KEGG   Homo sapiens (human): 10157
Entry
10157             CDS       T01001                                 
Symbol
AASS, LKR/SDH, LKRSDH, LORSDH
Name
(RefSeq) aminoadipate-semialdehyde synthase
  KO
K14157  alpha-aminoadipic semialdehyde synthase [EC:1.5.1.8 1.5.1.9]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00310  Lysine degradation
hsa01100  Metabolic pathways
Module
hsa_M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
Network
nt06036  Lysine degradation
  Element
N01685  Lysine degradation 1
Disease
H00188  Hyperlysinemia
H01242  Saccharopinuria
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    10157 (AASS)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.8  saccharopine dehydrogenase (NADP+, L-lysine-forming)
     10157 (AASS)
    1.5.1.9  saccharopine dehydrogenase (NAD+, L-glutamate-forming)
     10157 (AASS)
SSDB
Motif
Pfam: Sacchrp_dh_C AlaDh_PNT_N Sacchrp_dh_NADP AlaDh_PNT_C Shikimate_DH
Other DBs
NCBI-GeneID: 10157
NCBI-ProteinID: NP_005754
OMIM: 605113
HGNC: 17366
Ensembl: ENSG00000008311
UniProt: Q9UDR5 A4D0W4
Structure
Position
7:complement(122073549..122144249)
AA seq 926 aa
MLQVHRTGLGRLGVSLSKGLHHKAVLAVRREDVNAWERRAPLAPKHIKGITNLGYKVLIQ
PSNRRAIHDKDYVKAGGILQEDISEACLILGVKRPPEEKLMSRKTYAFFSHTIKAQEANM
GLLDEILKQEIRLIDYEKMVDHRGVRVVAFGQWAGVAGMINILHGMGLRLLALGHHTPFM
HIGMAHNYRNSSQAVQAVRDAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQAIFNELPC
EYVEPHELKEVSQTGDLRKVYGTVLSRHHHLVRKTDAVYDPAEYDKHPERYISRFNTDIA
PYTTCLINGIYWEQNTPRLLTRQDAQSLLAPGKFSPAGVEGCPALPHKLVAICDISADTG
GSIEFMTECTTIEHPFCMYDADQHIIHDSVEGSGILMCSIDNLPAQLPIEATECFGDMLY
PYVEEMILSDATQPLESQNFSPVVRDAVITSNGTLPDKYKYIQTLRESRERAQSLSMGTR
RKVLVLGSGYISEPVLEYLSRDGNIEITVGSDMKNQIEQLGKKYNINPVSMDICKQEEKL
GFLVAKQDLVISLLPYVLHPLVAKACITNKVNMVTASYITPALKELEKSVEDAGITIIGE
LGLDPGLDHMLAMETIDKAKEVGATIESYISYCGGLPAPEHSNNPLRYKFSWSPVGVLMN
VMQSATYLLDGKVVNVAGGISFLDAVTSMDFFPGLNLEGYPNRDSTKYAEIYGISSAHTL
LRGTLRYKGYMKALNGFVKLGLINREALPAFRPEANPLTWKQLLCDLVGISPSSEHDVLK
EAVLKKLGGDNTQLEAAEWLGLLGDEQVPQAESILDALSKHLVMKLSYGPEEKDMIVMRD
SFGIRHPSGHLEHKTIDLVAYGDINGFSAMAKTVGLPTAMAAKMLLDGEIGAKGLMGPFS
KEIYGPILERIKAEGIIYTTQSTIKP
NT seq 2781 nt   +upstreamnt  +downstreamnt
atgctgcaagtacataggactggactgggcaggctgggggtcagcctctccaagggtctt
caccacaaagctgtgttggccgtccggagggaggatgtgaacgcctgggagagaagggcc
ccgctagctcccaagcacatcaaaggcatcaccaatctgggatacaaggtcttgatacag
ccttcgaatcggcgggccattcatgataaggactatgtcaaagctggtggcattcttcag
gaggatatttctgaagcttgtctaattttaggagttaaaagacctccagaggaaaaatta
atgtccaggaagacttatgcatttttctcccacacaataaaagctcaggaggccaatatg
ggcttgttggatgagattctaaaacaggaaattcgccttattgattatgagaaaatggtg
gatcatagaggagtacgggtagtggcatttggacagtgggctggtgtggcaggaatgatc
aacattttacatggaatgggtttaaggctccttgctttgggacatcacacaccttttatg
cacattggcatggctcataactacaggaatagcagtcaggctgtgcaagctgtccgtgat
gctggctatgaaatatctttgggtttgatgcctaagtcaataggacccttaacatttgtg
ttcacaggaactggtaatgtttctaagggagcccaagcaatctttaatgagctaccttgt
gaatatgtggagccccatgaattaaaagaagtttcccaaactggagacctcagaaaagtg
tatgggacggtgttaagtcgtcatcatcatcttgtcaggaaaacagatgctgtgtatgat
cctgcagagtatgacaaacatccggagcgctacataagtcgttttaatactgatattgca
ccctatacaacttgcttaattaatggaatctactgggaacaaaacactcctcgcctccta
acccgccaagatgctcagagtctcctggctccgggcaagttctcacctgctggtgtggaa
ggctgccctgcattaccacacaaactcgtggcaatatgtgacatttcagctgacacagga
gggtctatagagtttatgactgagtgtacaacaatagagcatcccttttgcatgtatgat
gcagaccagcatattattcatgacagtgttgaaggctcggggatcctgatgtgttccatt
gacaatttgccggcacagctcccaattgaagctacagaatgctttggagacatgctttac
ccttatgttgaagaaatgatattatcagacgcgacacagcctcttgaaagtcagaatttt
tctcctgtggtgagagatgcagtgattacatccaacggtacattacctgataaatataaa
tatatccagacactccgggagagcagggaacgtgctcagtcactttcaatgggcaccagg
agaaaggttttggttcttggatctggctacatatctgagcctgtattagaatatttatca
agagatggcaatatagaaataacagtaggatctgacatgaagaatcaaattgaacagtta
ggcaagaaatataatattaatcctgttagcatggacatttgtaaacaagaagagaagctg
ggcttcttggtggcaaaacaggatcttgtcatcagcttgttgccttatgtattgcaccct
cttgtggccaaggcctgcatcacaaacaaagttaacatggtcactgcaagctacatcaca
ccagcactaaaagaattggaaaagagtgtggaagatgctggcatcacaatcattggtgaa
ttgggattggaccctggtctggatcacatgttagcaatggaaacaatagataaagccaag
gaagtgggagccacgattgaatcatatatttcctactgtggtgggcttccagcccctgaa
cattcaaacaatccattgagatataaatttagctggagtccagtgggagttttgatgaat
gtaatgcagtctgccacctatctgctcgatggaaaggttgtgaatgttgcaggaggcatc
tcctttcttgatgccgttacgtccatggatttttttccaggattaaatttggaaggctat
cctaacagagacagtacgaaatatgctgagatttatggcatttcttctgctcacactttg
ttgcgggggacactgagatataagggatatatgaaagctttgaatggatttgtaaaatta
ggtcttataaacagagaagcgcttcctgcctttagacctgaggccaaccctctcacctgg
aaacaactcctctgtgacctagttgggatttcaccctcctctgagcatgatgtgttgaag
gaagctgttcttaagaaactaggaggagacaatacccagttggaggctgctgaatggttg
ggcttacttggggatgaacaagttcctcaggcagagtccattctggatgccctctccaag
catttggtcatgaagctttcctatggtcctgaagaaaaagatatgattgtgatgagagac
agctttggaatcagacatccttctggacatttagaacataaaacgattgatcttgtggct
tatggggacatcaatggcttttcagccatggctaaaaccgtggggttacccaccgccatg
gcagccaaaatgttgcttgatggtgaaattggagccaaaggcctaatggggcccttttca
aaggagatctatggaccaatattggagcgaattaaagcagaaggcattatatatactaca
cagagtacaattaaaccataa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (2)   
   KEGG MODULE (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (4)   
   KEGG DISEASE (2)   
   OMIM (2)   
Chemical substance (11)   
   KEGG COMPOUND (11)   
Chemical reaction (4)   
   KEGG ENZYME (2)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (10)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (29)   
   RefSeq(nuc) (11)   
   GenBank (9)   
   EMBL (9)   
3D Structure (9)   
   PDB (9)   
Protein domain (5)   
   Pfam (5)   
All databases (91)   

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