KEGG   Homo sapiens (human): 10765
Entry
10765             CDS       T01001                                 
Symbol
KDM5B, CT31, JARID1B, MRT65, PLU-1, PLU1, PPP1R98, PUT1, RBBP2H1A, RBP2-H1
Name
(RefSeq) lysine demethylase 5B
  KO
K11446  [histone H3]-trimethyl-L-lysine4 demethylase [EC:1.14.11.67]
Organism
hsa  Homo sapiens (human)
Disease
H00768  Autosomal recessive intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    10765 (KDM5B)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    10765 (KDM5B)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.67  [histone H3]-trimethyl-L-lysine4 demethylase
     10765 (KDM5B)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     10765 (KDM5B)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   Histone demethylases
    10765 (KDM5B)
SSDB
Motif
Pfam: PLU-1 JmjC KDM5_C-hel PHD ARID zf-C5HC2 JmjN PHD_2 zf-PHD-like Lipoprotein_20
Other DBs
NCBI-GeneID: 10765
NCBI-ProteinID: NP_006609
OMIM: 605393
HGNC: 18039
Ensembl: ENSG00000117139
UniProt: Q9UGL1
Structure
Position
1:complement(202724495..202808421)
AA seq 1544 aa
MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTG
ICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNFLDQIAKYWELQGSTLKI
PHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILN
PYNLFLSGDSLRCLQKPNLTTDTKDKEYKPHDIPQRQSVQPSETCPPARRAKRMRAEAMN
IKIEPEETTEARTHNLRRRMGCPTPKCENEKEMKSSIKQEPIERKDYIVENEKEKPKSRS
KKATNAVDLYVCLLCGSGNDEDRLLLCDGCDDSYHTFCLIPPLHDVPKGDWRCPKCLAQE
CSKPQEAFGFEQAARDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEED
VTVEYGADIASKEFGSGFPVRDGKIKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADIC
GMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPE
LFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAV
NFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIE
DEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSAISCSCKPGLLVCLHHVK
ELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAESYNEWALNVNEALEAKINKKKSLVSFK
ALIEESEMKKFPDNDLLRHLRLVTQDAEKCASVAQQLLNGKRQTRYRSGGGKSQNQLTVN
ELRQFVTQLYALPCVLSQTPLLKDLLNRVEDFQQHSQKLLSEETPSAAELQDLLDVSFEF
DVELPQLAEMRIRLEQARWLEEVQQACLDPSSLTLDDMRRLIDLGVGLAPYSAVEKAMAR
LQELLTVSEHWDDKAKSLLKARPRHSLNSLATAVKEIEEIPAYLPNGAALKDSVQRARDW
LQDVEGLQAGGRVPVLDTLIELVTRGRSIPVHLNSLPRLETLVAEVQAWKECAVNTFLTE
NSPYSLLEVLCPRCDIGLLGLKRKQRKLKEPLPNGKKKSTKLESLSDLERALTESKETAS
AMATLGEARLREMEALQSLRLANEGKLLSPLQDVDIKICLCQKAPAAPMIQCELCRDAFH
TSCVAVPSISQGLRIWLCPHCRRSEKPPLEKILPLLASLQRIRVRLPEGDALRYMIERTV
NWQHRAQQLLSSGNLKFVQDRVGSGLLYSRWQASAGQVSDTNKVSQPPGTTSFSLPDDWD
NRTSYLHSPFSTGRSCIPLHGVSPEVNELLMEAQLLQVSLPEIQELYQTLLAKPSPAQQT
DRSSPVRPSSEKNDCCRGKRDGINSLERKLKRRLEREGLSSERWERVKKMRTPKKKKIKL
SHPKDMNNFKLERERSYELVRSAETHSLPSDTSYSEQEDSEDEDAICPAVSCLQPEGDEV
DWVQCDGSCNQWFHQVCVGVSPEMAEKEDYICVRCTVKDAPSRK
NT seq 4635 nt   +upstreamnt  +downstreamnt
atggaggcggccaccacactgcacccaggcccgcgcccggcgctgcccctcgggggcccg
ggcccgctgggcgagttcctgcctccacccgagtgcccggtcttcgaacccagctgggaa
gagttcgcggaccccttcgctttcatccacaagatccggcccatagccgagcagactggc
atctgtaaggtgcggccgccgccggattggcagccaccatttgcatgtgatgttgataaa
cttcattttacgccacgtatccagagactgaatgaattggaggcccaaactcgtgtaaaa
ttgaatttcttggaccagattgcaaagtactgggagttacagggaagtactctgaaaatt
ccacatgtggagaggaagatcttggacttatttcagcttaataagttagttgcagaagaa
ggtggatttgcagttgtttgcaaggatagaaaatggaccaaaattgctaccaagatgggg
tttgctcctggcaaagcagtgggctcacatatcagagggcattatgaacgaattctcaac
ccctacaacttattcctgtccggagacagcctaaggtgtttgcagaagccaaacctgacc
acagacactaaggacaaggagtacaaaccccatgatattccccagaggcagtctgtgcag
ccttcggaaacgtgccccccagcccgacgagcaaaacgcatgagagcagaggccatgaat
attaaaatagaacccgaggagacaacggaagccagaactcataatctgagacgtcgaatg
ggttgtccaactccaaaatgtgaaaatgagaaagaaatgaagagtagcatcaagcaagaa
cctattgagaggaaagattatattgtagaaaatgagaaggaaaagcccaagagtcgatct
aaaaaagccaccaatgctgtggacctgtatgtctgtcttttatgtggcagtggcaatgat
gaagaccggctactgttgtgtgatggctgtgatgacagttaccataccttttgcttgatc
ccacctctccatgatgttcccaagggagactggaggtgtcctaagtgtttggctcaggaa
tgtagtaagccacaagaagcatttggctttgaacaagcagccagggactataccctccgt
acttttggggaaatggcagatgcgttcaaatctgattacttcaacatgccagtccatatg
gtccccacagagcttgttgagaaagaattttggagactagtaagcactattgaggaggat
gtcacagtggaatatggagctgacattgcctcaaaggaatttggcagtggctttcctgtc
cgagatgggaaaatcaaactctcacctgaggaagaggagtatcttgatagtggctggaat
ttgaacaacatgccagtgatggagcagtctgtccttgcacatattactgctgatatatgt
ggcatgaaacttccttggttgtatgtgggaatgtgcttttcttcattctgttggcacatt
gaagaccactggagctattcaattaactacttgcactggggtgagccaaaaacctggtat
ggagtcccagggtatgctgctgagcagctagaaaatgtaatgaagaaactagctccagaa
ctctttgtgtcccagccggatctcctccatcagcttgtgaccatcatgaaccccaatacc
ctgatgactcatgaagtgcctgtttaccgaactaatcagtgtgctggggagtttgtgatt
acatttccaagagcctaccacagtggttttaaccagggttttaattttgctgaggctgtt
aacttctgcactgttgattggctgccattaggccgacagtgtgtggagcattatcgcttg
cttcatcgatattgtgtgttttcccacgatgagatgatctgcaagatggcttccaaggct
gatgtattagatgttgtagtggcttcaactgttcagaaagacatggccattatgattgag
gatgagaaagctttaagagaaactgtccgtaaattgggagtgattgattcggaaagaatg
gattttgagctgttgccagatgatgaacgtcagtgtgtaaaatgcaaaactacatgcttc
atgtctgccatctcctgttcttgtaaacctggccttcttgtttgcctgcatcatgtaaaa
gaattgtgttcctgtcctccttacaaatataaattgcggtataggtacacgctggatgat
ctctaccctatgatgaatgcattgaagcttcgagcagaatcttacaacgaatgggccttg
aatgtgaatgaagctttggaggcaaagatcaacaagaagaaaagccttgtcagcttcaag
gctttaattgaagaatctgaaatgaagaaattcccagacaatgatcttttgcgacacctt
cgcctagtcacacaggatgcagagaagtgtgcctctgttgcgcagcagttgcttaatggc
aaaaggcaaactagatatcgatctggtggagggaaatcccaaaatcagttgacagtgaat
gagctccggcagtttgtaacacagctgtatgctcttccatgtgtcctcagtcagacacca
ttactaaaggatctcttgaatcgtgtagaagattttcaacagcatagtcagaaactactc
tctgaggaaacgcctagtgctgcggagctgcaggacttgctagatgtcagctttgaattt
gatgttgaacttccacagcttgctgagatgcgtatccgtttggaacaagcccgttggcta
gaagaggtgcagcaagcttgcctagaccccagctcccttactttagatgatatgagacgt
ctcatagacctaggggtagggctggccccgtattcagcagtggagaaagctatggcccgg
ctgcaggaactgctcacagtgtcagagcactgggacgacaaagccaagagtctcctcaag
gccaggccacgacattcattgaatagccttgctacggcagtaaaggaaatcgaagagatc
cctgcatatctgcccaatggtgcggctctgaaagactcagtgcagagagccagagactgg
cttcaggatgtagagggcctgcaggctggaggacgtgtgccagtgttagacacactcata
gaacttgttacacgaggccgatctatccccgtacatctgaattctttgccaagactggaa
accctagtagctgaggttcaggcttggaaagaatgtgctgttaatacattcttgactgag
aattctccatattctctcttagaggtgctgtgtcctcgatgtgatattggccttttggga
ttgaaaaggaagcagagaaagttaaaggagcccttgccaaatggaaagaaaaaaagcacc
aaattagagagtctgagtgacctggagagagctttaactgaaagcaaggagactgcttca
gctatggcaactcttggggaagctcgcctaagggaaatggaagccttgcagtctctcaga
ctcgccaatgaagggaaattgctgtcgcctctccaagatgtggatataaaaatctgccta
tgtcagaaggccccagctgcccctatgattcaatgtgaactctgcagggatgctttccac
accagttgtgtggcggtacccagtatttcacagggcctgcgaatctggctttgtccccat
tgtcggaggtcagagaaacctccattagagaaaattctgcccctgctcgcctcccttcag
cgtatccgagttcgccttcctgagggagatgcacttcgatatatgattgaaagaaccgtg
aactggcagcacagagcccagcaactgctttcgtcagggaatcttaaatttgtgcaagat
cgagtgggctcaggactgttatatagcagatggcaagcctcagcaggacaggtgtcagac
acaaacaaggtatctcaacctcctggcacaacatcattttctttgcctgatgactgggac
aacagaacctcatatttgcactcccccttctcaactggacgaagttgtatccccctccat
ggtgttagtccagaagtgaatgaactattgatggaagcccagctgctccaggtatccctt
cctgaaattcaggaactttaccagactttacttgcaaagccaagccctgctcagcagact
gaccgaagctcaccagtgagacccagcagtgagaagaatgactgttgccgagggaagcga
gatggaattaacagtcttgagagaaaactgaagagacgcctggaaagagagggcctctcc
agtgagcggtgggaacgagttaagaaaatgcggacccccaaaaagaagaaaatcaaactg
agccaccccaaggacatgaacaatttcaagttagagagagagcgtagctatgaattagtt
cgttctgctgaaactcattccctgccctcagacacatcctattccgaacaggaagactct
gaggatgaagatgccatctgcccagctgtgagctgcctgcagccagaaggagatgaggtg
gactgggtccagtgtgatggcagctgcaatcagtggtttcatcaggtctgtgttggtgtc
tccccagagatggcagagaaagaagactacatctgtgtgcgctgtactgtgaaggacgca
ccaagccgaaagtaa

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (26)   
   KEGG ORTHOLOGY (1)   
   RefGene (20)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (10)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (44)   
   RefSeq(nuc) (8)   
   GenBank (18)   
   EMBL (18)   
3D Structure (56)   
   PDB (56)   
Protein domain (10)   
   Pfam (10)   
All databases (155)   

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