KEGG   Homo sapiens (human): 8659
Entry
8659              CDS       T01001                                 
Symbol
ALDH4A1, ALDH4, P5CD, P5CDh
Name
(RefSeq) aldehyde dehydrogenase 4 family member A1
  KO
K00294  1-pyrroline-5-carboxylate dehydrogenase [EC:1.2.1.88]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00250  Alanine, aspartate and glutamate metabolism
hsa00330  Arginine and proline metabolism
hsa01100  Metabolic pathways
Module
hsa_M00970  Proline degradation, proline => glutamate
Network
nt06033  Glycine, serine and arginine metabolism
  Element
N01622  Proline degradation
Disease
H00190  Hyperprolinemia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00250 Alanine, aspartate and glutamate metabolism
    8659 (ALDH4A1)
   00330 Arginine and proline metabolism
    8659 (ALDH4A1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.88  L-glutamate gamma-semialdehyde dehydrogenase
     8659 (ALDH4A1)
SSDB
Motif
Pfam: Aldedh
Other DBs
NCBI-GeneID: 8659
NCBI-ProteinID: NP_003739
OMIM: 606811
HGNC: 406
Ensembl: ENSG00000159423
UniProt: P30038 A0A024RAC7
Structure
Position
1:complement(18871430..18902555)
AA seq 563 aa
MLLPAPALRRALLSRPWTGAGLRWKHTSSLKVANEPVLAFTQGSPERDALQKALKDLKGR
MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP
IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL
EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML
ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ
NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL
WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK
CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG
AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR
WTSPQVIKETHKPLGDWSYAYMQ
NT seq 1692 nt   +upstreamnt  +downstreamnt
atgctgctgccggcgcccgcgctccgccgcgccctgctgtcccgcccctggaccggggcc
ggcctgcggtggaagcacacctcctccctgaaggtggccaacgagcccgtcttagccttc
acgcagggcagccctgagcgagatgccctgcaaaaggccttgaaggacctgaagggccgg
atggaagccatcccatgcgtggtgggggatgaggaggtgtggacgtcggacgtgcagtac
caagtgtcgccttttaaccatggacataaggtggccaagttctgttatgcagacaagagc
ctgctcaacaaagccattgaggctgccctggctgcccggaaagagtgggacctgaagcct
attgcagaccgggcccagatcttcctgaaggcggcagacatgctgagtgggccgcgcagg
gctgagatcctcgccaagaccatggtgggacagggtaagaccgtgatccaagcggagatt
gacgctgcagcggaactcatcgacttcttccggttcaatgccaagtatgcggtggagctg
gaggggcagcagcccatcagcgtgcccccgagcaccaacagcacggtgtaccggggtctg
gagggcttcgtggcggccatctcgccctttaacttcactgcaatcggcggcaacctggcg
ggggcaccggccctgatgggcaacgtggtcctatggaagcccagtgacactgccatgctg
gccagctatgctgtctaccgcatccttcgggaggctggcctgccccccaacatcatccag
tttgtgccagctgatgggcccctatttggggacactgtcaccagctcagagcacctctgt
ggcatcaacttcacaggcagtgtgcccaccttcaaacacctgtggaagcaggtggcccag
aacctggaccggttccacaccttcccacgcctggctggagagtgcggcggaaagaacttc
cacttcgtgcaccgctcggccgacgtggagagcgtggtgagcgggaccctccgctcagcc
ttcgagtacggtggccagaagtgttccgcgtgctcgcgtctctacgtgccgcactcgctg
tggccgcagatcaaagggcggctgctggaggagcacagtcggatcaaagtgggcgaccct
gcagaggattttgggaccttcttctctgcagtgattgatgccaagtcctttgcccgtatc
aagaagtggctggagcacgcacgctcctcacccagcctcaccatcctggccgggggcaag
tgtgatgactccgtgggctactttgtggagccctgcatcgtggagagcaaggaccctcag
gagcccatcatgaaggaggagatcttcgggcctgtactgtctgtgtacgtctacccggat
gacaagtacaaggagacgctgcagctggttgacagcaccaccagctatggcctcacgggg
gcagtgttctcccaggataaggacgtcgtgcaggaggccacaaaggtgctgaggaatgct
gccggcaacttctacatcaacgacaagtccactggctcgatagtgggccagcagcccttt
gggggggcccgagcctctggaaccaatgacaagccagggggcccacactacatcctgcgc
tggacgtcgccgcaggtcatcaaggagacacataagcccctgggggactggagctacgcg
tacatgcagtga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (12)   
   KEGG COMPOUND (12)   
Chemical reaction (8)   
   KEGG ENZYME (1)   
   KEGG REACTION (7)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (7)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (30)   
   RefSeq(nuc) (4)   
   GenBank (13)   
   EMBL (13)   
3D Structure (4)   
   PDB (4)   
Protein domain (1)   
   Pfam (1)   
All databases (89)   

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