KEGG   Homo sapiens (human): 10914
Entry
10914             CDS       T01001                                 
Symbol
PAPOLA, PAP, PAP-alpha
Name
(RefSeq) poly(A) polymerase alpha
  KO
K14376  poly(A) polymerase [EC:2.7.7.19]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03015  mRNA surveillance pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   03015 mRNA surveillance pathway
    10914 (PAPOLA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    10914 (PAPOLA)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.19  polynucleotide adenylyltransferase
     10914 (PAPOLA)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA processing factors
   3' end processing
    Poly(A) addition factors
     10914 (PAPOLA)
SSDB
Motif
Pfam: PAP_NTPase PAP_central PAP_RNA-bind NTP_transf_2 Polbeta
Other DBs
NCBI-GeneID: 10914
NCBI-ProteinID: NP_116021
OMIM: 605553
HGNC: 14981
Ensembl: ENSG00000090060
UniProt: P51003
Position
14:96502376..96567116
AA seq 745 aa
MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
ATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT
QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES
PKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAASLLASQKTSSTD
LSDIPALPANPIPVIKNSIKLRLNR
NT seq 2238 nt   +upstreamnt  +downstreamnt
atgccgtttccagttacaacacagggatcacaacaaacacaaccgccacagaagcactat
ggcattacttctcctatcagcttagcagcccccaaggagactgactgcgtacttacacag
aaactaattgagacattgaaaccctttggggtttttgaagaggaagaggaactgcagcgc
aggattttaattttgggaaaactaaataacctggtaaaagagtggatacgagaaatcagt
gaaagcaagaatcttccacaatctgtaattgaaaatgttggaggaaaaatttttacattt
ggatcttacagattaggagtgcatacaaaaggtgctgatattgatgcgttgtgtgttgca
ccaagacatgttgatcgaagtgactttttcacctcattctatgataagttgaaattacag
gaagaagtaaaagatttaagagctgttgaagaggcattcgtaccagttattaaactctgt
tttgatgggatagagattgatattttgtttgcaagattagcactgcagacaattcctgaa
gatttggatctacgagatgacagtctgctaaaaaatttagatataagatgtataagaagt
cttaacggttgcagggtaaccgatgaaattttacatctagtaccaaacattgacaacttc
aggttaactctgagagctatcaaactatgggccaaacgccacaacatctattccaatata
ttaggtttcctcggtggtgtttcctgggctatgctagtagcaagaacttgccagctttat
ccaaatgcaatagcatcaactcttgtacataaatttttcttggtattttctaaatgggaa
tggccaaatccagtgctattgaaacagcctgaagaatgcaatcttaatttgcctgtatgg
gacccaagggtaaaccccagtgataggtaccatcttatgcctataattacaccagcatac
ccacaacagaactccacgtacaatgtgtccgtttcaacacggatggtcatggttgaggag
tttaaacaaggtcttgctatcacagatgaaattttgctgagtaaggcagagtggtccaaa
ctttttgaagctccaaacttctttcaaaagtacaagcattatattgtacttctagcaagt
gcaccaacagaaaaacaacgcctggaatgggtgggcttggtggaatcaaaaatccgaatc
ctggttggaagcttggagaagaatgaatttattacactggctcatgtgaatccccagtca
tttccagcacccaaagaaaatcccgacaaggaagaatttcgcacgatgtgggtgattggg
ttagtgtttaaaaaaacagaaaactctgaaaacctcagtgttgatctcacctatgatatt
cagtctttcacagatacagtttataggcaagcaataaacagcaagatgtttgaggtggat
atgaaaattgctgcaatgcatgtaaaaagaaagcaactccatcaactactacctaatcat
gtgcttcagaaaaagaaaaagcattcaacagaaggtgtcaaattgacagctctcaatgac
agcagcctcgacttgtctatggacagtgataacagcatgtctgtgccttcacctactagt
gctacgaagaccagtccattgaacagttctggcagctctcagggcagaaacagtcctgct
ccagctgtaacagcagcatctgtgaccaacatacaggctactgaagtttctgtgccacaa
gtaaattccagtgaaagctcagggggtacatcgagtgaaagcattcctcaaactgccaca
caaccagccatttctccaccaccaaagcctacggtctccagagttgtttcttcaacacgt
ctggtaaacccaccacctagatcttcaggaaatgcagcaacttcaggaaatgcagcaaca
aaaatacctactcctatagtaggagtcaagaggacatcctcacctcataaagaagagagt
cccaagaaaaccaaaacagaagaggatgaaacaagtgaagatgctaactgtcttgctttg
agtggacatgataaaacagaagcaaaggaacaacttgatacagagacaagtacaactcaa
tcagaaactattcagacagcggcttctctgttggcctctcagaaaacatccagtacagac
ctttctgatatccctgctctccctgcaaatcctattcctgttatcaagaattcaataaaa
ctgagattgaatcggtaa

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (12)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (10)   
DNA sequence (56)   
   RefSeq(nuc) (10)   
   GenBank (23)   
   EMBL (23)   
Protein domain (5)   
   Pfam (5)   
All databases (100)   

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