KEGG   Homo sapiens (human): 10135
Entry
10135             CDS       T01001                                 
Symbol
NAMPT, 1110035O14Rik, PBEF, PBEF1, VF, VISFATIN
Name
(RefSeq) nicotinamide phosphoribosyltransferase
  KO
K03462  nicotinamide phosphoribosyltransferase [EC:2.4.2.12]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00760  Nicotinate and nicotinamide metabolism
hsa01100  Metabolic pathways
hsa04621  NOD-like receptor signaling pathway
Drug target
Teglarinad chloride: D09678
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    10135 (NAMPT)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    10135 (NAMPT)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    10135 (NAMPT)
Enzymes [BR:hsa01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.2  Pentosyltransferases
    2.4.2.12  nicotinamide phosphoribosyltransferase
     10135 (NAMPT)
Cytokines and neuropeptides [BR:hsa04052]
 Neuropeptides
  Neuropeptides (Unclassified)
   10135 (NAMPT)
SSDB
Motif
Pfam: NAPRTase NAMPT_N NAPRTase_C
Other DBs
NCBI-GeneID: 10135
NCBI-ProteinID: NP_005737
OMIM: 608764
HGNC: 30092
Ensembl: ENSG00000105835
UniProt: P43490
Structure
Position
7:complement(106248298..106285888)
AA seq 491 aa
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
NT seq 1476 nt   +upstreamnt  +downstreamnt
atgaatcctgcggcagaagccgagttcaacatcctcctggccaccgactcctacaaggtt
actcactataaacaatatccacccaacacaagcaaagtttattcctactttgaatgccgt
gaaaagaagacagaaaactccaaattaaggaaggtgaaatatgaggaaacagtattttat
gggttgcagtacattcttaataagtacttaaaaggtaaagtagtaaccaaagagaaaatc
caggaagccaaagatgtctacaaagaacatttccaagatgatgtctttaatgaaaaggga
tggaactacattcttgagaagtatgatgggcatcttccaatagaaataaaagctgttcct
gagggctttgtcattcccagaggaaatgttctcttcacggtggaaaacacagatccagag
tgttactggcttacaaattggattgagactattcttgttcagtcctggtatccaatcaca
gtggccacaaattctagagagcagaagaaaatattggccaaatatttgttagaaacttct
ggtaacttagatggtctggaatacaagttacatgattttggctacagaggagtctcttcc
caagagactgctggcataggagcatctgctcacttggttaacttcaaaggaacagataca
gtagcaggacttgctctaattaaaaaatattatggaacgaaagatcctgttccaggctat
tctgttccagcagcagaacacagtaccataacagcttgggggaaagaccatgaaaaagat
gcttttgaacatattgtaacacagttttcatcagtgcctgtatctgtggtcagcgatagc
tatgacatttataatgcgtgtgagaaaatatggggtgaagatctaagacatttaatagta
tcaagaagtacacaggcaccactaataatcagacctgattctggaaaccctcttgacact
gtgttaaaggttttggagattttaggtaagaagtttcctgttactgagaactcaaagggt
tacaagttgctgccaccttatcttagagttattcaaggggatggagtagatattaatacc
ttacaagagattgtagaaggcatgaaacaaaaaatgtggagtattgaaaatattgccttc
ggttctggtggaggtttgctacagaagttgacaagagatctcttgaattgttccttcaag
tgtagctatgttgtaactaatggccttgggattaacgtcttcaaggacccagttgctgat
cccaacaaaaggtccaaaaagggccgattatctttacataggacgccagcagggaatttt
gttacactggaggaaggaaaaggagaccttgaggaatatggtcaggatcttctccatact
gtcttcaagaatggcaaggtgacaaaaagctattcatttgatgaaataagaaaaaatgca
cagctgaatattgaactggaagcagcacatcattag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (28)   
   RefSeq(nuc) (6)   
   GenBank (11)   
   EMBL (11)   
3D Structure (81)   
   PDB (81)   
Protein domain (3)   
   Pfam (3)   
All databases (150)   

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