFLQKHASKTQTSAFSRIMKLCEEKCETDEIQK
GGKCRNLSVRGITNLGNTCFFNAVMQNLAQTYTLTDLMNEIKESSTKLKIFPSSDSQLDP
LVVELSRPGPLTSALFLFLHSMKETEKGPLSPKVLFNQLCQKAPRFKDFQQQDSQELLHY
LLDAVRTEETKRIQASILKAFNNPTTKTADDETRKKVKAYGKEGVKMNFIDRIFIGELTS
TVMCEECANISTVKDPFIDISLPIIEERVSKPLLWGRMNKYRSLRETDHDRYSGNVTIEN
IHQPRAAKKHSSSKDKSQLIHDRKCIRKLSSGETVTYQKNENLEMNGDSLMFASLMNSES
RLNESPTDDSEKEASHSESNVDADSEPSESESASKQTGLFRSSSGSGVQPDGPLYPLSAG
KLLYTKETDSGDKEMAEAISELRLSSTVTGDQDFDRENQPLNISNNLCFLEGKHLRSYSP
QNAFQTLSQSYITTSKECSIQSCLYQFTSMELLMGNNKLLCENCTKNKQKYQEETSFAEK
KVEGVYTNARKQLLISAVPAVLILHLKRFHQAGLSLRKVNRHVDFPLMLDLAPFCSATCK
NASVGDKVLYGLYGIVEHSGSMREGHYTAYVKVRTPSRKLSEHNTKKKNVPGLKAADNES
AGQWVHVSDTYLQVVPESRALSAQAYLLFYERVL
NT seq 2445 nt   +upstreamnt  +downstreamnt
atgcgggtgaaagatccaactaaagctttacctgagaaagccaaaagaagtaaaaggcct
actgtacctcatgatgaagactcttcagatgatattgctgtaggtttaacttgccaacat
gtaagtcatgctatcagcgtgaatcatgtaaagagagcaatagctgagaatctgtggtca
gtttgctcagaatgtttaaaagaaagaagattctatgatgggcagctagtacttacttct
gatatttggttgtgcctcaagtgtggcttccagggatgtggtaaaaactcagaaagccaa
cattcattgaagcactttaagagttccagaacagagccccattgtattataattaatctg
agcacatggattatatggtgttatgaatgtgatgaaaaattatcaacgcattgtaataag
aaggttttggctcagatagttgattttctccagaaacatgcttctaaaacacaaacaagt
gcattttctagaatcatgaaactttgtgaagaaaaatgtgaaacagatgaaatacagaag
ggaggaaaatgcagaaatttatctgtaagaggaattacaaatttaggaaatacttgcttt
tttaatgcagtcatgcagaacttggcacagacttatactcttactgatctgatgaatgag
atcaaagaaagtagtacaaaactcaagatttttccttcctcagactctcagctggaccca
ttggtggtggaactttcaaggcctggaccactgacctcagccttgttcctgtttcttcac
agcatgaaggagactgaaaaaggaccactttctcctaaagttctttttaatcagctttgt
cagaaggcacctcgatttaaagatttccagcaacaggacagtcaggagcttcttcattat
cttctggatgcagtgaggacagaagaaacaaagcgaatacaagctagcattctaaaagca
tttaacaacccaactactaaaactgctgatgatgaaactagaaaaaaagtcaaagcatat
ggaaaagaaggtgtgaaaatgaacttcatagatcggatctttattggtgaattaactagc
acggtcatgtgtgaagaatgtgcaaatatctccacggtgaaagatccattcattgatatt
tcacttcctataatagaagaaagggtttcaaaacctttactttggggaagaatgaataaa
tatagaagtttacgggagacagatcatgatcgatacagtggcaatgttactatagaaaat
attcatcaacctagagctgccaagaagcattcttcatctaaagataagagtcaactaatt
catgaccgaaaatgtattagaaaattgtcatctggagaaactgtcacataccagaaaaat
gaaaaccttgaaatgaatggggattctttaatgtttgccagcctcatgaattctgagtca
cgtctgaatgaaagccctactgatgacagtgaaaaagaagccagccattctgaaagcaat
gttgatgctgacagtgagccttcagaatctgaaagtgcttcaaagcagactgggctgttc
agatccagtagtggatccggtgtgcagccagatggacccctttaccctctgtcagcaggt
aaactgctgtacaccaaggagactgacagtggtgataaggaaatggcagaagctatttct
gaacttcgtttgagcagcactgtaactggagatcaagattttgacagagaaaatcagcca
ctaaatatttcaaataatttatgttttttagaggggaagcatttgaggtcttatagtccc
caaaatgcttttcagaccctttctcagagctatataactacttctaaagaatgttcaatt
cagtcctgtctctaccagtttacatctatggaattactaatggggaataataagcttcta
tgtgagaattgtactaaaaacaaacagaagtaccaagaagaaaccagttttgcagaaaag
aaagtagaaggagtttatactaatgccaggaagcaattgctcatttctgctgttccagct
gtcctaattctccacctgaaaagatttcatcaggctggcttgagtcttcgtaaagtaaac
agacatgtagattttccacttatgctcgatttagcaccattctgctctgctacttgtaag
aatgcaagtgtgggagataaagttctctacggtctctatggcatagtggaacatagtggc
tcgatgagagaaggccactacactgcttatgtgaaagtgagaacaccctccaggaaatta
tcggaacataacactaaaaagaaaaatgtgcctggtttgaaagcggctgataatgaatca
gcaggccagtgggtccatgttagtgacacttacttacaggtggttccagaatcaagagca
cttagtgcacaagcctaccttcttttctatgaaagagtattataa

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (9)   
   OC (1)   
Protein sequence (33)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (31)   
DNA sequence (58)   
   RefSeq(nuc) (36)   
   GenBank (11)   
   EMBL (11)   
Protein domain (4)   
   Pfam (4)   
All databases (126)   

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