KEGG   Homo sapiens (human): 6532
Entry
6532              CDS       T01001                                 
Symbol
SLC6A4, 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT
Name
(RefSeq) solute carrier family 6 member 4
  KO
K05037  solute carrier family 6 (neurotransmitter transporter, serotonin) member 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04721  Synaptic vesicle cycle
hsa04726  Serotonergic synapse
Disease
H01450  Obsessive-compulsive disorder
Drug target
Alaproclate: D02787
Amitifadine (DG01386): D10088 D10089
Amitriptyline (DG00934): D00809<JP/US> D07448
Amitriptylinoxide: D07449
Amoxapine: D00228<JP/US>
Ampreloxetine (DG03081): D11688 D11689
Centanafadine (DG01858): D10697 D10698
Cidoxepin hydrochloride: D03491
Citalopram (DG00943): D00822<US> D07704 D07705
Clomipramine (DG00929): D00811<JP/US> D07727
Cocaine (DG00808): D00110 D02182<US>
Dapoxetine: D03649
Desipramine (DG00927): D00812<US> D07791
Desvenlafaxine (DG00963): D02570<US> D07793<US> D11619<US>
Dexfenfluramine (DG00105): D03713 D07805
Dexmethylphenidate (DG00972): D03721<US> D07806
Dosulepin (DG00940): D01546<JP> D07872
Doxepin (DG00937): D00814<US> D07875
Duloxetine (DG00962): D01179<JP/US> D07880
Escitalopram (DG00947): D02567<JP/US> D07913
Fenfluramine (DG00103): D04148<JP/US> D07945
Fluoxetine (DG00942): D00326 D00823<US>
Fluvoxamine (DG00946): D00824<JP/US> D07984
Imipramine (DG00928): D00815<JP/US> D08070 D08071<US>
Imipraminoxide (DG01542): D07334 D08072
Indeloxazine (DG02869): D02170 D08077
Levomilnacipran (DG01387): D10072 D10133<US>
Liafensine: D10443
Lofepramine (DG00932): D01285<JP> D08140
Lubazodone hydrochloride: D04788
Mazindol: D00367<JP>
Metamfetamine (DG00968): D02242<JP/US> D08187
Midomafetamine: D11172
Milnacipran (DG00960): D01107<JP/US> D08222
Nortriptyline (DG00935): D00816<JP/US> D08288
Paroxetine (DG00944): D02260<JP/US> D02362 D05374<US> D05375<US>
Phentermine (DG00102): D05458 D05459<US>
Pirandamine hydrochloride: D05491
Protriptyline (DG00936): D00484<US> D08447
Sertraline (DG00945): D00825<JP/US> D02360
Sibutramine (DG00108): D02571 D08513
Tenamfetamine: D12715
Toludesvenlafaxine (DG03141): D11940 D11941
Trazodone (DG00952): D00820<JP/US> D08626
Trimipramine (DG00931): D00394 D02408<JP/US>
Venlafaxine (DG00959): D00821<JP/US> D08670 D12403<US>
Vilazodone (DG00964): D09698 D09699<US>
Vortioxetine (DG00965): D10184 D10185<JP/US> D12544
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    6532 (SLC6A4)
   04721 Synaptic vesicle cycle
    6532 (SLC6A4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6532 (SLC6A4)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC6: Sodium- and chloride-dependent neurotransmitter transporter
   6532 (SLC6A4)
SSDB
Motif
Pfam: SNF 5HT_transport_N
Other DBs
NCBI-GeneID: 6532
NCBI-ProteinID: NP_001036
OMIM: 182138
HGNC: 11050
Ensembl: ENSG00000108576
UniProt: P31645 B2R7Y7
Structure
Position
17:complement(30194319..30235697)
AA seq 630 aa
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV
NT seq 1893 nt   +upstreamnt  +downstreamnt
atggagacgacgcccttgaattctcagaagcagctatcagcgtgtgaagatggagaagat
tgtcaggaaaacggagttctacagaaggttgttcccaccccaggggacaaagtggagtcc
gggcaaatatccaatgggtactcagcagttccaagtcctggtgcgggagatgacacacgg
cactctatcccagcgaccaccaccaccctagtggctgagcttcatcaaggggaacgggag
acctggggcaagaaggtggatttccttctctcagtgattggctatgctgtggacctgggc
aatgtctggcgcttcccctacatatgttaccagaatggagggggggcattcctcctcccc
tacaccatcatggccatttttgggggaatcccgctcttttacatggagctcgcactggga
cagtaccaccgaaatggatgcatttcaatatggaggaaaatctgcccgattttcaaaggg
attggttatgccatctgcatcattgccttttacattgcttcctactacaacaccatcatg
gcctgggcgctatactacctcatctcctccttcacggaccagctgccctggaccagctgc
aagaactcctggaacactggcaactgcaccaattacttctccgaggacaacatcacctgg
accctccattccacgtcccctgctgaagaattttacacgcgccacgtcctgcagatccac
cggtctaaggggctccaggacctggggggcatcagctggcagctggccctctgcatcatg
ctgatcttcactgttatctacttcagcatctggaaaggcgtcaagacctctggcaaggtg
gtgtgggtgacagccaccttcccttatatcatcctttctgtcctgctggtgaggggtgcc
accctccctggagcctggaggggtgttctcttctacttgaaacccaattggcagaaactc
ctggagacaggggtgtggatagatgcagccgctcagatcttcttctctcttggtccgggc
tttggggtcctgctggcttttgctagctacaacaagttcaacaacaactgctaccaagat
gccctggtgaccagcgtggtgaactgcatgacgagcttcgtttcgggatttgtcatcttc
acagtgctcggttacatggctgagatgaggaatgaagatgtgtctgaggtggccaaagac
gcaggtcccagcctcctcttcatcacgtatgcagaagcgatagccaacatgccagcgtcc
actttctttgccatcatcttctttctgatgttaatcacgctgggcttggacagcacgttt
gcaggcttggagggggtgatcacggctgtgctggatgagttcccacacgtctgggccaag
cgccgggagcggttcgtgctcgccgtggtcatcacctgcttctttggatccctggtcacc
ctgacttttggaggggcctacgtggtgaagctgctggaggagtatgccacggggcccgca
gtgctcactgtcgcgctgatcgaagcagtcgctgtgtcttggttctatggcatcactcag
ttctgcagggacgtgaaggaaatgctcggcttcagcccggggtggttctggaggatctgc
tgggtggccatcagccctctgtttctcctgttcatcatttgcagttttctgatgagcccg
ccacaactacgacttttccaatataattatccttactggagtatcatcttgggttactgc
ataggaacctcatctttcatttgcatccccacatatatagcttatcggttgatcatcact
ccagggacatttaaagagcgtattattaaaagtattaccccagaaacaccaacagaaatt
ccttgtggggacatccgcttgaatgctgtgtaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (4)   
   KEGG DISEASE (1)   
   OMIM (3)   
Drug (92)   
   KEGG DRUG (92)   
Genome (1)   
   KEGG GENOME (1)   
Gene (8)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (27)   
   RefSeq(nuc) (1)   
   GenBank (13)   
   EMBL (13)   
3D Structure (27)   
   PDB (27)   
Protein domain (2)   
   Pfam (2)   
All databases (169)   

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