KEGG   Homo sapiens (human): 10606
Entry
10606             CDS       T01001                                 
Symbol
PAICS, ADE2, ADE2H1, AIRC, PAICSD, PAIS
Name
(RefSeq) phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  KO
K01587  phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:4.1.1.21 6.3.2.6]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00230  Purine metabolism
hsa01100  Metabolic pathways
Module
hsa_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    10606 (PAICS)
Enzymes [BR:hsa01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.21  phosphoribosylaminoimidazole carboxylase
     10606 (PAICS)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.6  phosphoribosylaminoimidazolesuccinocarboxamide synthase
     10606 (PAICS)
SSDB
Motif
Pfam: SAICAR_synt AIRC VCD
Other DBs
NCBI-GeneID: 10606
NCBI-ProteinID: NP_001072992
OMIM: 172439
HGNC: 8587
Ensembl: ENSG00000128050
UniProt: P22234
Structure
Position
4:56410507..56464578
AA seq 425 aa
MATAEVLNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKI
TSCIFQLLQEAGIKTAFTRKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYK
FYPPKVELFFKDDANNDPQWSEEQLIAAKFCFAGLLIGQTEVDIMSHATQAIFEILEKSW
LPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPE
GLQMVKKNFEWVAERVELLLKSESQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVT
SAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPLTPDWGVQ
DVWSSLRLPSGLGCSTVLSPEGSAQFAAQIFGLSNHLVWSKLRASILNTWISLKQADKKI
RECNL
NT seq 1278 nt   +upstreamnt  +downstreamnt
atggcgacagctgaggtactgaacattggtaaaaaattatatgagggtaaaacaaaagaa
gtctacgaattgttagacagtccaggaaaagtcctcctgcagtccaaggaccagattaca
gcaggaaatgcagctagaaaaaaccacctggaaggaaaagctgcaatctcaaataaaatc
accagttgtatttttcagttattacaggaagcaggtattaaaactgccttcaccagaaaa
tgtggggagacagctttcattgcaccgcagtgtgaaatgattccaattgaatgggtttgc
agaagaatagcaactggttcttttctcaaaagaaatcctggtgtcaaggaaggatataag
ttttacccacctaaagtggagttgtttttcaaggatgatgccaataatgacccacagtgg
tctgaggaacagctgattgctgcaaaattttgctttgctggacttcttataggccagact
gaagtggatatcatgagtcatgctacacaggctatatttgaaatactggagaaatcctgg
ttgccccagaattgtacactggttgatatgaagattgaatttggtgttgatgtaaccacc
aaagaaattgttcttgctgatgttattgacaatgattcctggagactctggccatcagga
gatcgaagccaacagaaagacaaacagtcttatcgggacctcaaagaagtaactcctgaa
gggctccaaatggtaaagaaaaactttgagtgggttgcagagagagtagagttgcttttg
aaatcagaaagtcagtgcagggttgtagtgttgatgggctctacttctgatcttggtcac
tgtgaaaaaatcaagaaggcctgtggaaattttggcattccatgtgaacttcgagtaaca
tctgcgcataaaggaccagatgaaactctgaggattaaagctgagtatgaaggggatggc
attcctactgtatttgtggcagtggcaggcagaagtaatggtttgggaccagtgatgtct
gggaacactgcatatccagttatcagctgtcctcccctcacaccagactggggagttcag
gatgtgtggtcttctcttcgactacccagtggtcttggctgttcaaccgtactttctcca
gaaggatcagctcaatttgctgctcagatatttgggttaagcaaccatttggtatggagc
aaactgcgagcaagcattttgaacacatggatttccttgaagcaggctgacaagaaaatc
agagaatgtaatttataa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (2)   
   KEGG MODULE (1)   
Disease (2)   
   OMIM (2)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG ENZYME (2)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (34)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (23)   
   OC (1)   
Protein sequence (16)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (14)   
DNA sequence (46)   
   RefSeq(nuc) (14)   
   GenBank (16)   
   EMBL (16)   
3D Structure (4)   
   PDB (4)   
Protein domain (3)   
   Pfam (3)   
All databases (123)   

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