KEGG T01001: 1021

Homo sapiens (human): 1021

Entry

1021              CDS       T01001

Symbol

CDK6, MCPH12, PLSTIRE

Name

(RefSeq) cyclin dependent kinase 6

K02091

cyclin-dependent kinase 6 [EC:2.7.11.22]

Organism

hsa Homo sapiens (human)

Pathway

hsa04110

Cell cycle

hsa04115

p53 signaling pathway

hsa04151

PI3K-Akt signaling pathway

hsa04218

Cellular senescence

hsa04934

Cushing syndrome

hsa05160

Hepatitis C

hsa05162

Measles

hsa05163

Human cytomegalovirus infection

hsa05164

Influenza A

hsa05165

Human papillomavirus infection

hsa05167

Kaposi sarcoma-associated herpesvirus infection

hsa05169

Epstein-Barr virus infection

hsa05200

Pathways in cancer

hsa05203

Viral carcinogenesis

hsa05206

MicroRNAs in cancer

hsa05212

Pancreatic cancer

hsa05214

Glioma

hsa05218

Melanoma

hsa05220

Chronic myeloid leukemia

hsa05222

Small cell lung cancer

hsa05223

Non-small cell lung cancer

hsa05224

Breast cancer

hsa05225

Hepatocellular carcinoma

Network

nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06170  Influenza A virus (IAV)
nt06230  Cell cycle (cancer)
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06265  Bladder cancer
nt06266  Non-small cell lung cancer
nt06267  Small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06273  Glioma
nt06276  Chronic myeloid leukemia

Element

N00066

MDM2-p21-Cell cycle G1/S

N00067

Deleted p14(ARF) to p21-cell cycle G1/S

N00068

Amplified MDM2 to p21-cell cycle G1/S

N00069

p16-Cell cycle G1/S

N00070

Mutation-inactivated p16(INK4a) to p16-cell cycle G1/S

N00071

Deleted p16(INK4a) to p16-cell cycle G1/S

N00076

Mutation-inactivated p14(ARF) to p21-cell cycle G1/S

N00088

Amplified MYC to p15-cell cycle G1/S

N00089

Amplified MYC to cell cycle G1/S

N00090

p15-Cell cycle G1/S

N00168

KSHV vCyclin to cell cycle G1/S

N00347

p300-p21-Cell cycle G1/S

N00483

EBV EBNA3C to cell cycle G1/S

Disease

H00269

Primary microcephaly

Drug target

Abemaciclib:

D10688<JP/US>

Alvocidib (DG02041):

D02880 D09868

Atirmociclib:

D12834

Lerociclib:

D11455

Palbociclib (DG01831):

D10372<JP/US> D10652

Ribociclib (DG02084):

D10883 D10979<US>

Trilaciclib (DG03146):

D11130 D11987<US>

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    1021 (CDK6)
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    1021 (CDK6)
   04115 p53 signaling pathway
    1021 (CDK6)
   04218 Cellular senescence
    1021 (CDK6)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1021 (CDK6)
   05206 MicroRNAs in cancer
    1021 (CDK6)
   05203 Viral carcinogenesis
    1021 (CDK6)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    1021 (CDK6)
   05225 Hepatocellular carcinoma
    1021 (CDK6)
   05214 Glioma
    1021 (CDK6)
   05220 Chronic myeloid leukemia
    1021 (CDK6)
   05218 Melanoma
    1021 (CDK6)
   05224 Breast cancer
    1021 (CDK6)
   05222 Small cell lung cancer
    1021 (CDK6)
   05223 Non-small cell lung cancer
    1021 (CDK6)
  09172 Infectious disease: viral
   05160 Hepatitis C
    1021 (CDK6)
   05164 Influenza A
    1021 (CDK6)
   05162 Measles
    1021 (CDK6)
   05163 Human cytomegalovirus infection
    1021 (CDK6)
   05167 Kaposi sarcoma-associated herpesvirus infection
    1021 (CDK6)
   05169 Epstein-Barr virus infection
    1021 (CDK6)
   05165 Human papillomavirus infection
    1021 (CDK6)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    1021 (CDK6)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    1021 (CDK6)
Enzymes [BR:hsa01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     1021 (CDK6)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: CMGC group
  CDK family
   1021 (CDK6)

SSDB

Motif

Pfam:

Pkinase PK_Tyr_Ser-Thr ABC1 Kdo APH Haspin_kinase RIO1 Kinase-like FTA2 Uricase

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

7:complement(92604921..92836573)

AA seq 326 aa
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA

NT seq 981 nt +upstreamnt +downstreamnt
atggagaaggacggcctgtgccgcgctgaccagcagtacgaatgcgtggcggagatcggg
gagggcgcctatgggaaggtgttcaaggcccgcgacttgaagaacggaggccgtttcgtg
gcgttgaagcgcgtgcgggtgcagaccggcgaggagggcatgccgctctccaccatccgc
gaggtggcggtgctgaggcacctggagaccttcgagcaccccaacgtggtcaggttgttt
gatgtgtgcacagtgtcacgaacagacagagaaaccaaactaactttagtgtttgaacat
gtcgatcaagacttgaccacttacttggataaagttccagagcctggagtgcccactgaa
accataaaggatatgatgtttcagcttctccgaggtctggactttcttcattcacaccga
gtagtgcatcgcgatctaaaaccacagaacattctggtgaccagcagcggacaaataaaa
ctcgctgacttcggccttgcccgcatctatagtttccagatggctctaacctcagtggtc
gtcacgctgtggtacagagcacccgaagtcttgctccagtccagctacgccacccccgtg
gatctctggagtgttggctgcatatttgcagaaatgtttcgtagaaagcctctttttcgt
ggaagttcagatgttgatcaactaggaaaaatcttggacgtgattggactcccaggagaa
gaagactggcctagagatgttgcccttcccaggcaggcttttcattcaaaatctgcccaa
ccaattgagaagtttgtaacagatatcgatgaactaggcaaagacctacttctgaagtgt
ttgacatttaacccagccaaaagaatatctgcctacagtgccctgtctcacccatacttc
caggacctggaaaggtgcaaagaaaacctggattcccacctgccgcccagccagaacacc
tcggagctgaatacagcctga

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