KEGG   Homo sapiens (human): 11113
Entry
11113             CDS       T01001                                 
Symbol
CIT, CITK, CRIK, MCPH17, STK21
Name
(RefSeq) citron rho-interacting serine/threonine kinase
  KO
K16308  citron Rho-interacting kinase [EC:2.7.11.35]
Organism
hsa  Homo sapiens (human)
Disease
H00269  Primary microcephaly
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    11113 (CIT)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.35  CRIK-subfamily protein kinase
     11113 (CIT)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  DMPK family [OT]
   11113 (CIT)
SSDB
Motif
Pfam: CNH Pkinase PK_Tyr_Ser-Thr PH C1_1 Pkinase_C Seadorna_VP7 APH
Other DBs
NCBI-GeneID: 11113
NCBI-ProteinID: NP_009105
OMIM: 605629
HGNC: 1985
Ensembl: ENSG00000122966
UniProt: O14578
Position
12:complement(119685791..119877320)
AA seq 2027 aa
MLKFKYGARNPLDAGAAEPIASRASRLNLFFQGKPPFMTQQQMSPLSREGILDALFVLFE
ECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGCGHFAEVQVVREKATG
DIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGG
DLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDF
GSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGR
SPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLLCGQKERLKFEGLCCHPFF
SKIDWNNIRNSPPPFVPTLKSDDDTSNFDEPEKNSWVSSSPCQLSPSGFSGEELPFVGFS
YSKALGILGRSESVVSGLDSPAKTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVS
EVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLH
DIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFK
RKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQ
NIRQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQH
YEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQR
IVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKI
SHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAAL
ESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDN
AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCT
MLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQ
RITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQ
KLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLEN
IQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNE
LKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQIAMSAIV
RSPEHQPSAMSLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCAVCL
DTVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFCRDKMNSPGLQTKEP
SSSLHLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELCLPDG
DVSIHGAVGASELANTAKADVPYILKMESHPHTTCWPGRTLYLLAPSFPDKQRWVTALES
VVAGGRVSREKAEADAKLLGNSLLKLEGDDRLDMNCTLPFSDQVVLVGTEEGLYALNVLK
NSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLPAQPDISPN
IFEAVKGCHLFGAGKIENGLCICAAMPSKVVILRYNENLSKYCIRKEIETSEPCSCIHFT
NYSILIGTNKFYEIDMKQYTLEEFLDKNDHSLAPAVFAASSNSFPVSIVQVNSAGQREEY
LLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSAGT
PARAYLDIPNPRYLGPAISSGAIYLASSYQDKLRVICCKGNLVKESGTEHHRGPSTSRSS
PNKRGPPTYNEHITKRVASSPAPPEGPSHPREPSTPHRYREGRTELRRDKSPGRPLEREK
SPGRMLSTRRERSPGRLFEDSSRGRLPAGAVRTPLSQVNKVWDQSSV
NT seq 6084 nt   +upstreamnt  +downstreamnt
atgttgaagttcaaatatggagcgcggaatcctttggatgctggtgctgctgaacccatt
gccagccgggcctccaggctgaatctgttcttccaggggaaaccaccctttatgactcaa
cagcagatgtctcctctttcccgagaagggatattagatgccctctttgttctctttgaa
gaatgcagtcagcctgctctgatgaagattaagcacgtgagcaactttgtccggaagtat
tccgacaccatagctgagttacaggagctccagccttcggcaaaggacttcgaagtcaga
agtcttgtaggttgtggtcactttgctgaagtgcaggtggtaagagagaaagcaaccggg
gacatctatgctatgaaagtgatgaagaagaaggctttattggcccaggagcaggtttca
ttttttgaggaagagcggaacatattatctcgaagcacaagcccgtggatcccccaatta
cagtatgcctttcaggacaaaaatcacctttatctggtcatggaatatcagcctggaggg
gacttgctgtcacttttgaatagatatgaggaccagttagatgaaaacctgatacagttt
tacctagctgagctgattttggctgttcacagcgttcatctgatgggatacgtgcatcga
gacatcaagcctgagaacattctcgttgaccgcacaggacacatcaagctggtggatttt
ggatctgccgcgaaaatgaattcaaacaagatggtgaatgccaaactcccgattgggacc
ccagattacatggctcctgaagtgctgactgtgatgaacggggatggaaaaggcacctac
ggcctggactgtgactggtggtcagtgggcgtgattgcctatgagatgatttatgggaga
tcccccttcgcagagggaacctctgccagaaccttcaataacattatgaatttccagcgg
tttttgaaatttccagatgaccccaaagtgagcagtgactttcttgatctgattcaaagc
ttgttgtgcggccagaaagagagactgaagtttgaaggtctttgctgccatcctttcttc
tctaaaattgactggaacaacattcgtaactctcctccccccttcgttcccaccctcaag
tctgacgatgacacctccaattttgatgaaccagagaagaattcgtgggtttcatcctct
ccgtgccagctgagcccctcaggcttctcgggtgaagaactgccgtttgtggggttttcg
tacagcaaggcactggggattcttggtagatctgagtctgttgtgtcgggtctggactcc
cctgccaagactagctccatggaaaagaaacttctcatcaaaagcaaagagctacaagac
tctcaggacaagtgtcacaagatggagcaggaaatgacccggttacatcggagagtgtca
gaggtggaggctgtgcttagtcagaaggaggtggagctgaaggcctctgagactcagaga
tccctcctggagcaggaccttgctacctacatcacagaatgcagtagcttaaagcgaagt
ttggagcaagcacggatggaggtgtcccaggaggatgacaaagcactgcagcttctccat
gatatcagagagcagagccggaagctccaagaaatcaaagagcaggagtaccaggctcaa
gtggaagaaatgaggttgatgatgaatcagttggaagaggatcttgtctcagcaagaaga
cggagtgatctctacgaatctgagctgagagagtctcggcttgctgctgaagaattcaag
cggaaagcgacagaatgtcagcataaactgttgaaggctaaggatcaagggaagcctgaa
gtgggagaatatgcgaaactggagaagatcaatgctgagcagcagctcaaaattcaggag
ctccaagagaaactggagaaggctgtaaaagccagcacggaggccaccgagctgctgcag
aatatccgccaggcaaaggagcgagccgagagggagctggagaagctgcagaaccgagag
gattcttctgaaggcatcagaaagaagctggtggaagctgaggagctcgaagagaaacat
cgggaggcccaagtctcagcccagcacctagaagtgcacctgaaacagaaagagcagcac
tatgaggaaaagattaaagtgttggacaatcagataaagaaagacctggctgacaaggag
acactggagaacatgatgcagagacacgaggaggaggcccatgagaagggcaaaattctc
agcgaacagaaggcgatgatcaatgctatggattccaagatcagatccctggaacagagg
attgtggaactgtctgaagccaataaacttgcagcaaatagcagtctttttacccaaagg
aacatgaaggcccaagaagagatgatttctgaactcaggcaacagaaattttacctggag
acacaggctgggaagttggaggcccagaaccgaaaactggaggagcagctggagaagatc
agccaccaagaccacagtgacaagaatcggctgctggaactggagacaagattgcgggag
gtcagtctagagcacgaggagcagaaactggagctcaagcgccagctcacagagctacag
ctctccctgcaggagcgcgagtcacagttgacagccctgcaggctgcacgggcggccctg
gagagccagcttcgccaggcgaagacagagctggaagagaccacagcagaagctgaagag
gagatccaggcactcacggcacatagagatgaaatccagcgcaaatttgatgctcttcgt
aacagctgtactgtaatcacagacctggaggagcagctaaaccagctgaccgaggacaac
gctgaactcaacaaccaaaacttctacttgtccaaacaactcgatgaggcttctggcgcc
aacgacgagattgtacaactgcgaagtgaagtggaccatctccgccgggagatcacggaa
cgagagatgcagcttaccagccagaagcaaacgatggaggctctgaagaccacgtgcacc
atgctggaggaacaggtcatggatttggaggccctaaacgatgagctgctagaaaaagag
cggcagtgggaggcctggaggagcgtcctgggtgatgagaaatcccagtttgagtgtcgg
gttcgagagctgcagagaatgctggacaccgagaaacagagcagggcgagagccgatcag
cggatcaccgagtctcgccaggtggtggagctggcagtgaaggagcacaaggctgagatt
ctcgctctgcagcaggctctcaaagagcagaagctgaaggccgagagcctctctgacaag
ctcaatgacctggagaagaagcatgctatgcttgaaatgaatgcccgaagcttacagcag
aagctggagactgaacgagagctcaaacagaggcttctggaagagcaagccaaattacag
cagcagatggacctgcagaaaaatcacattttccgtctgactcaaggactgcaagaagct
ctagatcgggctgatctactgaagacagaaagaagtgacttggagtatcagctggaaaac
attcaggttctctattctcatgaaaaggtgaaaatggaaggcactatttctcaacaaacc
aaactcattgattttctgcaagccaaaatggaccaacctgctaaaaagaaaaagggttta
tttagtcgacggaaagaggaccctgctttacccacacaggttcctctgcagtacaatgag
ctgaagctggccctggagaaggagaaagctcgctgtgcagagctagaggaagcccttcag
aagacccgcatcgagctccggtccgcccgggaggaagctgcccaccgcaaagcaacggac
cacccacacccatccacgccagccaccgcgaggcagcagatcgccatgtccgccatcgtg
cggtcgccagagcaccagcccagtgccatgagcctgctggccccgccatccagccgcaga
aaggagtcttcaactccagaggaatttagtcggcgtcttaaggaacgcatgcaccacaat
attcctcaccgattcaacgtaggactgaacatgcgagccacaaagtgtgctgtgtgtctg
gataccgtgcactttggacgccaggcatccaaatgtctcgaatgtcaggtgatgtgtcac
cccaagtgctccacgtgcttgccagccacctgcggcttgcctgctgaatatgccacacac
ttcaccgaggccttctgccgtgacaaaatgaactccccaggtctccagaccaaggagccc
agcagcagcttgcacctggaagggtggatgaaggtgcccaggaataacaaacgaggacag
caaggctgggacaggaagtacattgtcctggagggatcaaaagtcctcatttatgacaat
gaagccagagaagctggacagaggccggtggaagaatttgagctgtgccttcccgacggg
gatgtatctattcatggtgccgttggtgcttccgaactcgcaaatacagccaaagcagat
gtcccatacatactgaagatggaatctcacccgcacaccacctgctggcccgggagaacc
ctctacttgctagctcccagcttccctgacaaacagcgctgggtcaccgccttagaatca
gttgtcgcaggtgggagagtttctagggaaaaagcagaagctgatgctaaactgcttgga
aactccctgctgaaactggaaggtgatgaccgtctagacatgaactgcacgctgcccttc
agtgaccaggtggtgttggtgggcaccgaggaagggctctacgccctgaatgtcttgaaa
aactccctaacccatgtcccaggaattggagcagtcttccaaatttatattatcaaggac
ctggagaagctactcatgatagcaggagaagagcgggcactgtgtcttgtggacgtgaag
aaagtgaaacagtccctggcccagtcccacctgcctgcccagcccgacatctcacccaac
atttttgaagctgtcaagggctgccacttgtttggggcaggcaagattgagaacgggctc
tgcatctgtgcagccatgcccagcaaagtcgtcattctccgctacaacgaaaacctcagc
aaatactgcatccggaaagagatagagacctcagagccctgcagctgtatccacttcacc
aattacagtatcctcattggaaccaataaattctacgaaatcgacatgaagcagtacacg
ctcgaggaattcctggataagaatgaccattccttggcacctgctgtgtttgccgcctct
tccaacagcttccctgtctcaatcgtgcaggtgaacagcgcagggcagcgagaggagtac
ttgctgtgtttccacgaatttggagtgttcgtggattcttacggaagacgtagccgcaca
gacgatctcaagtggagtcgcttacctttggcctttgcctacagagaaccctatctgttt
gtgacccacttcaactcactcgaagtaattgagatccaggcacgctcctcagcagggacc
cctgcccgagcgtacctggacatcccgaacccgcgctacctgggccctgccatttcctca
ggagcgatttacttggcgtcctcataccaggataaattaagggtcatttgctgcaaggga
aacctcgtgaaggagtccggcactgaacaccaccggggcccgtccacctcccgcagcagc
cccaacaagcgaggcccacccacgtacaacgagcacatcaccaagcgcgtggcctccagc
ccagcgccgcccgaaggccccagccacccgcgagagccaagcacaccccaccgctaccgc
gaggggcggaccgagctgcgcagggacaagtctcctggccgccccctggagcgagagaag
tcccccggccggatgctcagcacgcggagagagcggtcccccgggaggctgtttgaagac
agcagcaggggccggctgcctgcgggagccgtgaggaccccgctgtcccaggtgaacaag
gtctgggaccagtcttcagtataa

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Ontology (3)   
   KEGG BRITE (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (34)   
   KEGG ORTHOLOGY (1)   
   RefGene (26)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (30)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (28)   
DNA sequence (42)   
   RefSeq(nuc) (28)   
   GenBank (7)   
   EMBL (7)   
Protein domain (8)   
   Pfam (8)   
All databases (122)   

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