Entry |
|
Symbol |
HUWE1, ARF-BP1, HECTH9, HSPC272, Ib772, LASU1, MRXST, MULE, URE-B1, UREB1
|
Name |
(RefSeq) HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
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KO |
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Organism |
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Pathway |
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Network |
|
Element |
N01756 | PINK-Parkin-independent ubiquitin-mediated mitophagy |
|
Disease |
H00658 | X-linked syndromic intellectual developmental disorder |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04120 Ubiquitin mediated proteolysis
10075 (HUWE1)
09140 Cellular Processes
09141 Transport and catabolism
04137 Mitophagy - animal
10075 (HUWE1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04121 Ubiquitin system [BR:hsa04121]
10075 (HUWE1)
Enzymes [BR:hsa01000]
2. Transferases
2.3 Acyltransferases
2.3.2 Aminoacyltransferases
2.3.2.26 HECT-type E3 ubiquitin transferase
10075 (HUWE1)
Ubiquitin system [BR:hsa04121]
Ubiquitin ligases (E3)
HECT type E3
10075 (HUWE1)
|
SSDB |
|
Motif |
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Other DBs |
|
Structure |
|
Position |
X:complement(53532096..53686719)
|
AA seq |
4374 aa
MKVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDR
FDGILADAGQTVENMSWMLVCDRPEREQLKMLLLAVLNFTALLIEYSFSRHLYSSIEHLT
TLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLLTRLQHLAESWGGKENGFGLA
ECCRDLHMMKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISESPSEIM
ESLTKMYSIPKDKQMLLFTHIRLAHGFSNHRKRLQAVQARLHAISILVYSNALQESANSI
LYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTASYHGFLP
VLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLG
DEQDQITFVTRAVRVVDLITNLDMAAFQSHSGLSIFIYRLEHEVDLCRKECPFVIKPKIQ
RPNTTQEGEEMETDMDGVQCIPQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDGSLPTSL
KHIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNGLTDVMLHALLIKDVPATREV
LGSLPNVFSALCLNARGLQSFVQCQPFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLG
SAVDELMRHQPTLKTDATTAIIKLLEEICNLGRDPKYICQKPSIQKADGTATAPPPRSNH
AAEEASSEDEEEEEVQAMQSFNSTQQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESI
LSNNTTDDHCQEFVNQKGLLPLVTILGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKV
LQEGLLQLDSILSSLEPLHRPIESPGGSVLLRELACAGNVADATLSAQATPLLHALTAAH
AYIMMFVHTCRVGQSEIRSISVNQWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSL
PSGCEFGQADMQKLVPKDEKAGTTQGGKRSDGEQDGAAGSMDASTQGLLEGIGLDGDTLA
PMETDEPTASDSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCVGSPVR
QRRSHHAASTTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSP
MLFDERKYPYHLMLQKFLCSGGHNALFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLD
AWLMLVEKMVNPTTVLESPHSLPAKLPGGVQNFPQFSALRFLVVTQKAAFTCIKNLWNRK
PLKVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGSRGEEDTGQEEGGSRREPQVNQQ
QLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHPPPIMGGVVRDLSMSEEDQMMRAIA
MSLGQDIPMDQRAESPEEVACRKEEEERKAREKQEEEEAKCLEKFQDADPLEQDELHTFT
DTMLPGCFHLLDELPDTVYRVCDLIMTAIKRNGADYRDMILKQVVNQVWEAADVLIKAAL
PLTTSDTKTVSEWISQMATLPQASNLATRILLLTLLFEELKLPCAWVVESSGILNVLIKL
LEVVQPCLQAAKEQKEVQTPKWITPVLLLIDFYEKTAISSKRRAQMTKYLQSNSNNWRWF
DDRSGRWCSYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQFTTMVQVNEETGNRRPVML
TLLRVPRLNKNSKNSNGQELEKTLEESKEMDIKRKENKGNDTPLALESTNTEKETSLEET
KIGEILIQGLTEDMVTVLIRACVSMLGVPVDPDTLHATLRLCLRLTRDHKYAMMFAELKS
TRMILNLTQSSGFNGFTPLVTLLLRHIIEDPCTLRHTMEKVVRSAATSGAGSTTSGVVSG
SLGSREINYILRVLGPAACRNPDIFTEVANCCIRIALPAPRGSGTASDDEFENLRIKGPN
AVQLVKTTPLKPSPLPVIPDTIKEVIYDMLNALAAYHAPEEADKSDPKPGVMTQEVGQLL
QDMGDDVYQQYRSLTRQSSDFDTQSGFSINSQVFAADGASTETSASGTSQGEASTPEESR
DGKKDKEGDRASEEGKQKGKGSKPLMPTSTILRLLAELVRSYVGIATLIANYSYTVGQSE
LIKEDCSVLAFVLDHLLPHTQNAEDKDTPALARLFLASLAAAGSGTDAQVALVNEVKAAL
GRALAMAESTEKHARLQAVMCIISTIMESCPSTSSFYSSATAKTQHNGMNNIIRLFLKKG
LVNDLARVPHSLDLSSPNMANTVNAALKPLETLSRIVNQPSSLFGSKSASSKNKSEQDAQ
GASQDSSSNQQDPGEPGEAEVQEEDHDVTQTEVADGDIMDGEAETDSVVIAGQPEVLSSQ
EMQVENELEDLIDELLERDGGSGNSTIIVSRSGEDESQEDVLMDEAPSNLSQASTLQANR
EDSMNILDPEDEEEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDDD
DGSEMELDEDYPDMNASPLVRFERFDREDDLIIEFDNMFSSATDIPPSPGNIPTTHPLMV
RHADHSSLTLGSGSSTTRLTQGIGRSQRTLRQLTANTGHTIHVHYPGNRQPNPPLILQRL
LGPSAAADILQLSSSLPLQSRGRARLLVGNDDVHIIARSDDELLDDFFHDQSTATSQAGT
LSSIPTALTRWTEECKVLDAESMHDCVSVVKVSIVNHLEFLRDEELEERREKRRKQLAEE
ETKITDKGKEDKENRDQSAQCTASKSNDSTEQNLSDGTPMPDSYPTTPSSTDAATSESKE
TLGTLQSSQQQPTLPTPPALGEVPQELQSPAGEGGSSTQLLMPVEPEELGPTRPSGEAET
TQMELSPAPTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASCTLEEAVGDTSAAGSS
EQPRAGSSTPGDAPPAVAEVQGRSDGSGESAQPPEDSSPPASSESSSTRDSAVAISGADS
RGILEEPLPSTSSEEEDPLAGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTRTAPS
TNSSAPAVVGNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQRRELAQNASSDTPMDPVT
FIQTLPSDLRRSVLEDMEDSVLAVMPPDIAAEAQALRREQEARQRQLMHERLFGHSSTSA
LSAILRSPAFTSRLSGNRGVQYTRLAVQRGGTFQMGGSSSHNRPSGSNVDTLLRLRGRLL
LDHEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWVIRSLLSILQRSSESELCI
ETPKLTTSEEKGKKSSKSCGSSSHENRPLDLLHKMESKSSNQLSWLSVSMDAALGCRTNI
FQIQRSGGRKHTEKHASGGSTVHIHPQAAPVVCRHVLDTLIQLAKVFPSHFTQQRTKETN
CESDRERGNKACSPCSSQSSSSGICTDFWDLLVKLDNMNVSRKGKNSVKSVPVSAGGEGE
TSPYSLEASPLGQLMNMLSHPVIRRSSLLTEKLLRLLSLISIALPENKVSEAQANSGSGA
SSTTTATSTTSTTTTTAASTTPTPPTAPTPVTSAPALVAATAISTIVVAASTTVTTPTTA
TTTVSISPTTKGSKSPAKVSDGGSSSTDFKMVSSGLTENQLQLSVEVLTSHSCSEEGLED
AANVLLQLSRGDSGTRDTVLKLLLNGARHLGYTLCKQIGTLLAELREYNLEQQRRAQCET
LSPDGLPEEQPQTTKLKGKMQSRFDMAENVVIVASQKRPLGGRELQLPSMSMLTSKTSTQ
KFFLRVLQVIIQLRDDTRRANKKAKQTGRLGSSGLGSASSIQAAVRQLEAEADAIIQMVR
EGQRARRQQQAATSESSQSEASVRREESPMDVDQPSPSAQDTQSIASDGTPQGEKEKEER
PPELPLLSEQLSLDELWDMLGECLKELEESHDQHAVLVLQPAVEAFFLVHATERESKPPV
RDTRESQLAHIKDEPPPLSPAPLTPATPSSLDPFFSREPSSMHISSSLPPDTQKFLRFAE
THRTVLNQILRQSTTHLADGPFAVLVDYIRVLDFDVKRKYFRQELERLDEGLRKEDMAVH
VRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYAL
FRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKS
VRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTE
ENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDID
DLKSNTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGI
QKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGLA |
NT seq |
13125 nt +upstreamnt +downstreamnt
atgaaagtagacaggactaaactgaagaagacacctactgaggctcctgcagactgcaga
gccttaatagacaaactcaaagtttgtaatgatgagcaacttctcttggaactgcagcag
atcaaaacatggaacattggaaagtgcgagttatatcactgggtggacctgttggaccgc
ttcgatggaatactggcagatgctggacagacagtggagaatatgtcatggatgctcgta
tgtgataggccagaaagagagcaactgaaaatgcttctcttggctgtgttgaacttcaca
gccttgctcattgagtacagcttttcccggcatctgtacagttccatagagcatttgaca
actttattggcttcctctgatatgcaagtggtgctggcagtcctcaatctcctatatgta
tttagcaaaagatcaaactacatcactcgtctgggatctgacaagaggaccccgctgcta
actcggctacaacatttggcagagagctggggtggaaaggagaatggctttggacttgca
gaatgttgcagagacttgcatatgatgaaatatccacccagtgcaactacactacacttt
gaattctatgcagatcctggggccgaggtcaaaattgagaaaaggacaactagtaacaca
ctacattatattcacatagagcaacttgacaagatttcagaaagcccttctgaaatcatg
gaatctcttaccaaaatgtacagcattcctaaggataagcagatgctgttatttacacac
atacgactggcccatggcttttctaatcacaggaagcgattgcaggcagttcaggccaga
ctgcatgcaatatctatattagtgtattccaatgccttgcaggaatcagcaaacagtatc
ttgtataatggcttgatagaggagttggtagatgtccttcagataacggataagcagctt
atggagattaaagcagcttctttacgaacattaacatcaattgtccacttggagagaact
cccaaactcagcagtattattgactgtactggaactgcctcctaccatggatttttgcca
gtgcttgtaaggaactgtatccaggccatgattgatccttccatggatccataccctcac
cagtttgccactgctctcttctcttttttataccatctggccagctacgatgctggtggt
gaagccttggtctcctgtggaatgatggaagccttattgaaggtcataaagtttcttggc
gatgaacaggaccagataacatttgtcaccagagccgtcagagtggttgaccttatcacc
aacctggatatggcagcttttcaatcccatagtggactttctatcttcatttatagactt
gagcatgaagtagatttgtgccgaaaagaatgtccgtttgtgatcaagccaaagatccag
agacccaatactacacaagaaggagaggaaatggaaactgatatggatggagtccagtgt
attccacaacgagcagcacttctgaaatccatgttgaatttcctcaagaaggccatccaa
gaccctgctttctcagatggcatacgacatgtgatggatggttctctgcctacctccctg
aaacacatcatcagcaatgcagaatactatggcccatcactcttcctcctagctactgaa
gtggtgactgtgtttgtatttcaagaaccatcactgctctcctcactccaggacaatgga
ttgacagatgtcatgctgcatgcactgcttatcaaagatgttcctgctacccgtgaagtc
cttggctccctcccaaatgtattcagtgcactctgtttgaatgcccgaggtcttcagtct
tttgttcagtgtcagccttttgaacgcctcttcaaagttcttctgtctccagattacctc
ccagccatgcggaggaggagaagttctgatccccttggggatactgcatccaacctgggg
agtgctgtcgatgagctcatgagacatcagcccacccttaaaacagatgcaacgactgcc
atcatcaagttacttgaagaaatctgtaatcttggaagggaccccaaatacatctgtcag
aagccatcaatccagaaggcagatggcactgccactgctcctcccccaaggtctaatcat
gccgcagaagaagcctctagtgaggatgaggaggaagaggaagtacaggccatgcagagc
tttaattctacccagcaaaatgaaactgagcctaatcagcaggttgttggtacagaggaa
cgtattcctattcccctcatggattacatccttaatgtgatgaaatttgtggaatctatt
ctgagcaacaatacaacagatgaccactgccaggaatttgtgaatcagaaaggactgttg
cctttggttaccattttgggtcttcccaatctgcccattgactttcccacatctgctgcc
tgtcaggctgttgcaggtgtctgcaaatccatattgacactgtcacatgaacccaaagtc
cttcaagagggtctccttcagttggactccatcctctcctccctggagcccttacaccgc
cccattgaatcccctgggggctcagtgttgttgcgagaactggcttgcgcaggcaatgtt
gctgatgctaccctctcagcccaggccacacctctgctgcatgcactcactgctgcccat
gcctacatcatgatgtttgttcatacttgcagagttggacagagtgaaattcgttccatc
tccgtaaaccagtggggctctcaattgggtctgagtgttttgagcaagctgagccagtta
tactgttccctggtgtgggaaagcactgtcctcctctctctgtgtaccccaaacagccta
ccatctgggtgtgaatttggccaggcagatatgcagaaactggttccaaaggatgagaag
gcaggtacgacccagggcggaaaaagatcagatggggaacaggatggagcagctggaagt
atggatgcttctacccagggcttattagaaggcattgggctagatggtgacacattggct
cccatggagacagatgaacctactgcttcagactctaagggcaaatctaaaatcacacca
gcaatggctgccagaattaagcaaatcaagcctttgttatcagcttcctccagattaggc
cgagcacttgctgagctatttggacttcttgttaaactttgtgtgggatctcctgtccgc
cagagaaggagccatcatgctgccagcaccactacagcaccgacacctgccgcgcgatca
acagcctcagctctcactaagctcttgactaaggggttatcttggcagcccccaccatat
acacctactccccgattcaggctgacattcttcatctgttcagttggtttcacatcccca
atgctgtttgatgagaggaagtatccctaccacctcatgctgcaaaaatttctctgctcc
ggaggccacaatgctctttttgaaactttcaactgggctctgtccatgggaggtaaagtt
cctgtttctgagggattggaacactcagacttgcctgatggcacaggagaattcctagat
gcctggcttatgctggtggagaagatggtgaatcccaccacggtgcttgaatctccacat
tcgctgcctgccaaattgcctggaggtgtccagaactttccccagttcagtgcactgcgc
ttccttgtggtaactcagaaagcagcctttacttgcatcaaaaacttatggaaccggaaa
cccctgaaggtatatggtggacgaatggctgaatcgatgctggccattctatgccacatc
ctccgaggagaacctgtgattcgagagagactaagcaaggagaaggaggggtctcgagga
gaagaggatacagggcaagaggaaggtggctcccgccgggaacctcaagtcaaccagcaa
caactgcaacagctcatggacatgggcttcacaagggaacatgcaatggaggcactgttg
aacaccagcaccatggagcaggccacagagtaccttttaacccaccctcctccaatcatg
ggaggagttgttcgggatctcagcatgtctgaagaggaccagatgatgagagcaattgct
atgtctctgggacaggatattccaatggatcaaagggcagagtcacctgaggaagttgct
tgccggaaggaggaagaggaacggaaagctcgggaaaagcaggaggaggaagaggctaaa
tgtctagagaagttccaggatgctgacccgttggaacaagatgagctccacactttcaca
gatactatgttgccaggctgcttccaccttcttgatgagctgccagacacagtataccgt
gtgtgtgacctgatcatgacagcaatcaaacgtaatggagcagattatcgtgacatgatt
ctgaagcaagtagtcaatcaggtgtgggaagctgctgatgtattgatcaaagctgctctt
cccctgacaacaagtgacacaaaaaccgtgtcagagtggataagtcagatggccacactg
ccccaggcctccaatttggctactagaatcttgcttttaacgctactttttgaggagttg
aagctaccttgtgcttgggtggttgaatcaagtggcatccttaatgtcctaatcaaactc
ttggaagtggttcagccctgcctccaggcagccaaggagcagaaggaagtccagacccca
aagtggatcacaccagtgttgctcctgattgatttctatgaaaagacagccatctcctca
aaaaggagagcccagatgactaagtacctgcaatccaacagcaacaactggcgctggttt
gatgatcgctctgggcgttggtgtagttacagtgcaagcaacaatagcactattgattct
gcctggaaatctggagagacaagcgtgcgattcactgcaggccgaagaagatacacggtc
caattcactacaatggtgcaggttaatgaggaaacagggaaccgacgccctgtgatgctg
actctcctcagggtacctcggctgaataaaaattcaaaaaacagcaatggacaggaacta
gagaagacgctggaagaaagcaaagaaatggatatcaaacgtaaagaaaataaaggcaat
gatacccctttggccctagagagtacaaacactgaaaaggagacaagcctggaggaaaca
aaaatcggggagatcctgatccagggcttgacagaagatatggtgactgttttaatccgg
gcctgcgtgagcatgctgggagtccctgtggacccagatactttgcatgccacccttcgt
ctctgtctgaggctcacccgggaccacaaatatgccatgatgtttgcagaactgaagagt
acccgcatgatcttgaatttgacccagagctcaggcttcaatgggtttactcccctggtc
acccttctcttaagacacatcattgaggacccctgtacccttcgtcataccatggaaaag
gttgttcgctcagcagctacaagtggagctggtagcactacctctggtgttgtgtctggc
agcctcggctctcgggagatcaactacatccttcgtgtccttgggccagccgcatgccgc
aatccagacatattcacagaagtggccaactgctgtatccgcatcgcccttcctgcccct
cgaggctcaggaactgcttcagatgatgaatttgagaatcttagaattaaaggccctaat
gctgtacagctggtgaagaccacccctttgaagccctcacctctgcctgtcatccctgat
actatcaaggaagtgatctatgatatgctgaatgctctggctgcataccatgctccagag
gaagcagataaatctgatcctaaacctggggttatgacccaagaggttggccagctcctg
caagacatgggtgatgatgtataccagcagtaccggtcacttacgcgtcagagcagtgac
tttgatacgcagtcaggtttttccattaatagtcaggtctttgctgcagatggtgcctcc
actgagacttccgcatctgggacctcccaaggagaggcttcaactccagaggagtctcga
gatgggaagaaagataaagaaggggaccgggcctctgaggaaggcaaacagaaaggcaag
ggcagcaaacctttaatgcctacctccactatccttcgtcttctggcagagttggtgagg
tcctatgttggtattgctaccctgattgccaactacagctacactgtgggccagtctgaa
ctgatcaaagaggactgcagtgtgctagcttttgttctggaccacctgctcccacatacc
cagaatgcagaagacaaggacacccctgccttggcccgcctgttcctcgcaagcctggct
gctgcagggagtggcacagatgcccaggtggccctagtgaatgaagtaaaagcagccctt
ggacgggcactggctatggctgagagtacagagaaacatgccaggcttcaggcagtgatg
tgtatcatcagtactatcatggagtcctgcccctccacctccagcttctacagcagtgcc
acagcgaagacccagcacaatggcatgaacaacatcattcggcttttcctgaagaaggga
ctggttaatgacctggccagagtacctcacagcttagacctgtccagtcccaacatggcc
aacacagtcaatgctgctctgaagcctttggaaacactttcccggattgtgaaccagccc
agtagcctttttggcagcaagagtgcttctagcaagaacaagtctgagcaggatgcccaa
ggagcctctcaagattccagtagcaaccagcaggacccaggcgagcctggggaagcagaa
gtgcaggaggaggatcatgatgtcactcagacagaggtggcagatggggatatcatggat
ggggaggctgaaaccgactcagtggtgattgctgggcagcctgaggtgctcagttcacaa
gagatgcaggttgagaatgagctggaggacctgatagatgagttgcttgagagggatggc
ggatctgggaacagtacaattatagtgagcagaagtggagaggatgaatcacaagaggac
gtgctgatggatgaagctccttccaacctcagccaagcttccaccttgcaggccaaccga
gaagattccatgaatatcctggaccctgaggatgaggaggagcacactcaggaagaggac
agcagtggcagtaacgaggatgaggatgatagtcaggatgaagaggaggaggaggaggaa
gatgaggaagatgatcaggaggatgatgaaggtgaagagggagatgaagacgatgacgac
gatggctctgagatggaattggatgaggattatcctgatatgaacgcttctcccttggtc
cgatttgagcgctttgaccgggaggatgatctcatcattgagtttgacaacatgttctcc
agtgctacagacatccccccatccccaggaaatatccctaccacccatccactgatggtg
cgccatgcagaccacagttctctgacactgggcagtggctcttcaacaactcgtctcacc
cagggcatcgggcgcagtcagaggaccctaaggcagctgacggccaatactggccacacc
attcatgttcactaccctgggaatcgccagcccaaccctcctcttatactgcagaggttg
cttggtccctcagctgctgctgacatccttcagctgagcagcagccttcccctacaaagc
cggggtcgggcccgcctcctggtaggcaacgatgacgtccacatcatcgcccgttctgat
gatgagctgctggatgactttttccatgatcagagcacagctaccagccaagcaggaacc
ctgtccagcatccccacagccctgacccgctggacagaagaatgcaaagttctcgatgct
gagagcatgcatgactgtgtttcagtggttaaagtgtccattgtcaatcacctggaattc
ctgagggatgaggagctggaagaaaggcgagagaagcgcaggaaacaactggctgaggaa
gaaacaaagataactgataaaggcaaagaagataaggagaacagggatcagagtgcacag
tgtactgcatctaagtcaaatgactccactgaacagaatctctcagatgggacgcctatg
cctgacagctacccaacaaccccatcttcaactgatgcagctacatctgagtccaaggag
acccttggcactctgcaatcctcacaacagcaaccaacactcccaaccccaccagctttg
ggagaggttcctcaggagctgcagtctccagctggagaagggggcagctctacacagcta
ttgatgcctgtagagccagaggaattgggtcccacaaggccaagtggggaagcagaaaca
actcagatggagttatccccagctcccactataacctcactttccccagagagagctgag
gattctgatgcactgacggctgtcagcagtcagctagaaggctctcctatggatacaagc
agcctggcttcctgtaccttagaggaggctgtgggtgacacttcagcagctggcagttct
gagcagcccagagcaggcagctccactcctggggatgccccaccagctgtggcggaagtg
caaggcaggagtgatgggtcaggggaatctgcccagccacctgaggacagctccccacct
gcatcctctgagagctcttccaccagagattctgccgtggccatttctggagcagattcc
cgaggaatcctagaagagccgttgccttcaacaagcagtgaagaagaagatccccttgcg
ggtatcagtctccctgaaggtgtggacccctcttttctggctgccctgcctgatgacatc
cgtcgggaagttctacagaaccagctaggcattcgtccaccaacccggactgccccctcc
acaaatagctcagcgcctgcagtggtggggaatcctggtgtgactgaagtgagccctgag
tttctggctgccctgcctccagccattcaggaggaagtactggcacagcagagagctgag
cagcagcgacgagaactagcacagaatgccagctcagacacccctatggaccctgtgacc
ttcatccagactctgccctcagacctgcgccgtagtgtcctagaggatatggaggacagt
gtgttagctgtgatgccacctgacattgcagctgaggctcaagccctgagacgagagcaa
gaagcccggcagcgacagctcatgcatgagcgtctgtttgggcacagtagcacctccgca
ctctctgctattctccgaagcccggctttcaccagtcgcttaagtggcaaccgtggggtc
cagtatactcgccttgctgtgcagagaggtggcaccttccagatggggggtagcagcagc
cataacaggccttctggcagtaatgtagatactctcctccgcctccgaggacggctcctt
ctggaccacgaagccctttcttgtctcttggtcctactttttgtggatgagccaaagctc
aatactagccgtctacaccgagtactgagaaatctctgctaccatgcccagacccgccac
tgggtcatccgcagtctgctctccatcttgcagcgcagcagtgagagtgagctatgcatt
gaaacacccaaactcactacaagtgaggaaaagggcaaaaagtcgagcaagagctgtggg
tcaagtagccatgagaaccgtcccctggacctgctacacaagatggagtcaaagagctcc
aaccagctttcctggctctcagtatccatggatgcagccctaggctgcaggactaatata
tttcagatccagcgttcaggggggcgtaaacataccgagaagcatgcaagcggtggctcc
accgtccacatccatccccaagctgctcctgttgtctgcagacacgttttggatacactc
attcaattggccaaggtatttcccagccacttcacacagcagcggaccaaagaaacaaac
tgtgagagtgatcgggaaaggggcaataaggcctgtagcccatgctcctcacagtcctcc
agcagtggcatttgcacagacttctgggacttattggtaaaactggacaacatgaatgtc
agccggaaaggcaagaactccgtgaagtcagtgccagtgagcgctggcggtgagggggaa
acctctccatacagcctcgaggcctctccactggggcagctcatgaacatgttgtcacac
ccagtcatccgccggagctctctcttaactgagaaactcctcagactcctttctctcatc
tcaattgctctcccagaaaacaaggtgtcagaagcacaggctaattctggcagcggtgct
tcctccaccaccactgccacctcaaccacatctaccaccaccaccactgccgcctccacc
acgcccacaccccctactgcacccacccctgtcacttctgctccagccctggttgctgcc
acggctatttccaccattgtcgtagctgcttcgaccacagtgactacccccacgactgct
accactactgtttcaatttctcccactactaagggcagcaaatctccagcgaaggtgagt
gatgggggcagcagcagtacagactttaagatggtgtcctctggcctcactgaaaaccag
ctacagctctctgtagaggtgttgacatcccactcttgttctgaggaaggcttagaggat
gcagccaacgtactactgcagctctcccggggggactctgggacccgggacactgttctc
aagctgctactgaatggagcccgccatctgggttataccctttgtaaacaaataggtacc
ctgctggccgagctgcgggaatacaacctcgagcagcagcggcgagcccaatgtgaaacc
ctctctcctgatggcctgcctgaggagcagccacagaccaccaagctgaagggcaaaatg
cagagcaggtttgacatggctgagaatgtggtaattgtggcatctcagaagcgacctttg
ggtggccgggagctccagctgccttctatgtccatgttgacatccaagacatctacccag
aagttcttcttgagggtactacaggtcatcatccagctccgggacgacacgcgccgggct
aacaagaaagccaagcagacaggcaggctaggttcctccggtttaggctcagctagcagc
atccaggcagctgttcggcagctggaggctgaggctgatgccattatacaaatggtacgt
gagggtcaaagggcgcggagacagcaacaagcagcaacgtcggagtctagccagtcagag
gcgtctgtccggagggaggaatcacccatggatgtggaccagccatctcccagtgctcaa
gatactcaatccattgcctccgatggaaccccacagggggagaaggaaaaggaagaaaga
ccacctgagttacccctgctcagcgagcagctgagtttggacgagctgtgggacatgctt
ggggagtgtctaaaggaactagaggaatcccatgaccagcatgcggtgctagtgctacag
cctgctgtcgaggccttctttctggtccatgccacagagcgggagagcaagcctcctgtc
cgagacacccgtgagagccagctggcacacatcaaggacgagcctcctccactctcccct
gcccccttaaccccagccacgccttcctcccttgacccattcttctcccgggagccctca
tctatgcacatctcctcaagcctgccccctgacacacagaagttccttcgctttgcagag
actcaccgcactgtgttaaaccagatcctacggcagtccacgacccaccttgctgatggg
ccttttgctgtcctggtagactacattcgtgtcctcgactttgatgtcaagcgcaaatat
ttccgccaagagctggagcgtttagatgaggggctccggaaagaagacatggctgtgcat
gtccgtcgtgaccatgtgtttgaagactcctatcgtgagctgcatcgcaaatcccccgaa
gaaatgaagaatcgattgtatatagtatttgaaggagaagaagggcaggatgctggtggg
ctcctgcgggagtggtatatgatcatctctcgagagatgtttaaccctatgtatgccttg
ttccgtacctcacctggtgatcgagtcacctacaccatcaatccatcttcccactgcaac
cccaaccacctcagctacttcaagtttgtcggacgcattgtggccaaagctgtatatgac
aaccgtcttctggagtgctactttactcgatccttttacaaacacatcttgggcaagtca
gtcagatatacagatatggagagtgaagattaccacttctaccaaggtctggtttatctg
ctggaaaatgatgtctccacactaggctatgacctcaccttcagcactgaggtccaagag
tttggagtttgtgaagttcgtgacctcaaacccaatggggccaacatcttggtaacagag
gagaataagaaggagtatgtacacctggtatgccagatgagaatgacaggagccatccgc
aagcagttggcggctttcttagaaggcttctatgagatcattccaaagcgcctcatttcc
atcttcactgagcaggagttagagctgcttatatcaggactgcccaccattgacatcgat
gatctgaaatccaacactgaataccacaagtaccagtccaactctattcagatccagtgg
ttctggagagcattgcgttctttcgatcaagctgaccgtgccaagttcctccagtttgtc
acaggtacttccaaggtacccctgcaaggctttgctgccctcgaaggcatgaatggcatt
cagaagtttcagatccatcgagatgacaggtccacagatcgcctgccttcagctcacaca
tgttttaatcagctggatctgcctgcctatgagagctttgagaagctccgccacatgcta
ctgttggctatccaggagtgctctgaaggctttgggctggcctaa |