KEGG   Homo sapiens (human): 10189
Entry
10189             CDS       T01001                                 
Symbol
ALYREF, ALY, ALY/REF, BEF, REF, THOC4
Name
(RefSeq) Aly/REF export factor
  KO
K12881  THO complex subunit 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa03013  Nucleocytoplasmic transport
hsa03015  mRNA surveillance pathway
hsa03040  Spliceosome
hsa05014  Amyotrophic lateral sclerosis
hsa05168  Herpes simplex virus 1 infection
Network
nt06464  Amyotrophic lateral sclerosis
  Element
N01152  Nuclear export of mRNA
N01153  Mutation-caused aberrant GLE1 to nuclear export of mRNA
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09121 Transcription
   03040 Spliceosome
    10189 (ALYREF)
  09122 Translation
   03013 Nucleocytoplasmic transport
    10189 (ALYREF)
   03015 mRNA surveillance pathway
    10189 (ALYREF)
 09160 Human Diseases
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    10189 (ALYREF)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    10189 (ALYREF)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    10189 (ALYREF)
   03041 Spliceosome [BR:hsa03041]
    10189 (ALYREF)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Transport factors
    EJC complex
     10189 (ALYREF)
    TREX complex
     10189 (ALYREF)
Spliceosome [BR:hsa03041]
 Complex C
  Other components
   EJC/TREX
    10189 (ALYREF)
 Other splicing related proteins
  Spliceosome associated proteins (SAPs)
   TREX complex
    10189 (ALYREF)
SSDB
Motif
Pfam: RRM_1 FoP_duplication FYTT RRM_occluded RRM_5
Other DBs
NCBI-GeneID: 10189
NCBI-ProteinID: NP_005773
OMIM: 604171
HGNC: 19071
Ensembl: ENSG00000183684
UniProt: Q86V81 E9PB61
Structure
Position
17:complement(81887835..81891587)
AA seq 264 aa
MPDSAPAMADKMDMSLDDIIKLNRSQRGGRGGGRGRGRAGSQGGRGGGAQAAARVNRGGG
PIRNRPAIARGAAGGGGRNRPAPYSRPKQLPDKWQHDLFDSGFGGGAGVETGGKLLVSNL
DFGVSDADIQELFAEFGTLKKAAVHYDRSGRSLGTADVHFERKADALKAMKQYNGVPLDG
RPMNIQLVTSQIDAQRRPAQSVNRGGMTRNRGAGGFGGGGGTRRGTRGGARGRGRGAGRN
SKQQLSAEELDAQLDAYNARMDTS
NT seq 795 nt   +upstreamnt  +downstreamnt
atgcccgattccgcgcccgccatggccgacaaaatggacatgtctctggacgacatcatt
aaactgaaccggagccagcgaggcggccggggcgggggccggggccgcggccgggccggc
tcccagggcggccgcggcggtggggcgcaggccgccgcgcgagtgaatcgaggcggcggg
cccatccggaaccggccggccatcgcccgcggcgcggccggcggaggcggcaggaaccga
ccggcgccctacagcaggccaaaacaacttcccgacaagtggcagcacgatcttttcgac
agtggcttcggcggtggtgccggcgtggagacaggtgggaaactgctggtgtccaatctg
gattttggagtctcagacgccgatattcaggaactctttgctgaatttggaacgctgaag
aaggcggctgtgcactatgatcgctctggtcgcagcttaggaacagcagacgtgcacttt
gagcggaaggcagatgccctgaaggccatgaagcagtacaacggcgtccctctggatggc
cgccccatgaacattcagcttgtcacgtcacagattgacgcacagcggaggcctgcacag
agcgtaaacagaggtggcatgactagaaaccgtggcgctggaggttttggtggtggtgga
ggcacccggagaggcacccgcggaggcgcccgtggaagaggcagaggtgccggcaggaat
tcaaagcagcagctttcggcagaggagctggatgcccagctggacgcctataatgcgaga
atggacaccagttaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (5)   
   KEGG PATHWAY (5)   
Network (3)   
   KEGG NETWORK (3)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (44)   
   KEGG ORTHOLOGY (1)   
   RefGene (22)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (16)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (10)   
   RefSeq(nuc) (2)   
   GenBank (4)   
   EMBL (4)   
3D Structure (3)   
   PDB (3)   
Protein domain (5)   
   Pfam (5)   
All databases (79)   

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