KEGG   Homo sapiens (human): 10269
Entry
10269             CDS       T01001                                 
Symbol
ZMPSTE24, FACE-1, FACE1, HGPS, PRO1, RSDM1, STE24, Ste24p
Name
(RefSeq) zinc metallopeptidase STE24
  KO
K06013  STE24 endopeptidase [EC:3.4.24.84]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00900  Terpenoid backbone biosynthesis
Disease
H00663  Restrictive dermopathy
H00665  Mandibuloacral dysplasia
H02677  Progeroid laminopathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    10269 (ZMPSTE24)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    10269 (ZMPSTE24)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    10269 (ZMPSTE24)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.84  Ste24 endopeptidase
     10269 (ZMPSTE24)
Peptidases and inhibitors [BR:hsa01002]
 Metallo peptidases
  Family M48: Ste24 endopeptidase family
   10269 (ZMPSTE24)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   10269 (ZMPSTE24)
SSDB
Motif
Pfam: Peptidase_M48_N Peptidase_M48
Other DBs
NCBI-GeneID: 10269
NCBI-ProteinID: NP_005848
OMIM: 606480
HGNC: 12877
Ensembl: ENSG00000084073
UniProt: O75844
Structure
Position
1:40258236..40294180
AA seq 475 aa
MGMWASLDALWEMPAEKRIFGAVLLFSWTVYLWETFLAQRQRRIYKTTTHVPPELGQIMD
SETFEKSRLYQLDKSTFSFWSGLYSETEGTLILLFGGIPYLWRLSGRFCGYAGFGPEYEI
TQSLVFLLLATLFSALTGLPWSLYNTFVIEEKHGFNQQTLGFFMKDAIKKFVVTQCILLP
VSSLLLYIIKIGGDYFFIYAWLFTLVVSLVLVTIYADYIAPLFDKFTPLPEGKLKEEIEV
MAKSIDFPLTKVYVVEGSKRSSHSNAYFYGFFKNKRIVLFDTLLEEYSVLNKDIQEDSGM
EPRNEEEGNSEEIKAKVKNKKQGCKNEEVLAVLGHELGHWKLGHTVKNIIISQMNSFLCF
FLFAVLIGRKELFAAFGFYDSQPTLIGLLIIFQFIFSPYNEVLSFCLTVLSRRFEFQADA
FAKKLGKAKDLYSALIKLNKDNLGFPVSDWLFSMWHYSHPPLLERLQALKTMKQH
NT seq 1428 nt   +upstreamnt  +downstreamnt
atggggatgtgggcatcgctggacgctttgtgggagatgccggccgagaagcgtatcttc
ggggccgtgctgctcttttcctggacagtgtatctttgggagaccttcctagcacagcgg
cagagaaggatatataaaacaacaactcatgtaccaccggagttaggacagatcatggat
tctgaaacatttgagaaatctcgactctatcaactggataaaagcactttcagcttctgg
tcaggactctattcagagactgaaggcactcttattcttctctttggaggaataccttat
ctctggagactttctggacggttctgtggttatgctggctttggaccagaatatgagatc
actcagtccctggtgtttctgctgttggctacacttttcagtgcattgactggtttgcca
tggagtctttataatacttttgtgatagaagaaaaacatggcttcaatcaacagactttg
gggttcttcatgaaagatgcaatcaagaaatttgttgtgactcagtgtattttgttgcct
gtgtcttcacttctactttacattattaaaattgggggtgactatttttttatttatgcc
tggctgttcacattagttgtgtctctggttcttgtcacaatctatgctgattatattgcc
cctttatttgacaaattcacacctctgcctgagggaaagcttaaagaagaaattgaagta
atggcaaagagtattgactttcctttgacgaaggtgtatgttgtggaaggatctaaacgc
tcttcccacagcaatgcttatttttatggcttcttcaagaacaagcgaatagttttgttt
gacactctactagaagagtactctgtactaaacaaagacatccaggaggattctggcatg
gaaccccgcaatgaggaagaagggaacagtgaagaaataaaagctaaagttaaaaataag
aaacaaggatgtaaaaatgaggaggtactcgctgtactaggccatgaactggggcactgg
aagttgggacatacagtcaaaaatatcattattagccagatgaattctttcctgtgtttt
tttttatttgctgtattaattggtcgaaaggagctttttgctgcatttggtttttatgat
agccaacccactcttattggactattgatcatcttccagtttattttttcaccttacaat
gaggttctttctttttgcctaacagtcctaagccgcagatttgagtttcaagctgatgca
tttgccaagaaacttgggaaggctaaagacttatattctgctttaatcaaacttaacaaa
gataacttgggattccctgtttctgactggttgttctcaatgtggcattattctcatcct
ccactgctagagagacttcaagctttgaaaactatgaagcaacactga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (6)   
   KEGG DISEASE (3)   
   OMIM (3)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (29)   
   RefSeq(nuc) (5)   
   GenBank (12)   
   EMBL (12)   
3D Structure (4)   
   PDB (4)   
Protein domain (2)   
   Pfam (2)   
All databases (75)   

Download RDF
DBGET integrated database retrieval system