KEGG T01001: HTR2C

Homo sapiens (human): 3358

Entry

3358              CDS       T01001

Symbol

HTR2C, 5-HT1C, 5-HT2C, 5-HTR2C, 5HTR2C, HTR1C

Name

(RefSeq) 5-hydroxytryptamine receptor 2C

K04157

5-hydroxytryptamine receptor 2

Organism

hsa Homo sapiens (human)

Pathway

hsa04020

Calcium signaling pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04540

Gap junction

hsa04726

Serotonergic synapse

hsa04750

Inflammatory mediator regulation of TRP channels

Network

nt06528 Calcium signaling

Element

N01640

GPCR-PLCB-ITPR signaling pathway

Drug target

Adatanserin hydrochloride:

D02767

Agomelatine:

D02578

Amesergide:

D02893

Asenapine (DG03100):

D02995<JP/US>

Brolamfetamine:

D12707

Captodiame:

D07316

Chlorpromazine (DG00867):

D00270 D00789<JP/US> D03274 D04034<JP> D09819

Cinitapride (DG01520):

D07700 D07701

Clozapine:

D00283<JP/US>

Cyamemazine (DG00872):

D07307 D07756

Cyproheptadine (DG01109):

D02234<JP/US> D07765

Dimetotiazine (DG00843):

D01902<JP> D07854

Fenfluramine (DG00103):

D04148<JP/US> D07945

Flibanserin:

D02577<US>

Glemanserin:

D04320

Idalopirdine (DG01878):

D10710

Iloperidone:

D02666<US>

Lorcaserin (DG03052):

D06613 D11566

Methysergide (DG00835):

D00681 D02357

Metrenperone:

D05015

Mianserin (DG00951):

D01358<JP> D08216

Mirtazapine (DG02838):

D00563<JP/US> D11056

Nefazodone (DG00953):

D00819<US> D08257

Ocaperidone:

D02675

Olanzapine (DG00898):

D00454<JP/US> D06623<US>

Opipramol (DG00930):

D01477 D08297

Pelanserin hydrochloride:

D05395

Periciazine:

D01485<JP>

Pimavanserin:

D08969<US>

Pizotifen (DG00842):

Ritanserin:

Sergolexole maleate:

Setoperone:

Tedatioxetine (DG01311):

D10170 D10171

Tiospirone hydrochloride:

D02688

Trazodone (DG00952):

D00820<JP/US> D08626

Tropanserin hydrochloride:

D06253

Vabicaserin hydrochloride:

D06660

Xylamidine tosylate:

D06343

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    3358 (HTR2C)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    3358 (HTR2C)
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    3358 (HTR2C)
09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    3358 (HTR2C)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    3358 (HTR2C)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    3358 (HTR2C)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
  Biogenic amine
   Serotonin
    3358 (HTR2C)

SSDB

Motif

Pfam:

7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx DUF1385 UPF0182 Pox_P21

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

X:114584086..114910061

AA seq 458 aa
MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSI
VIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW
PLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWA
ISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYV
LRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTM
QAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVC
SGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTN
EPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV

NT seq 1377 nt +upstreamnt +downstreamnt
atggtgaacctgaggaatgcggtgcattcattccttgtgcacctaattggcctattggtt
tggcaatctgatatttctgtgagcccagtagcagctatagtaactgacattttcaatacc
tccgatggtggacgcttcaaattcccagacggggtacaaaactggccagcactttcaatc
gtcatcataataatcatgacaataggtggcaacatccttgtgatcatggcagtaagcatg
gaaaagaaactgcacaatgccaccaattacttcttaatgtccctagccattgctgatatg
ctagtgggactacttgtcatgcccctgtctctcctggcaatcctttatgattatgtctgg
ccactacctagatatttgtgccccgtctggatttctttagatgttttattttcaacagcg
tccatcatgcacctctgcgctatatcgctggatcggtatgtagcaatacgtaatcctatt
gagcatagccgtttcaattcgcggactaaggccatcatgaagattgctattgtttgggca
atttctataggtgtatcagttcctatccctgtgattggactgagggacgaagaaaaggtg
ttcgtgaacaacacgacgtgcgtgctcaacgacccaaatttcgttcttattgggtccttc
gtagctttcttcataccgctgacgattatggtgattacgtattgcctgaccatctacgtt
ctgcgccgacaagctttgatgttactgcacggccacaccgaggaaccgcctggactaagt
ctggatttcctgaagtgctgcaagaggaatacggccgaggaagagaactctgcaaaccct
aaccaagaccagaacgcacgccgaagaaagaagaaggagagacgtcctaggggcaccatg
caggctatcaacaatgaaagaaaagcttcgaaagtccttgggattgttttctttgtgttt
ctgatcatgtggtgcccatttttcattaccaatattctgtctgttctttgtgagaagtcc
tgtaaccaaaagctcatggaaaagcttctgaatgtgtttgtttggattggctatgtttgt
tcaggaatcaatcctctggtgtatactctgttcaacaaaatttaccgaagggcattctcc
aactatttgcgttgcaattataaggtagagaaaaagcctcctgtcaggcagattccaaga
gttgccgccactgctttgtctgggagggagcttaatgttaacatttatcggcataccaat
gaaccggtgatcgagaaagccagtgacaatgagcccggtatagagatgcaagttgagaat
ttagagttaccagtaaatccctccagtgtggttagcgaaaggattagcagtgtgtga

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