KEGG   Homo sapiens (human): 10352
Entry
10352             CDS       T01001                                 
Symbol
WARS2, NEMMLAS, PKDYS3, TrpRS, mtTrpRS
Name
(RefSeq) tryptophanyl tRNA synthetase 2, mitochondrial
  KO
K01867  tryptophanyl-tRNA synthetase [EC:6.1.1.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00970  Aminoacyl-tRNA biosynthesis
Disease
H02676  Infantile-onset parkinsonism-dystonia
H02709  Neurodevelopmental disorder with aminoacyl-tRNA synthetase defect
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   00970 Aminoacyl-tRNA biosynthesis
    10352 (WARS2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes [BR:hsa01007]
    10352 (WARS2)
  09182 Protein families: genetic information processing
   03016 Transfer RNA biogenesis [BR:hsa03016]
    10352 (WARS2)
Enzymes [BR:hsa01000]
 6. Ligases
  6.1  Forming carbon-oxygen bonds
   6.1.1  Ligases forming aminoacyl-tRNA and related compounds
    6.1.1.2  tryptophan---tRNA ligase
     10352 (WARS2)
Amino acid related enzymes [BR:hsa01007]
 Aminoacyl-tRNA synthetase
  Class I (G)
   10352 (WARS2)
Transfer RNA biogenesis [BR:hsa03016]
 Eukaryotic type
  Aminoacyl-tRNA synthetases (AARSs)
   Other AARSs
    10352 (WARS2)
 Prokaryotic type
    10352 (WARS2)
SSDB
Motif
Pfam: tRNA-synt_1b DUF2067 SgrT
Other DBs
NCBI-GeneID: 10352
NCBI-ProteinID: NP_056651
OMIM: 604733
HGNC: 12730
Ensembl: ENSG00000116874
UniProt: Q9UGM6
Structure
Position
1:complement(119031216..119140672)
AA seq 360 aa
MALHSMRKARERWSFIRALHKGSAAAPALQKDSKKRVFSGIQPTGILHLGNYLGAIESWV
RLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQQSQVSEH
TQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGE
DQVQHMELVQDLAQGFNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRI
TDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVSNIVAVHAAVTGLSVEEVVRRSAGMNTA
RYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIGSAKAKELAYTVCQEVKKLVGFL
NT seq 1083 nt   +upstreamnt  +downstreamnt
atggcgctgcactcaatgcggaaagcgcgtgagcgctggagcttcatccgggcacttcat
aagggatccgcagctgctcccgctctccagaaagacagcaagaagcgagtattttccggc
attcaacctacaggaatcctccacctgggcaattacctgggagccattgagagctgggtg
aggttacaggatgaatatgactctgtattatacagcattgttgacctccactccattact
gtcccccaagacccagctgtccttcggcagagcatcctggacatgactgctgttcttctt
gcctgtggcataaacccggaaaaaagcatccttttccaacaatctcaggtgtctgaacac
acacaattaagttggatcctttcctgcatggtcagactacctcgattacaacatttacat
cagtggaaggcaaagactaccaagcagaagcacgatggcacggtgggcctgctcacatac
ccagtactccaggcagccgacattctgttgtacaagtccacacacgttcctgttggggag
gatcaagtccagcacatggaactagttcaggatctagcacaaggtttcaacaagaagtat
ggggagttctttccagtgcccgagtccattctcacatccatgaagaaggtaaaatcccta
cgtgatccttctgccaaaatgtcgaaatcagaccctgacaaactggccaccgtccgaata
acagacagcccagaggagatagtgcagaaattccgcaaggctgtgacagacttcacctcg
gaggtcacctatgacccggctggccgcgctggcgtgtccaacatagtggcggtgcatgcc
gcggtgacggggctctccgtggaggaagtggtgcgccgcagcgcgggcatgaacactgct
cgctacaagctggccgtggcagatgctgtgattgagaagtttgccccaattaagcgtgaa
attgaaaaactgaagctggacaaggaccatttagagaaggttttacaaattggatcagca
aaagccaaagaattagcatacactgtgtgccaggaggtgaagaaattggtgggttttcta
tag

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (19)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (17)   
DNA sequence (39)   
   RefSeq(nuc) (17)   
   GenBank (11)   
   EMBL (11)   
3D Structure (1)   
   PDB (1)   
Protein domain (3)   
   Pfam (3)   
All databases (97)   

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