KEGG T01001: 1132

Homo sapiens (human): 1132

Entry

1132              CDS       T01001

Symbol

CHRM4, HM4, M4R

Name

(RefSeq) cholinergic receptor muscarinic 4

K04132

muscarinic acetylcholine receptor M4

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04725

Cholinergic synapse

hsa04810

Regulation of actin cytoskeleton

Drug target

Acetylcholine (DG01133):

D00999<JP/US>

Aclatonium (DG01291):

D01955

Aclidinium bromide:

D08837<JP/US>

Anisotropine methylbromide:

D00232

Atropine (DG00052):

D00113 D02069<JP/US>

Atropine oxide (DG01243):

D03011 D07477

Batefenterol (DG01627):

D10545 D10546

Benapryzine hydrochloride:

D03076

Benzatropine (DG00859):

D00778<US> D07511

Benzetimide (DG01301):

D03087 D07513

Benzilone:

D03088

Bethanechol (DG00991):

D01000<JP/US>

Bevonium:

D01532

Biperiden (DG00852):

D00779 D02246<JP> D02247<JP>

Blarcamesine (DG03048):

D11383 D11549

Bornaprine:

D07302

Butropium bromide:

D01491

Butylscopolamine:

D01451<JP>

Carbachol:

D00524<US>

Carpronium (DG01289):

D01175<JP> D09752<JP>

Chlorpromazine (DG00867):

D00270 D00789<JP/US> D03274 D04034<JP> D09819

Choline alfoscerate:

D07349

Cimetropium bromide:

D07099

Clidinium bromide:

D00716

Cyclopentolate (DG01141):

D01002<JP/US> D07759

Darotropium bromide:

D09402

Dexetimide (DG00856):

D03711 D07804

Diethazine (DG01921):

D02603 D07823

Difemerine:

D07079

Dihexyverine (DG00033):

D03824 D07821

Diphenidol (DG02880):

D01318<JP> D03858 D03859

Diphenylpiperidinomethyldioxolan iodide:

Diponium bromide:

Elantrine:

Elucaine:

Emraclidine:

Etomidoline:

Etybenzatropine:

Eucatropine hydrochloride:

Fenpiverinium:

Fentonium:

Flutropium bromide:

Glycopyrronium (DG02467):

D10939<JP/US>

Heteronium bromide:

D04434

Homatropine (DG01142):

D01004

Homatropine methylbromide:

D02070

Hyoscyamine (DG00053):

D00147 D00719 D01648 D04479

Ipratropium bromide:

D02212<JP/US>

Mazaticol (DG00857):

D03264 D08157

Mebeverine (DG00030):

D04868 D08160

Mepenzolate (DG00040):

D00720<JP>

Methacholine:

D04970<JP/US>

Methantheline (DG00036):

D00721

Methscopolamine bromide:

D00715<US>

Methylatropine (DG01242):

D01077 D03814

Methylbenactyzium bromide:

D01315

Methylscopolamine:

D01976<JP>

Metixene (DG00853):

D01871 D08209

Metoquizine:

D05012

Milameline hydrochloride:

Otilonium bromide:

Oxapium iodide:

Oxitropium bromide:

Oxybutynin (DG00478):

D00465<US> D00722<JP/US>

Parapenzolate bromide:

D05360

Pentapiperium methylsulfate:

Penthienate:

Phencarbamide:

Phenglutarimide:

Pipenzolate:

Piperidolate (DG00034):

D01165<JP> D08382

Pipethanate (DG01255):

D01521 D08384

Pipethanate ethobromide:

D01987

Pirenzepine (DG00026):

D01297 D05276<JP> D08389

Piroheptine (DG01272):

D01231<JP> D08395

Poldine:

D05535

Pridinol (DG00774):

D02064<JP> D08418 D08419

Prifinium bromide:

D01377

Procyclidine (DG00854):

D00782 D08425

Profenamine (DG00855):

D01118 D03276 D08426

Propantheline (DG00035):

D00481<JP>

Propenzolate hydrochloride:

D05628

Propiverine (DG00479):

D01007<JP> D08441

Rapacuronium bromide:

D05703

Rocuronium bromide:

D00765<JP/US>

Scopolamine (DG00065):

D00138<US> D02071

Tazomeline citrate:

D06015

Tematropium methylsulfate:

D06061

Tiemonium (DG01254):

D08595

Tiemonium iodide:

D01201

Timepidium bromide (DG00041):

D02535<JP>

Tofenacin hydrochloride:

D06175

Toquizine:

D06192

Triampyzine sulfate:

D06217

Trihexyphenidyl (DG00851):

D00787<JP/US> D08638

Tropatepine (DG00858):

D07303 D08653

Tropicamide:

D00397<JP/US>

Umeclidinium (DG01253):

D10180

Umeclidinium bromide:

D10181<JP/US>

Valethamate:

D01538

Xanomeline (DG01300):

D06330 D06331

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1132 (CHRM4)
09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    1132 (CHRM4)
09150 Organismal Systems
  09156 Nervous system
   04725 Cholinergic synapse
    1132 (CHRM4)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    1132 (CHRM4)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
  Biogenic amine
   Acetylcholine (muscarinic)
    1132 (CHRM4)

SSDB

Motif

Pfam:

7tm_1 7TM_GPCR_Srsx 7tm_4

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

11:complement(46383789..46391776)

AA seq 479 aa
MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN
RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV
MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV
PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK
TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS
ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV
PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV
LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR

NT seq 1440 nt +upstreamnt +downstreamnt
atggccaacttcacacctgtcaatggcagctcgggcaatcagtccgtgcgcctggtcacg
tcatcatcccacaatcgctatgagacggtggaaatggtcttcattgccacagtgacaggc
tccctgagcctggtgactgtcgtgggcaacatcctggtgatgctgtccatcaaggtcaac
aggcagctgcagacagtcaacaactacttcctcttcagcctggcgtgtgctgatctcatc
ataggcgccttctccatgaacctctacaccgtgtacatcatcaagggctactggcccctg
ggcgccgtggtctgcgacctgtggctggccctggactacgtggtgagcaacgcctccgtc
atgaaccttctcatcatcagctttgaccgctacttctgcgtcaccaagcctctcacctac
cctgcccggcgcaccaccaagatggcaggcctcatgattgctgctgcctgggtactgtcc
ttcgtgctctgggcgcctgccatcttgttctggcagtttgtggtgggtaagcggacggtg
cccgacaaccagtgcttcatccagttcctgtccaacccagcagtgacctttggcacagcc
attgctgccttctacctgcctgtggtcatcatgacggtgctgtacatccacatctccctg
gccagtcgcagccgagtccacaagcaccggcccgagggcccgaaggagaagaaagccaag
acgctggccttcctcaagagcccactaatgaagcagagcgtcaagaagcccccgcccggg
gaggccgcccgggaggagctgcgcaatggcaagctggaggaggcccccccgccagcgctg
ccaccgccaccgcgccccgtggctgataaggacacttccaatgagtccagctcaggcagt
gccacccagaacaccaaggaacgcccagccacagagctgtccaccacagaggccaccacg
cccgccatgcccgcccctcccctgcagccgcgggccctcaacccagcctccagatggtcc
aagatccagattgtgacgaagcagacaggcaatgagtgtgtgacagccattgagattgtg
cctgccacgccggctggcatgcgccctgcggccaacgtggcccgcaagttcgccagcatc
gctcgcaaccaggtgcgcaagaagcggcagatggcggcccgggagcgcaaagtgacacga
acgatctttgccattctgctagccttcatcctcacctggacgccctacaacgtcatggtc
ctggtgaacaccttctgccagagctgcatccctgacacggtgtggtccattggctactgg
ctctgctacgtcaacagcaccatcaaccctgcctgctatgctctgtgcaacgccaccttt
aaaaagaccttccggcacctgctgctgtgccagtatcggaacatcggcactgccaggtag

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