KEGG T01001: 10382

Homo sapiens (human): 10382

Entry

10382             CDS       T01001

Symbol

TUBB4A, DYT4, TUBB4, beta-5

Name

(RefSeq) tubulin beta 4A class IVa

K07375

tubulin beta

Organism

hsa Homo sapiens (human)

Pathway

hsa04145

Phagosome

hsa04540

Gap junction

hsa04814

Motor proteins

hsa05010

Alzheimer disease

hsa05012

Parkinson disease

hsa05014

Amyotrophic lateral sclerosis

hsa05016

Huntington disease

hsa05020

Prion disease

hsa05022

Pathways of neurodegeneration - multiple diseases

hsa05130

Pathogenic Escherichia coli infection

hsa05132

Salmonella infection

Network

nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06515  Regulation of kinetochore-microtubule interactions

Element

N00976

Retrograde axonal transport

N00977

Mutation-caused aberrant Htt to retrograde axonal transport

N00978

Anterograde axonal transport

N00979

Mutation-caused aberrant Htt to anterograde axonal transport

N01018

Mutation-caused aberrant Abeta to anterograde axonal transport

N01055

Mutation-caused aberrant SNCA to anterograde axonal transport

N01158

Mutation-caused aberrant DCTN1 to retrograde axonal transport

N01285

Microtubule-RHOA signaling pathway

N01286

Escherichia EspG to Microtubule-RHOA signaling pathway

N01295

Rab7-regulated microtubule minus-end directed transport

N01297

Arl8-regulated microtubule plus-end directed transport

N01298

Salmonella SifA to microtubule plus-end directed transport

N01299

Salmonella PipB2 to microtubule plus-end directed transport

N01403

Zn to anterograde axonal transport

N01414

Iron to anterograde axonal transport

N01535

Kinetochore microtubule attachment

N01544

Microtubule nucleation

N01547

Kinetochore fiber organization

N01549

Branching microtubule nucleation

N01553

Promotion of microtubule growth

N01561

Microtubule depolymerization

N01562

Microtubule depolymerization at the minus ends

Disease

H00679

Hypomyelinating leukodystrophy

H00831

Primary dystonia

Drug target

Anvatabart opadotin:

D12583

Avanbulin:

D11681

Batabulin (DG01412):

D03059 D06560

Belantamab mafodotin:

D11595<US>

Brentuximab vedotin:

D09587<JP/US>

Cabazitaxel (DG00695):

D09755 D10452<JP/US>

Cantuzumab mertansine:

D03364

Cantuzumab ravtansine:

D10454

Cevipabulin (DG01413):

D06576 D08889

Colchicine:

D00570<JP/US>

Denintuzumab mafodotin:

D11232

Docetaxel (DG00694):

D02165<JP/US> D07866<JP/US>

Enfortumab vedotin:

D11525<JP/US>

Eribulin:

D08914<JP/US>

Estramustine (DG00724):

D02398 D04066 D06397<JP/US>

Farletuzumab ecteribulin:

D12183

Glembatumumab vedotin:

D09912

Indibulin:

D10013

Ixabepilone:

D04645<US>

Lexibulin:

D10073

Lifastuzumab vedotin:

D11238

Lisavanbulin:

D11494

Lorvotuzumab mertansine:

D09927

Maytansine:

D04864

Mecbotamab vedotin:

D12220

Mirvetuximab soravtansine:

D10954<US>

Mivobulin isethionate:

D05062

Opadotin:

D12582

Ozuriftmab vedotin:

D12210

Paclitaxel:

D00491<JP/US>

Paclitaxel poliglumex:

D05333

Sabizabulin (DG03253):

Soblidotin:

Soravtansine:

Taltobulin:

Tasidotin hydrochloride:

D06009

Tirbanibulin (DG03082):

D11691<US> D11692

Tisotumab vedotin:

D11814<US>

Trastuzumab emtansine:

D09980<JP/US>

Tusamitamab ravtansine:

D12310

Vedotin:

D09691

Verubulin (DG01411):

D10029 D10030

Vinblastine (DG00689):

D01068<JP/US> D08675

Vincristine (DG00690):

D02197<JP/US> D08679

Vindesine (DG00691):

D01769<JP> D06304

Vinepidine sulfate:

D06305

Vinflunine:

D09032

Vinglycinate sulfate:

D06306

Vinleurosine sulfate:

D06307

Vinorelbine (DG00692):

D01935<JP/US> D08680

Vinrosidine sulfate:

D06308

Vinzolidine sulfate:

D06309

Brite

KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    10382 (TUBB4A)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    10382 (TUBB4A)
  09142 Cell motility
   04814 Motor proteins
    10382 (TUBB4A)
09160 Human Diseases
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    10382 (TUBB4A)
   05132 Salmonella infection
    10382 (TUBB4A)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    10382 (TUBB4A)
   05012 Parkinson disease
    10382 (TUBB4A)
   05014 Amyotrophic lateral sclerosis
    10382 (TUBB4A)
   05016 Huntington disease
    10382 (TUBB4A)
   05020 Prion disease
    10382 (TUBB4A)
   05022 Pathways of neurodegeneration - multiple diseases
    10382 (TUBB4A)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    10382 (TUBB4A)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    10382 (TUBB4A)
   04147 Exosome [BR:hsa04147]
    10382 (TUBB4A)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
  Centrosome formation proteins
   Microtubules and associated factors
    Other tubulins
     10382 (TUBB4A)
Cytoskeleton proteins [BR:hsa04812]
Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    10382 (TUBB4A)
Exosome [BR:hsa04147]
Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   10382 (TUBB4A)
  Exosomal proteins of colorectal cancer cells
   10382 (TUBB4A)
  Exosomal proteins of bladder cancer cells
   10382 (TUBB4A)

SSDB

Motif

Pfam:

Tubulin Tubulin_C Misat_Tub_SegII Tubulin_3 Tubulin_2

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Position

19:complement(6494319..6502848)

AA seq 444 aa
MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGNYV
PRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDAVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLSVQSKNSSYFVEWIPNNVKTAVCDIPPRG
LKMAATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEGEFEEEAEEEVA

NT seq 1335 nt +upstreamnt +downstreamnt
atgcgggagatcgtgcacctgcaggccggccagtgcggcaaccagatcggggccaagttt
tgggaggttatcagtgacgaacatggcatcgaccccacaggcacataccatggggacagt
gacctgcaactggagaggatcaacgtgtactacaacgaggccacaggaggaaattatgtc
cccagagcggtgctggtggacctggaacccggcaccatggactctgtccgttctggcccc
ttcggtcagatctttcggccggacaacttcgtgtttggccaatccggagccggcaacaac
tgggcaaaggggcactacacggagggcgcagagctggtggacgctgtcctggacgtagtc
cggaaggaggccgagagctgcgactgccttcagggcttccagctgacccactcgctgggg
ggtggcacggggtccggaatgggcacgctgctcatcagtaagatccgcgaggagttccca
gaccgcatcatgaacaccttcagcgtggtgccctcgcccaaagtgtcagacacggtggtg
gagccctacaacgccacgctgtctgtgcaccagctggtggagaatacggatgagacctac
tgcatcgacaacgaggcactctacgacatctgtttccgcaccctcaagctgaccaccccc
acctacggggacctcaaccacctggtgtcggccaccatgagcggggtcaccacctgcctg
cgcttcccgggccagctgaacgccgacctgcgcaagctggccgtcaacatggttcccttt
cctcgcctgcacttcttcatgcccggcttcgcacccctgaccagccggggcagccagcag
taccgggccctgacggtgcccgagctcacccagcagatgttcgatgccaagaacatgatg
gcggcgtgcgacccgcgccacggccgctacctgaccgtggccgccgtgttccggggccgc
atgtccatgaaggaggtggacgagcagatgctgagcgtgcagagcaagaacagcagctac
ttcgtggagtggatccccaacaacgtgaagacggccgtgtgcgacatcccgccccgcggc
ctgaagatggccgcgaccttcatcggcaacagcacggccatccaggagctgttcaagcgc
atctccgagcagttcacggccatgttccggcgcaaggccttcttgcactggtacacgggc
gagggcatggacgagatggagttcaccgaggccgagagcaacatgaatgacctggtatct
gagtaccagcagtaccaggacgccacggccgaggagggcgagttcgaggaggaggcggag
gaggaggtggcctag

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