KEGG   Homo sapiens (human): 11221
Entry
11221             CDS       T01001                                 
Symbol
DUSP10, MKP-5, MKP5
Name
(RefSeq) dual specificity phosphatase 10
  KO
K20216  dual specificity phosphatase 10 [EC:3.1.3.16 3.1.3.48]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
Network
nt06526  MAPK signaling
  Element
N01593  Regulation of GF-RTK-RAS-ERK signaling, PTP
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    11221 (DUSP10)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    11221 (DUSP10)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     11221 (DUSP10)
    3.1.3.48  protein-tyrosine-phosphatase
     11221 (DUSP10)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   MAPK phosphatases
    11221 (DUSP10)
SSDB
Motif
Pfam: DSPc Rhodanese PTPlike_phytase Init_tRNA_PT Y_phosphatase
Other DBs
NCBI-GeneID: 11221
NCBI-ProteinID: NP_009138
OMIM: 608867
HGNC: 3065
Ensembl: ENSG00000143507
UniProt: Q9Y6W6
Structure
Position
1:complement(221701424..221742089)
AA seq 482 aa
MPPSPLDDRVVVALSRPVRPQDLNLCLDSSYLGSANPGSNSHPPVIATTVVSLKAANLTY
MPSSSGSARSLNCGCSSASCCTVATYDKDNQAQTQAIAAGTTTTAIGTSTTCPANQMVNN
NENTGSLSPSSGVGSPVSGTPKQLASIKIIYPNDLAKKMTKCSKSHLPSQGPVIIDCRPF
MEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENT
NEPSRVMPSQPLHIVLESLKREGKEPLVLKGGLSSFKQNHENLCDNSLQLQECREVGGGA
SAASSLLPQPIPTTPDIENAELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPL
YHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVI
AYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLNNGVTPRILTPKLMGVET
VV
NT seq 1449 nt   +upstreamnt  +downstreamnt
atgcctccgtctcctttagacgacagggtagtagtggcactatctaggcccgtccgacct
caggatctcaacctttgtttagactctagttaccttggctctgccaacccaggcagtaac
agccaccctcctgtcatcgccaccaccgttgtgtccctcaaggctgcgaatctgacgtat
atgccctcatccagcggctctgcccgctcgctgaattgtggatgcagcagtgccagctgc
tgcactgtggcaacctacgacaaggacaatcaggcccaaacccaagccattgccgctggc
accaccaccactgccatcggaacctctaccacctgccctgctaaccagatggtcaacaat
aatgagaatacaggctctctaagtccatcaagtggggtgggcagccctgtgtcagggacc
cccaagcagctagccagcatcaaaataatctaccccaatgacttggcaaagaagatgacc
aaatgcagcaagagtcacctgccgagtcagggccctgtcatcattgactgcaggcccttc
atggagtacaacaagagtcacatccaaggagctgtccacattaactgtgccgataagatc
agccggcggagactgcagcagggcaagatcactgtcctagacttgatttcctgtagggaa
ggcaaggactctttcaagaggatcttttccaaagaaattatagtttatgatgagaatacc
aatgaaccaagccgagtgatgccctcccagccacttcacatagtcctcgagtccctgaag
agagaaggcaaagaacctctggtgttgaaaggtggacttagtagttttaagcagaaccat
gaaaacctctgtgacaactccctccagctccaagagtgccgggaggtggggggcggcgca
tccgcggcctcgagcttgctacctcagcccatccccaccacccctgacatcgagaacgct
gagctcacccccatcttgcccttcctgttccttggcaatgagcaggatgctcaggacctg
gacaccatgcagcggctgaacatcggctacgtcatcaacgtcaccactcatcttcccctc
taccactatgagaaaggcctgttcaactacaagcggctgccagccactgacagcaacaag
cagaacctgcggcagtactttgaagaggcttttgagttcattgaggaagctcaccagtgt
gggaaggggcttctcatccactgccaggctggggtgtcccgctccgccaccatcgtcatc
gcttacttgatgaagcacactcggatgaccatgactgatgcttataaatttgtcaaaggc
aaacgaccaattatctccccaaaccttaacttcatggggcagttgctagagttcgaggaa
gacctaaacaacggtgtgacaccgagaatccttacaccaaagctgatgggcgtggagacg
gttgtgtga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Chemical reaction (2)   
   KEGG ENZYME (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (43)   
   RefSeq(nuc) (11)   
   GenBank (16)   
   EMBL (16)   
3D Structure (15)   
   PDB (15)   
Protein domain (5)   
   Pfam (5)   
All databases (101)   

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