KEGG   Homo sapiens (human): 11277
Entry
11277             CDS       T01001                                 
Symbol
TREX1, AGS1, CRV, DRN3, HERNS, RVCLS
Name
(RefSeq) three prime repair exonuclease 1
  KO
K10790  three prime repair exonuclease 1 [EC:3.1.11.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04623  Cytosolic DNA-sensing pathway
Network
nt06520  CGAS-STING signaling
  Element
N01571  DNA degradation by extracellular/endolysosomal DNAse
Disease
H00080  Systemic lupus erythematosus
H00290  Aicardi-Goutieres syndrome
H00291  Familial chilblain lupus (FCL)
H01000  Retinal vasculopathy with cerebral leukodystrophy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04623 Cytosolic DNA-sensing pathway
    11277 (TREX1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    11277 (TREX1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.11  Exodeoxyribonucleases producing 5'-phosphomonoesters
    3.1.11.2  exodeoxyribonuclease III
     11277 (TREX1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  Other factors with a suspected DNA repair function
   Nucleases
    11277 (TREX1)
SSDB
Motif
Pfam: RNase_T Herpesvir_UL11
Other DBs
NCBI-GeneID: 11277
NCBI-ProteinID: NP_338599
OMIM: 606609
HGNC: 12269
Ensembl: ENSG00000213689
UniProt: Q9NSU2
Structure
Position
3:48465830..48467645
AA seq 314 aa
MGSQALPPGPMQTLIFFDMEATGLPFSQPKVTELCLLAVHRCALESPPTSQGPPPTVPPP
PRVVDKLSLCVAPGKACSPAASEITGLSTAVLAAHGRQCFDDNLANLLLAFLRRQPQPWC
LVAHNGDRYDFPLLQAELAMLGLTSALDGAFCVDSITALKALERASSPSEHGPRKSYSLG
SIYTRLYGQSPPDSHTAEGDVLALLSICQWRPQALLRWVDAHARPFGTIRPMYGVTASAR
TKPRPSAVTTTAHLATTRNTSPSLGESRGTKDLPPVKDPGALSREGLLAPLGLLAILTLA
VATLYGLSLATPGE
NT seq 945 nt   +upstreamnt  +downstreamnt
atgggctcgcaggccctgcccccggggcccatgcagaccctcatctttttcgacatggag
gccactggcttgcccttctcccagcccaaggtcacggagctgtgcctgctggctgtccac
agatgtgccctggagagcccccccacctctcaggggccacctcccacagttcctccacca
ccgcgtgtggtagacaagctctccctgtgtgtggctccggggaaggcctgcagccctgca
gccagcgagatcacaggtctgagcacagctgtgctggcagcgcatgggcgtcaatgtttt
gatgacaacctggccaacctgctcctagccttcctgcggcgccagccacagccctggtgc
ctggtggcacacaatggtgaccgctacgacttccccctgctccaagcagagctggctatg
ctgggcctcaccagtgctctggatggtgccttctgtgtggatagcatcactgcgctgaag
gccctggagcgagcaagcagcccctcagaacacggcccaaggaagagctatagcctaggc
agcatctacactcgcctgtatgggcagtcccctccagactcgcacacggctgagggtgat
gtcctggccctgctcagcatctgtcagtggagaccacaggccctgctgcggtgggtggat
gctcacgccaggcctttcggcaccatcaggcccatgtatggggtcacagcctctgctagg
accaagccaagaccatctgctgtcacaaccactgcacacctggccacaaccaggaacact
agtcccagccttggagagagcaggggtaccaaggatcttcctccagtgaaggaccctgga
gccctatccagggaggggctgctggccccactgggtctgctggccatcctgaccttggca
gtagccacactgtatggactatccctggccacacctggggagtag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (9)   
   KEGG DISEASE (4)   
   OMIM (5)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (7)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (31)   
   RefSeq(nuc) (5)   
   GenBank (13)   
   EMBL (13)   
3D Structure (4)   
   PDB (4)   
Protein domain (2)   
   Pfam (2)   
All databases (76)   

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