KEGG   Homo sapiens (human): 10565
Entry
10565             CDS       T01001                                 
Symbol
ARFGEF1, ARFGEP1, BIG1, DEDISB, P200
Name
(RefSeq) ADP ribosylation factor guanine nucleotide exchange factor 1
  KO
K18442  brefeldin A-inhibited guanine nucleotide-exchange protein
Organism
hsa  Homo sapiens (human)
Pathway
hsa04144  Endocytosis
Disease
H02685  Developmental delay with neuropsychiatric disorders
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    10565 (ARFGEF1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    10565 (ARFGEF1)
Membrane trafficking [BR:hsa04131]
 Endosome - Golgi transport
  Arf GTPases and associated proteins
   Arf GTPase associated proteins
    10565 (ARFGEF1)
SSDB
Motif
Pfam: Sec7 BIG2_C Sec7-like_HUS DCB Sec7-like_HDS
Other DBs
NCBI-GeneID: 10565
NCBI-ProteinID: NP_006412
OMIM: 604141
HGNC: 15772
Ensembl: ENSG00000066777
UniProt: Q9Y6D6
Structure
Position
8:complement(67173511..67343781)
AA seq 1849 aa
MYEGKKTKNMFLTRALEKILADKEVKKAHHSQLRKACEVALEEIKAETEKQSPPHGEAKA
GSSTLPPVKSKTNFIEADKYFLPFELACQSKCPRIVSTSLDCLQKLIAYGHLTGNAPDST
TPGKKLIDRIIETICGCFQGPQTDEGVQLQIIKALLTAVTSQHIEIHEGTVLQAVRTCYN
IYLASKNLINQTTAKATLTQMLNVIFARMENQALQEAKQMEKERHRQHHHLLQSPVSHHE
PESPQLRYLPPQTVDHISQEHEGDLDLHTNDVDKSLQDDTEPENGSDISSAENEQTEADQ
ATAAETLSKNEVLYDGENHDCEEKPQDIVQNIVEEMVNIVVGDMGEGTTINASADGNIGT
IEDGSDSENIQANGIPGTPISVAYTPSLPDDRLSVSSNDTQESGNSSGPSPGAKFSHILQ
KDAFLVFRSLCKLSMKPLSDGPPDPKSHELRSKILSLQLLLSILQNAGPIFRTNEMFINA
IKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILETSTS
SFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELGM
SNVQELSLRKKGLECLVSILKCMVEWSKDQYVNPNSQTTLGQEKPSEQEMSEIKHPETIN
RYGSLNSLESTSSSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYL
QEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSA
LRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHS
PQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKELTIPTKSSKQN
VASEKQRRLLYNLEMEQMAKTAKALMEAVSHVQAPFTSATHLEHVRPMFKLAWTPFLAAF
SVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTVSSGITEMKQ
KNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKPRYISGTVRGREGSL
TGTKDQAPDEFVGLGLVGGNVDWKQIASIQESIGETSSQSVVVAVDRIFTGSTRLDGNAI
VDFVRWLCAVSMDELLSTTHPRMFSLQKIVEISYYNMGRIRLQWSRIWEVIGDHFNKVGC
NPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKRNRSPTIRDMVVRCI
AQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQTTGHIVTLVFEKHFPATIDSF
QDAVKCLSEFACNAAFPDTSMEAIRLIRHCAKYVSDRPQAFKEYTSDDMNVAPEDRVWVR
GWFPILFELSCIINRCKLDVRTRGLTVMFEIMKTYGHTYEKHWWQDLFRIVFRIFDNMKL
PEQQTEKAEWMTTTCNHALYAICDVFTQYLEVLSDVLLDDIFAQLYWCVQQDNEQLARSG
TNCLENVVILNGEKFTLEIWDKTCNCTLDIFKTTIPHALLTWRPNSGETAPPPPSPVSEK
PLDTISQKSVDIHDSIQPRSVDNRPQAPLVSASAVNEEVSKIKSTAKFPEQKLFAALLIK
CVVQLELIQTIDNIVFFPATSKKEDAENLAAAQRDAVDFDVRVDTQDQGMYRFLTSQQLF
KLLDCLLESHRFAKAFNSNNEQRTALWKAGFKGKSKPNLLKQETSSLACGLRILFRMYMD
ESRVSAWEEVQQRLLNVCSEALSYFLTLTSESHREAWTNLLLLFLTKVLKISDNRFKAHA
SFYYPLLCEIMQFDLIPELRAVLRRFFLRIGVVFQISQPPEQELGINKQ
NT seq 5550 nt   +upstreamnt  +downstreamnt
atgtatgaggggaagaagacgaagaacatgttcctgacccgggctctggagaagatattg
gccgacaaggaagtgaagaaggcgcatcactcccagctgcgcaaagcttgcgaggtggcg
ttagaggaaataaaagcggaaactgaaaaacagagtcctcctcatggagaagcaaaagct
ggatcaagcacccttccaccagtgaaatcaaagacaaattttattgaagcagacaagtac
ttcttgccttttgagttggcatgccagtccaaatgtcctcgcatagttagtacatctcta
gattgcttacagaaacttattgcttatgggcacttgactggcaatgctccagatagtaca
acaccaggcaaaaaattaattgatagaattattgaaacaatatgtggctgctttcagggc
cctcagacagatgaaggagttcagctgcagataataaaggctttacttactgcagtaaca
tcacaacacatagaaattcatgaagggactgtactgcaagctgtgagaacatgttacaat
atctacttagcaagcaaaaatctcatcaatcagacaacagccaaagctactctcactcag
atgctaaatgttatctttgcacgcatggaaaaccaagcattacaggaagcaaaacaaatg
gaaaaagaaaggcatcggcagcatcatcatctgttacagtctccagtaagccatcacgag
cctgaatcacctcaacttagatatttgccacctcagactgttgatcatatatcccaagaa
cacgaaggggaccttgacctccatacaaatgatgtagataaaagtcttcaggatgacaca
gagcctgaaaatggatctgatatttccagtgcagaaaatgaacagactgaagctgatcag
gcaactgcagctgaaacattatctaaaaatgaagtgttatatgacggagaaaaccatgat
tgtgaggaaaagccacaagacattgtacagaacattgtagaagaaatggtgaacattgtt
gttggagatatgggagaagggactactataaatgcaagtgcagatggcaacattggaact
atagaggatggtagtgacagtgaaaatattcaagcaaatggaattccaggaacaccaatt
tctgttgcatatacaccatccttacctgatgatagattgtcagtctcttccaatgatact
caggaatctggaaattcttcaggaccttcacctggtgctaagttttcccacattttacaa
aaggatgcctttctagtattcaggtcattgtgtaaactgtcaatgaaaccactgtcagat
ggaccaccagatccaaagtctcatgaactacgatccaagattctttcattgcagttactt
ctatccattctgcagaatgcaggacctattttcaggacaaatgagatgtttattaatgct
attaagcagtatctttgtgttgcactctcaaaaaatggagtctcatctgttccagaggtt
tttgagctttctctttctatatttcttactttgttgtcaaatttcaagacacatctgaag
atgcaaattgaggtgttctttaaagaaattttcttatacattttggaaacttctaccagc
tcatttgatcacaaatggatggttattcagacactgacgaggatttgtgcagatgctcag
agtgtagtggatatttatgtaaactatgactgtgacttaaatgcagccaatatatttgaa
agactagtaaatgatctatcaaaaattgctcaaggaaggggcagtcaagaacttggtatg
agtaatgttcaggaattgagcctgaggaaaaaaggtttagaatgcttagtgtcgattttg
aagtgtatggttgaatggagtaaggatcagtatgtgaatcccaactcccagacaactctt
ggtcaggaaaaaccctcagagcaagagatgagtgaaatcaaacaccctgagacaataaac
agatacggaagtttaaattccctggagtcaacatcatcatcaggaataggcagctacagt
acacagatgtctggcactgataatccagaacaatttgaggtcctaaagcaacaaaaagaa
ataatagaacaagggatagatttatttaataagaaaccaaagagaggaatacagtacctc
caagaacaagggatgcttggcaccacacctgaagatattgcccaattcttacatcaagag
gaaagattagactctactcaagtgggtgagttcctgggagataatgataaatttaacaaa
gaagtcatgtatgcatatgtggaccaacatgacttttcaggaaaagacttcgtttcagcc
cttcgtatgtttctagaaggatttcgtcttccaggggaagctcagaaaatcgatcgatta
atggaaaaatttgctgcaagatacctagaatgcaaccaaggacaaactctctttgctagt
gcggatacagcttatgttttggcttattcaattatcatgttgaccacagaccttcacagt
ccacaggtgaaaaataaaatgacaaaggaacaatacattaagatgaatagaggtatcaat
gacagtaaagaccttcctgaagagtatctatcagccatctataatgaaatagctgggaaa
aagatatcaatgaaagaaacaaaagaactaacaatccctacaaaatcaagtaaacagaat
gtagccagtgaaaaacaaagaagacttctgtataacttagaaatggagcagatggccaag
acagctaaagcactcatggaggccgtgagccatgttcaggcaccctttacaagtgcaaca
catttggagcatgtgaggcccatgtttaagttggcttggacgccttttctggctgcattc
agtgtgggtctacaagattgtgatgatactgaagtagcctctctttgcctggaaggtata
agatgtgcaatcagaattgcatgcattttcagcattcagctggagagagatgcatatgtc
caggcactagcaagatttaccttactcacagtgagttccggtattactgaaatgaaacag
aagaacattgacacaataaaaacacttatcacagtggctcatacagatggaaattattta
ggaaattcatggcatgagattctgaagtgcatcagtcagttggagctggcacagcttata
ggaactggagtgaaacctcgatacatttctggaacagtgcgaggcagagaaggatctctt
actggaacaaaagatcaggctcctgatgaatttgtgggtttagggctagttggaggaaat
gtggactggaaacagatagcaagtattcaggaatccattggagaaaccagttctcagagt
gttgttgttgctgtagatagaatattcacaggatctacaaggctagatggaaatgccatt
gtggattttgtccgttggctctgtgctgtgtctatggatgaattactttccacgacacac
ccaagaatgtttagtctacaaaaaatagtagaaatatcatattacaacatgggaagaata
agattacagtggtctcgaatttgggaagttattggagatcattttaataaggttgggtgt
aatcctaatgaagatgtagctatttttgcagtagactccttgaggcagttgtcaatgaag
ttcttagagaaaggggagcttgctaacttcagattccagaaggatttcttaagacctttt
gaacatataatgaaacggaacaggtctccaacaattcgagatatggttgtacggtgtata
gcacagatggttaattctcaagctgctaacattcgatctggatggaagaacattttctct
gtatttcatctagctgcatctgatcaagatgaaagcatagtggaacttgcattccaaaca
accgggcacattgtcacccttgtatttgaaaaacactttccagcgaccattgattctttc
caggatgcagtgaagtgtttgtctgaatttgcgtgcaatgcagctttcccagacacaagt
atggaagcaattcgacttattcgccattgtgcaaaatatgtgtctgatagacctcaggct
ttcaaggaatacacaagcgatgatatgaacgtagcacctgaagacagggtgtgggtgaga
ggatggttcccaattctctttgagttatcctgtatcatcaatagatgcaaattagatgta
agaaccaggggtttaacagtaatgtttgaaataatgaaaacatatggccacacttatgag
aaacactggtggcaggatttatttagaattgttttcagaatctttgacaatatgaaattg
ccagaacaacagacagagaaagctgaatggatgacaacaacttgcaatcatgcactttat
gcaatctgtgatgtattcactcagtatttagaagtactcagtgatgtacttttggatgac
atttttgctcagctctactggtgtgtgcagcaagacaatgagcagttagcgcgatctggt
acaaactgtttagagaatgttgttattctgaatggtgaaaaatttaccctagaaatctgg
gataaaacttgcaactgcacactggatatcttcaaaaccacaatcccacatgcgctgttg
acctggcgacccaattctggagaaactgcccccccacctccatctcctgtaagtgaaaag
ccattggatacaatatcacagaagtctgtagatattcatgattctattcaaccaaggtct
gtggataacagaccacaagcaccactggtttctgcgtctgctgttaatgaagaagtcagc
aaaattaaatctacagcaaaatttccagaacaaaaattgtttgctgccctgttgattaaa
tgtgttgtgcagctggaactcatccagactatcgacaacattgtcttcttcccagccaca
agtaagaaagaagatgcagaaaacttagctgcagcacagagagatgcggtggactttgat
gttcgcgttgatactcaagaccaaggaatgtaccgctttttaacatcacaacaacttttt
aagctactggactgcttattagagtcacatagatttgcaaaagcgtttaattccaacaac
gaacagaggactgccctgtggaaagcaggattcaaaggcaaatccaagcccaaccttctg
aagcaggagaccagcagcctggcctgtgggctgcgcattctcttccggatgtacatggat
gagagccgcgttagtgcctgggaggaggtccagcagaggcttttgaatgtctgcagtgaa
gcactaagttacttcctcactctaacatcagaaagtcatcgagaagcctggactaactta
ctgcttttgtttctaactaaagttctaaagataagtgataataggtttaaagctcatgca
tcattctactaccctctcttatgtgaaattatgcaatttgacttgattcctgaacttcgt
gctgttcttagaagattttttctgcgaatcggagtagtttttcagatatcacaaccacct
gaacaggaacttggaataaacaagcaatga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   RefGene (16)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (19)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (17)   
DNA sequence (46)   
   RefSeq(nuc) (18)   
   GenBank (14)   
   EMBL (14)   
3D Structure (3)   
   PDB (3)   
Protein domain (5)   
   Pfam (5)   
All databases (102)   

Download RDF
DBGET integrated database retrieval system