KEGG   Homo sapiens (human): 10681
Entry
10681             CDS       T01001                                 
Symbol
GNB5, GB5, HG2E, IDDCA, LADCI, LDMLS1, LDMLS2, gbeta5
Name
(RefSeq) G protein subunit beta 5
  KO
K04539  guanine nucleotide-binding protein subunit beta-5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04062  Chemokine signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04371  Apelin signaling pathway
hsa04713  Circadian entrainment
hsa04723  Retrograde endocannabinoid signaling
hsa04724  Glutamatergic synapse
hsa04725  Cholinergic synapse
hsa04726  Serotonergic synapse
hsa04727  GABAergic synapse
hsa04728  Dopaminergic synapse
hsa04926  Relaxin signaling pathway
hsa05032  Morphine addiction
hsa05034  Alcoholism
hsa05163  Human cytomegalovirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06167  Human cytomegalovirus (HCMV)
nt06224  CXCR signaling (cancer)
nt06530  PI3K signaling
nt06533  Chemokine signaling
  Element
N00152  CXCR-GNB/G-ERK signaling pathway
N00153  CCR/CXCR-GNB/G-PI3K-RAC signaling pathway
N00154  CXCR-GNB/G-PI3K-AKT signaling pathway
N00157  KSHV vGPCR to GNB/G-ERK signaling pathway
N00158  KSHV vGPCR to GNB/G-PI3K-AKT signaling pathway
N00178  KSHV vGPCR to GNB/G-PI3K-JNK signaling pathway
N00399  CCR2-GNB/G-PI3K-NFKB signaling pathway
N00400  HCMV US28 to GNB/G-PI3K-NFKB signaling pathway
N00408  LPAR-GNB/G-Rho signaling pathway
N00409  HCMV UL33 to GNB/G-Rho signaling pathway
N00413  CXCR4-GNB/G-PLCB-PKC signaling pathway
N00428  CCR5-GNB/G-PLCB/G-PKC signaling pathway
N00433  CXCR4-GNB/G-RAC signaling pathway
N00434  HIV gp120 to CXCR4-GNB/G-RAC signaling pathway
N01657  GPCR-PI3K signaling pathway
N01746  CCR/CXCR-GNB/G-PI3K signaling pathway
N01769  CCR5-GNB/G-PLCB/G signaling pathway
N01770  CCR2-GNB/G-PI3K signaling pathway
N01771  CXCR4-GNB/G signaling pathway
Disease
H02463  Syndromic intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    10681 (GNB5)
   04371 Apelin signaling pathway
    10681 (GNB5)
   04151 PI3K-Akt signaling pathway
    10681 (GNB5)
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    10681 (GNB5)
  09152 Endocrine system
   04926 Relaxin signaling pathway
    10681 (GNB5)
  09156 Nervous system
   04724 Glutamatergic synapse
    10681 (GNB5)
   04727 GABAergic synapse
    10681 (GNB5)
   04725 Cholinergic synapse
    10681 (GNB5)
   04728 Dopaminergic synapse
    10681 (GNB5)
   04726 Serotonergic synapse
    10681 (GNB5)
   04723 Retrograde endocannabinoid signaling
    10681 (GNB5)
  09159 Environmental adaptation
   04713 Circadian entrainment
    10681 (GNB5)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    10681 (GNB5)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    10681 (GNB5)
   05163 Human cytomegalovirus infection
    10681 (GNB5)
   05167 Kaposi sarcoma-associated herpesvirus infection
    10681 (GNB5)
  09165 Substance dependence
   05032 Morphine addiction
    10681 (GNB5)
   05034 Alcoholism
    10681 (GNB5)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    10681 (GNB5)
   04031 GTP-binding proteins [BR:hsa04031]
    10681 (GNB5)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   10681 (GNB5)
GTP-binding proteins [BR:hsa04031]
 Heterotrimeric G-proteins
  Beta Subunits
   Beta [OT]
    10681 (GNB5)
SSDB
Motif
Pfam: WD40 ANAPC4_WD40 NBCH_WD40 WD40_like DUF2538
Other DBs
NCBI-GeneID: 10681
NCBI-ProteinID: NP_057278
OMIM: 604447
HGNC: 4401
Ensembl: ENSG00000069966
UniProt: O14775
Structure
Position
15:complement(52115100..52191392)
AA seq 395 aa
MCDQTFLVNVFGSCDKCFKQRALRPVFKKSQQLSYCSTCAEIMATEGLHENETLASLKSE
AESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRI
VSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDK
NENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADV
LCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGS
DDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRV
SILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA
NT seq 1188 nt   +upstreamnt  +downstreamnt
atgtgtgatcagacctttctcgttaatgtatttggctcatgtgacaaatgtttcaaacaa
cgagctctgagaccagttttcaagaagtctcaacaactcagctactgttcaacatgtgca
gaaattatggcaaccgaggggctgcacgagaacgagacgctggcgtcgctgaagagcgag
gccgagagcctcaagggcaagctggaggaggagcgagccaagctgcacgatgtggagctg
caccaggtggcggagcgggtggaggccctggggcagtttgtcatgaagaccagaaggacc
ctcaaaggccacgggaacaaagtcctgtgcatggactggtgcaaagataagaggaggatc
gtgagctcgtcacaggatgggaaggtgatcgtgtgggattccttcaccacaaacaaggag
cacgcggtcaccatgccctgcacgtgggtgatggcatgtgcttatgccccatcgggatgt
gccattgcttgtggtggtttggataataagtgttctgtgtaccccttgacgtttgacaaa
aatgaaaacatggctgccaaaaagaagtctgttgctatgcacaccaactacctgtcggcc
tgcagcttcaccaactctgacatgcagatcctgacagcgagcggcgatggcacatgtgcc
ctgtgggacgtggagagcgggcagctgctgcagagcttccacggacatggggctgacgtc
ctctgcttggacctggccccctcagaaactggaaacaccttcgtgtctgggggatgtgac
aagaaagccatggtgtgggacatgcgctccggccagtgcgtgcaggcctttgaaacacat
gaatctgacatcaacagtgtccggtactaccccagtggagatgcctttgcttcagggtca
gatgacgctacgtgtcgcctctatgacctgcgggcagatagggaggttgccatctattcc
aaagaaagcatcatatttggagcatccagcgtggacttctccctcagtggtcgcctgctg
tttgctggatacaatgattacactatcaacgtctgggatgttctcaaagggtcccgggtc
tccatcctgtttggacatgaaaaccgcgttagcactctacgagtttcccccgatgggact
gctttctgctctggatcatgggatcataccctcagagtctgggcctaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (18)   
   KEGG PATHWAY (18)   
Network (25)   
   KEGG NETWORK (25)   
Disease (4)   
   KEGG DISEASE (1)   
   OMIM (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (27)   
   RefSeq(nuc) (5)   
   GenBank (11)   
   EMBL (11)   
3D Structure (18)   
   PDB (18)   
Protein domain (5)   
   Pfam (5)   
All databases (118)   

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