KEGG   Homo sapiens (human): 10564
Entry
10564             CDS       T01001                                 
Symbol
ARFGEF2, BIG2, PVNH2, dJ1164I10.1
Name
(RefSeq) ADP ribosylation factor guanine nucleotide exchange factor 2
  KO
K18442  brefeldin A-inhibited guanine nucleotide-exchange protein
Organism
hsa  Homo sapiens (human)
Pathway
hsa04144  Endocytosis
Disease
H00270  Periventricular nodular heterotopia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    10564 (ARFGEF2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    10564 (ARFGEF2)
Membrane trafficking [BR:hsa04131]
 Endosome - Golgi transport
  Arf GTPases and associated proteins
   Arf GTPase associated proteins
    10564 (ARFGEF2)
SSDB
Motif
Pfam: Sec7 BIG2_C Sec7-like_HUS DCB Sec7-like_HDS
Other DBs
NCBI-GeneID: 10564
NCBI-ProteinID: NP_006411
OMIM: 605371
HGNC: 15853
Ensembl: ENSG00000124198
UniProt: Q9Y6D5 Q86TH5 Q59FR3
Structure
Position
20:48921711..49036693
AA seq 1785 aa
MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKA
NFIEADKYFLPFELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVE
TICSCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQT
TAKATLTQMLNVIFTRMENQVLQEARELEKPIQSKPQSPVIQAAAVSPKFVRLKHSQAQS
KPTTPEKTDLTNGEHARSDSGKVSTENGDAPRERGSSLSGTDDGAQEVVKDILEDVVTSA
IKEAAEKHGLTEPERVLGELECQECAIPPGVDENSQTNGIADDRQSLSSADNLESDAQGH
QVAARFSHVLQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGP
VFRTHEMFINAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFKE
IFLNILETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKI
AQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQTSLGQERLTDQE
IGDGKGLDMARRCSVTSMESTVSSGTQTTVQDDPEQFEVIKQQKEIIEHGIELFNKKPKR
GIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEK
EFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLT
TDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKETKELTIATK
STKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTP
LLAAYSIGLQNCDDTEVASLCLEGIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSI
TEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKTRYLSGSGRE
REGSLKGHTLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGST
RLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGD
HFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIR
DMAIRCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTTIFQHHF
PAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAP
GDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFEKHWWQDLFRIVFR
IFDNMKLPEQLSEKSEWMTTTCNHALYAICDVFTQFYEALNEVLLSDVFAQLQWCVKQDN
EQLARSGTNCLENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGMEEDSSE
KHLDVDLDRQSLSSIDKNPSERGQSQLSNPTDDSWKGRPYANQKLFASLLIKCVVQLELI
QTIDNIVFYPATSKKEDAEHMVAAQQDTLDADIHIETEDQGMYKYMSSQHLFKLLDCLQE
SHSFSKAFNSNYEQRTVLWRAGFKGKSKPNLLKQETSSLACCLRILFRMYVDENRRDSWE
EIQQRLLTVCSEALAYFITVNSESHREAWTSLLLLLLTKTLKINDEKFKAHASMYYPYLC
EIMQFDLIPELRAVLRKFFLRIGVVYKIWIPEEPSQVPAALSPVW
NT seq 5358 nt   +upstreamnt  +downstreamnt
atgcaggagagccagaccaagagcatgttcgtgtcccgggccctggagaagatcctagcc
gacaaggaggtgaagcggccccagcactcccagctgcgcagggcctgccaggtggcgctc
gatgaaattaaagcagaaatagaaaagcagaggcttggcactgctgcaccaccaaaggca
aacttcattgaagctgacaagtattttcttccattcgagctagcttgccagtccaagtcc
ccaagggtagtcagcacatcccttgactgcttgcagaaactcatcgcatacgggcacatc
actggcaacgcccctgacagtggagcccctgggaagcggctgatcgacagaattgttgaa
accatttgcagttgttttcagggccctcagactgatgaaggggttcagttacaaataatt
aaggctcttctgactgcagtgacttccccacacattgaaattcatgagggtactatcctg
cagacagtgagaacatgttacaatatctatttggccagcaaaaatctcatcaatcaaacc
actgccaaggctacccttactcagatgctgaacgtcattttcacccgcatggaaaaccaa
gtgttgcaggaggccagagaactggaaaaaccaatccagtcaaaaccccagtcccctgtg
atccaagctgcagcagtatccccaaagttcgttcgtttgaagcacagtcaggcacaaagc
aaaccaacaactcccgaaaaaacagatttaaccaacggtgaacatgccaggagtgattct
ggaaaagtaagcacagaaaatggagacgcacccagagaaagaggctcatcactgtcaggg
actgatgacggagcccaggaggtggtgaaggacatcttggaagatgtagtcacatctgcc
attaaagaagcagcggaaaagcatggtctgacagaacctgagagagttctaggtgaactg
gagtgccaggaatgtgctattcccccaggagttgatgaaaactcacagaccaacgggata
gccgatgacaggcagtccttgtcgtcagcagataatctggaatcggatgcacaaggacat
caagtggctgccaggttctcccacgttctgcagaaggatgccttccttgtgttccgctcc
ctgtgcaagctgtccatgaaaccccttggtgaaggccctccagacccaaaatcccatgag
ctgcgttccaaggtggtttccctgcagctgctcctctctgtgttgcaaaatgctggcccc
gtattcaggactcacgagatgttcatcaatgcaatcaagcaatatctctgtgtggccttg
tccaaaaacggcgtctcttcagtgcctgatgtctttgagctctctcttgccatttttctt
actcttctttcaaactttaaaatgcacttgaaaatgcagatagaggtctttttcaaagag
attttcctgaacattttagaaacatcaacaagttcttttgagcacaggtggatggtcatt
cagactctgacgaggatctgtgcagatgcccagtgtgttgtggatatttatgtcaactac
gactgtgatttaaatgctgctaacatttttgagcgccttgtaaatgatttatccaaaatt
gctcagggaagaagtggacatgagctgggaatgacacctctgcaggagctcagcctgagg
aagaaaggcctggagtgcctcgtgtccattctcaagtgcatggtggagtggagcaaagac
ctgtatgtgaatcccaaccaccagaccagcctcggtcaggagaggctcacggatcaggaa
ataggggatgggaaaggccttgacatggcaagacggtgtagtgtgacgtccatggagtcc
acagtgtcctcggggacccagacaactgttcaggatgaccctgagcaatttgaggtcatc
aagcaacaaaaagaaatcattgaacacggcatcgagctgttcaacaagaaacccaagagg
gggatccagtttctccaggagcagggcatgctgggaacgtcagttgaagacatagcccaa
ttcctgcaccaggaggagcgcctggattccacccaagtaggcgattttctgggagatagc
gcaaggttcaacaaggaggtgatgtatgcctacgtggaccaacttgacttctgtgaaaaa
gaatttgtctcagccctgcggacattcctagaaggtttccgcctacctggagaagcccaa
aagattgaccgattaatggagaagtttgccgcaagatacatagaatgcaaccaagggcaa
actctgtttgctagtgctgacactgcttatgtcctagcgtattcaattattatgctgact
acagacttgcacagtcctcaggtaaaaaataaaatgacgaaagagcagtatattaaaatg
aatcggggtatcaatgatagtaaagatctgccagaagagtatctctcaagcatctatgaa
gagatagaaggcaagaaaattgcaatgaaagaaacaaaagagctaacgattgcaaccaaa
tctactaagcagaatgtagctagtgaaaagcagcggcggctgctgtacaacttagagatg
gagcaaatggctaaaacagccaaagctctgatggaggctgtgagccatgccaaagccccg
tttaccagtgccactcacctggaccatgtccggccaatgttcaaactggtgtggacgcca
ctattggcagcctacagcatcggactccagaactgtgatgacactgaagtggcctccttg
tgtttggaaggcatccgatgtgcaatccgaatcgcctgcatctttggaatgcagctggaa
cgagatgcctatgttcaggctcttgctcgcttctccctactcacagccagctccagcatc
acagaaatgaagcagaaaaacatcgacaccattaagacgcttatcacagtggctcacacc
gatggcaactaccttgggaattcctggcatgagatcttgaaatgcatcagccagctggag
ctcgctcagctgataggaaccggtgtgaagacgcgctacctgtctggatctgggcgtgaa
agagaagggagcctgaagggccacacattggcaggagaagagttcatgggccttggcctc
ggtaatttggtgagtggcggagtggataaaagacagatggccagcttccaagaatcggtt
ggtgagaccagctcgcagagtgtggttgtagctgtggacaggatttttactgggtctacc
agactggatggaaatgcaatagttgactttgtccgctggctgtgtgctgtgtccatggat
gaactggcttccccccaccatcctcgcatgttcagcttgcagaagattgtggagatatca
tactacaacatgaatcggatccgactacagtggtctcgaatatggcatgtgattggagat
cacttcaataaggttggctgcaaccctaatgaagatgtggctatctttgctgttgactca
ttaaggcaactctccatgaagtttcttgagaagggtgaattagccaacttccgtttccag
aaagattttctgaggccctttgagcatattatgaagaaaaacaggtctcccaccatccgg
gacatggcgatccgctgcattgcccagatggtgaactcccaggcggccaacatccgctca
ggttggaagaacatctttgccgtgttccaccaggcagcctctgatcatgatgggaacatt
gtggagctggccttccagaccacttgccacattgtcacaactattttccagcaccatttt
cctgcagccatcgattcctttcaggatgctgtgaagtgcttatcagagttcgcctgcaac
gccgctttccctgacacgagcatggaagcgattcggctcatccgcttctgtggcaaatac
gtctctgagaggcctcgggtgctacaagaatacacaagtgatgacatgaatgtagctcct
ggtgacagagtctgggtccgaggctggttccccatcttattcgaactctcctgcatcatt
aatagatgcaagttagatgtacgaacaaggggactcacagtcatgtttgagatcatgaag
agctatggccacacctttgaaaagcactggtggcaggacctgttcagaatcgtgtttcgg
atttttgacaatatgaaactccctgagcaactgtcagagaaatctgagtggatgacaaca
acctgcaatcacgcactttatgctatttgtgatgtttttacccagttttatgaagctttg
aatgaagttcttctttctgatgtatttgcacaattgcagtggtgtgtcaaacaagataat
gaacagttggcgcgatcaggtacaaattgcttagaaaacttagtaatatccaatggagag
aaattcagtcctgaagtctgggatgaaacctgcaactgtatgttggatattttcaaaaca
accatcccacatgttttgctgacatggagacctgtaggaatggaggaagattcatcagaa
aagcatttggatgtggatctggaccgccagtctttaagcagcatagataaaaatccctct
gagaggggacagagccagctctctaacccaacagatgacagctggaagggtagaccatac
gcaaatcagaaactgtttgccagcctcctcatcaagtgtgtggtccagttggaattgata
cagaccattgacaacattgtgttctaccctgcgacgagcaaaaaggaggatgcagagcac
atggttgccgcccagcaagacacgctggatgcagatatccacatagagacggaggatcag
ggcatgtataagtacatgtcttcccagcacctcttcaagctgttggactgtttgcaggaa
tcccattcattctcaaaggccttcaactccaattacgagcagcggactgtcctgtggcga
gcaggttttaagggcaagtctaaacccaatcttctaaaacaagaaaccagcagcctggcc
tgttgtttgaggatcctgtttcgaatgtatgttgatgagaaccgcagggattcctgggaa
gaaatacagcagagacttttaactgtttgcagtgaagctcttgcctatttcatcactgtg
aattctgagagccatcgggaggcctggacaagtctcttgttgttacttctaactaaaacc
ctcaaaataaatgatgaaaagttcaaagcacatgcttcaatgtactacccctacttgtgt
gaaattatgcagtttgacctgatccctgagctccgagcagttctgcggaagttcttccta
cggataggtgttgtgtataagatatggataccagaagagccatcacaggtaccagcagca
ctgtcaccagtgtggtag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (8)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (20)   
   RefSeq(nuc) (4)   
   GenBank (8)   
   EMBL (8)   
3D Structure (2)   
   PDB (2)   
Protein domain (5)   
   Pfam (5)   
All databases (62)   

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