KEGG   Homo sapiens (human): 9518
Entry
9518              CDS       T01001                                 
Symbol
GDF15, GDF-15, HG, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB
Name
(RefSeq) growth differentiation factor 15
  KO
K05504  growth differentiation factor 15
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
Drug target
Ponsegromab: D11909
Rilogrotug: D12852
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    9518 (GDF15)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    9518 (GDF15)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Transforming growth factors (RSTK binding)
   9518 (GDF15)
SSDB
Motif
Pfam: TGF_beta
Other DBs
NCBI-GeneID: 9518
NCBI-ProteinID: NP_004855
OMIM: 605312
HGNC: 30142
Ensembl: ENSG00000130513
UniProt: Q99988
Structure
Position
19:18386158..18389176
AA seq 308 aa
MPGQELRTVNGSQMLLVLLVLSWLPHGGALSLAEASRASFPGPSELHSEDSRFRELRKRY
EDLLTRLRANQSWEDSNTDLVPAPAVRILTPEVRLGSGGHLHLRISRAALPEGLPEASRL
HRALFRLSPTASRSWDVTRPLRRQLSLARPQAPALHLRLSPPPSQSDQLLAESSSARPQL
ELHLRPQAARGRRRARARNGDHCPLGPGRCCRLHTVRASLEDLGWADWVLSPREVQVTMC
IGACPSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQKTDTGVSLQTYDDL
LAKDCHCI
NT seq 927 nt   +upstreamnt  +downstreamnt
atgcccgggcaagaactcaggacggtgaatggctctcagatgctcctggtgttgctggtg
ctctcgtggctgccgcatgggggcgccctgtctctggccgaggcgagccgcgcaagtttc
ccgggaccctcagagttgcactccgaagactccagattccgagagttgcggaaacgctac
gaggacctgctaaccaggctgcgggccaaccagagctgggaagattcgaacaccgacctc
gtcccggcccctgcagtccggatactcacgccagaagtgcggctgggatccggcggccac
ctgcacctgcgtatctctcgggccgcccttcccgaggggctccccgaggcctcccgcctt
caccgggctctgttccggctgtccccgacggcgtcaaggtcgtgggacgtgacacgaccg
ctgcggcgtcagctcagccttgcaagaccccaggcgcccgcgctgcacctgcgactgtcg
ccgccgccgtcgcagtcggaccaactgctggcagaatcttcgtccgcacggccccagctg
gagttgcacttgcggccgcaagccgccagggggcgccgcagagcgcgtgcgcgcaacggg
gaccactgtccgctcgggcccgggcgttgctgccgtctgcacacggtccgcgcgtcgctg
gaagacctgggctgggccgattgggtgctgtcgccacgggaggtgcaagtgaccatgtgc
atcggcgcgtgcccgagccagttccgggcggcaaacatgcacgcgcagatcaagacgagc
ctgcaccgcctgaagcccgacacggtgccagcgccctgctgcgtgcccgccagctacaat
cccatggtgctcattcaaaagaccgacaccggggtgtcgctccagacctatgatgacttg
ttagccaaagactgccactgcatatga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (2)   
   OMIM (2)   
Drug (2)   
   KEGG DRUG (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG ORTHOLOGY (1)   
   RefGene (16)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (28)   
   RefSeq(nuc) (2)   
   GenBank (13)   
   EMBL (13)   
3D Structure (4)   
   PDB (4)   
Protein domain (1)   
   Pfam (1)   
All databases (72)   

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