KEGG   Homo sapiens (human): 8930
Entry
8930              CDS       T01001                                 
Symbol
MBD4, MED1, TPDS2, UVM1
Name
(RefSeq) methyl-CpG binding domain 4, DNA glycosylase
  KO
K10801  methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03410  Base excision repair
Network
nt06504  Base excision repair
  Element
N01433  Base excision and strand cleavage by monofunctional glycosylase
Disease
H02624  Tumor predisposition syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03410 Base excision repair
    8930 (MBD4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    8930 (MBD4)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    8930 (MBD4)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Heterochromatin formation proteins
   MBPs (metylated DNA binding proteins)
    8930 (MBD4)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    DNA glycosylases
     8930 (MBD4)
SSDB
Motif
Pfam: MBD HhH-GPD
Other DBs
NCBI-GeneID: 8930
NCBI-ProteinID: NP_003916
OMIM: 603574
HGNC: 6919
Ensembl: ENSG00000129071
UniProt: O95243
Structure
Position
3:complement(129430947..129439948)
AA seq 580 aa
MGTTGLESLSLGDRGAAPTVTSSERLVPDPPNDLRKEDVAMELERVGEDEEQMMIKRSSE
CNPLLQEPIASAQFGATAGTECRKSVPCGWERVVKQRLFGKTAGRFDVYFISPQGLKFRS
KSSLANYLHKNGETSLKPEDFDFTVLSKRGIKSRYKDCSMAALTSHLQNQSNNSNWNLRT
RSKCKKDVFMPPSSSSELQESRGLSNFTSTHLLLKEDEGVDDVNFRKVRKPKGKVTILKG
IPIKKTKKGCRKSCSGFVQSDSKRESVCNKADAESEPVAQKSQLDRTVCISDAGACGETL
SVTSEENSLVKKKERSLSSGSNFCSEQKTSGIINKFCSAKDSEHNEKYEDTFLESEEIGT
KVEVVERKEHLHTDILKRGSEMDNNCSPTRKDFTGEKIFQEDTIPRTQIERRKTSLYFSS
KYNKEALSPPRRKAFKKWTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWK
FLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKY
GNDSYRIFCVNEWKQVHPEDHKLNKYHDWLWENHEKLSLS
NT seq 1743 nt   +upstreamnt  +downstreamnt
atgggcacgactgggctggagagtctgagtctgggggaccgcggagctgcccccaccgtc
acctctagtgagcgcctagtcccagacccgccgaatgacctccgcaaagaagatgttgct
atggaattggaaagagtgggagaagatgaggaacaaatgatgataaaaagaagcagtgaa
tgtaatcccttgctacaagaacccatcgcttctgctcagtttggtgctactgcaggaaca
gaatgccgtaagtctgtcccatgtggatgggaaagagttgtgaagcaaaggttatttggg
aagacagcaggaagatttgatgtgtactttatcagcccacaaggactgaagttcagatcc
aaaagttcacttgctaattatcttcacaaaaatggagagacttctcttaagccagaagat
tttgattttactgtactttctaaaaggggtatcaagtcaagatataaagactgcagcatg
gcagccctgacatcccatctacaaaaccaaagtaacaattcaaactggaacctcaggacc
cgaagcaagtgcaaaaaggatgtgtttatgccgccaagtagtagttcagagttgcaggag
agcagaggactctctaactttacttccactcatttgcttttgaaagaagatgagggtgtt
gatgatgttaacttcagaaaggttagaaagcccaaaggaaaggtgactattttgaaagga
atcccaattaagaaaactaaaaaaggatgtaggaagagctgttcaggttttgttcaaagt
gatagcaaaagagaatctgtgtgtaataaagcagatgctgaaagtgaacctgttgcacaa
aaaagtcagcttgatagaactgtctgcatttctgatgctggagcatgtggtgagaccctc
agtgtgaccagtgaagaaaacagccttgtaaaaaaaaaagaaagatcattgagttcagga
tcaaatttttgttctgaacaaaaaacttctggcatcataaacaaattttgttcagccaaa
gactcagaacacaacgagaagtatgaggatacctttttagaatctgaagaaatcggaaca
aaagtagaagttgtggaaaggaaagaacatttgcatactgacattttaaaacgtggctct
gaaatggacaacaactgctcaccaaccaggaaagacttcactggtgagaaaatatttcaa
gaagataccatcccacgaacacagatagaaagaaggaaaacaagcctgtatttttccagc
aaatataacaaagaagctcttagccccccacgacgtaaagcctttaagaaatggacacct
cctcggtcaccttttaatctcgttcaagaaacactttttcatgatccatggaagcttctc
atcgctactatatttctcaatcggacctcaggcaaaatggcaatacctgtgctttggaag
tttctggagaagtatccttcagctgaggtagcaagaaccgcagactggagagatgtgtca
gaacttcttaaacctcttggtctctacgatcttcgggcaaaaaccattgtcaagttctca
gatgaatacctgacaaagcagtggaagtatccaattgagcttcatgggattggtaaatat
ggcaacgactcttaccgaattttttgtgtcaatgagtggaagcaggtgcaccctgaagac
cacaaattaaataaatatcatgactggctttgggaaaatcatgaaaaattaagtctatct
taa

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (4)   
   KEGG DISEASE (1)   
   OMIM (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (11)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (9)   
DNA sequence (35)   
   RefSeq(nuc) (9)   
   GenBank (13)   
   EMBL (13)   
3D Structure (18)   
   PDB (18)   
Protein domain (2)   
   Pfam (2)   
All databases (95)   

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