KEGG   Homo sapiens (human): 10587
Entry
10587             CDS       T01001                                 
Symbol
TXNRD2, GCCD5, SELZ, TR, TR-BETA, TR3, TRXR2, TXNR2
Name
(RefSeq) thioredoxin reductase 2
  KO
K22182  thioredoxin reductase (NADPH) [EC:1.8.1.9]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00450  Selenocompound metabolism
hsa05200  Pathways in cancer
hsa05225  Hepatocellular carcinoma
Disease
H00256  Familial glucocorticoid deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00450 Selenocompound metabolism
    10587 (TXNRD2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    10587 (TXNRD2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    10587 (TXNRD2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.1  With NAD+ or NADP+ as acceptor
    1.8.1.9  thioredoxin-disulfide reductase
     10587 (TXNRD2)
SSDB
Motif
Pfam: Pyr_redox_2 Pyr_redox_dim Pyr_redox Pyr_redox_3 FAD_binding_2 DAO AlaDh_PNT_C FAD_oxidored HI0933_like GIDA NAD_binding_8 Lys_Orn_oxgnase Thi4 Lycopene_cycl FAD_binding_3
Other DBs
NCBI-GeneID: 10587
NCBI-ProteinID: NP_006431
OMIM: 606448
HGNC: 18155
Ensembl: ENSG00000184470
UniProt: Q9NNW7
Position
22:complement(19875522..19941818)
AA seq 524 aa
MAAMAVALRGLGGRFRWRTQAVAGGVRGAARGAAAGQRDYDLLVVGGGSGGLACAKEAAQ
LGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQAALLGGLIQDAPNYGWEVAQP
VPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVDEHTVCGVAKGGKEILLS
ADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFLTGI
GLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTWEDST
TGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTSPDTQKILVDSREATSVPHIYAIGDV
VEGRPELTPIAIMAGRLLVQRLFGGSSDLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHG
QEHVEVYHAHYKPLEFTVAGRDASQCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALG
IKCGASYAQVMRTVGIHPTCSEEVVKLRISKRSGLDPTVTGCUG
NT seq 1575 nt   +upstreamnt  +downstreamnt
atggcggcaatggcggtggcgctgcggggattaggagggcgcttccggtggcggacgcag
gccgtggcgggcggggtgcggggcgcggcgcggggcgcagcagcaggtcagcgggactat
gatctcctggtggtcggcgggggatctggtggcctggcttgtgccaaggaggccgcccag
ctgggaaggaaggtggccgtggtggactacgtggaaccttctccccaaggcacccggtgg
ggcctcggcggcacctgcgtcaacgtgggctgcatccccaagaagctgatgcaccaggcg
gcactgctgggaggcctgatccaagatgcccccaactatggctgggaggtggcccagccc
gtgccgcatgactggaggaagatggcagaagctgttcaaaatcacgtgaaatccttgaac
tggggccaccgtgtccagcttcaggacagaaaagtcaagtactttaacatcaaagccagc
tttgttgacgagcacacggtttgcggcgttgccaaaggtgggaaagagattctgctgtca
gccgatcacatcatcattgctactggagggcggccgagataccccacgcacatcgaaggt
gccttggaatatggaatcacaagtgatgacatcttctggctgaaggaatcccctggaaaa
acgttggtggtcggggccagctatgtggccctggagtgtgctggcttcctcaccgggatt
gggctggacaccaccatcatgatgcgcagcatccccctccgcggcttcgaccagcaaatg
tcctccatggtcatagagcacatggcatctcatggcacccggttcctgaggggctgtgcc
ccctcgcgggtcaggaggctccctgatggccagctgcaggtcacctgggaggacagcacc
accggcaaggaggacacgggcacctttgacaccgtcctgtgggccataggtcgagtccca
gacaccagaagtctgaatttggagaaggctggggtagatactagccccgacactcagaag
atcctggtggactcccgggaagccacctctgtgccccacatctacgccattggtgacgtg
gtggaggggcggcctgagctgacacccatagcgatcatggccgggaggctcctggtgcag
cggctcttcggcgggtcctcagatctgatggactacgacaatgttcccacgaccgtcttc
accccgctggagtatggctgtgtggggctgtccgaggaggaggcagtggctcgccacggg
caggagcatgttgaggtctatcacgcccattataaaccactggagttcacggtggctgga
cgagatgcatcccagtgttatgtaaagatggtgtgcctgagggagcccccacagctggtg
ctgggcctgcatttccttggccccaacgcaggcgaagttactcaaggatttgctctgggg
atcaagtgtggggcttcctatgcgcaggtgatgcggaccgtgggtatccatcccacatgc
tctgaggaggtagtcaagctgcgcatctccaagcgctcaggcctggaccccacggtgaca
ggctgctgagggtaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (53)   
   RefSeq(nuc) (9)   
   GenBank (22)   
   EMBL (22)   
Protein domain (15)   
   Pfam (15)   
All databases (112)   

Download RDF
DBGET integrated database retrieval system