KEGG   Homo sapiens (human): 1134
Entry
1134              CDS       T01001                                 
Symbol
CHRNA1, ACHRA, ACHRD, CHRNA, CMS1A, CMS1B, CMS2A, FCCMS, SCCMS
Name
(RefSeq) cholinergic receptor nicotinic alpha 1 subunit
  KO
K04803  nicotinic acetylcholine receptor alpha-1
Organism
hsa  Homo sapiens (human)
Pathway
hsa03265  Virion - Ebolavirus and Lyssavirus
hsa04080  Neuroactive ligand-receptor interaction
Disease
H00770  Congenital myasthenic syndrome
H00986  Multiple pterygium syndrome
Drug target
Acetylcholine (DG01133): D00999<JP/US>
Cytisinicline: D07770
Gantacurium chloride: D04303
Lobeline (DG01287): D02202 D02364 D08138
Mecamylamine (DG00252): D00611<US>
Metocurine iodide: D00761
Nicotine (DG00994): D03365<JP/US> D05156 D05157
Suxamethonium (DG00768): D00766<US> D02275<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03265 Virion - Ebolavirus and Lyssavirus
    1134 (CHRNA1)
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1134 (CHRNA1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    1134 (CHRNA1)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Acetylcholine (nicotinic)
   1134 (CHRNA1)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb DUF4980 Claudin_2
Other DBs
NCBI-GeneID: 1134
NCBI-ProteinID: NP_000070
OMIM: 100690
HGNC: 1955
Ensembl: ENSG00000138435
UniProt: P02708 Q53SH4
Structure
Position
2:complement(174747592..174764472)
AA seq 457 aa
MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL
INVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDF
AIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINP
ESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVII
PCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLF
TMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKK
IFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWK
YVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQQG
NT seq 1374 nt   +upstreamnt  +downstreamnt
atggagccctggcctctcctcctgctctttagcctttgctcagctggcctcgtcctgggc
tccgaacatgagacccgtctggtggcaaagctatttaaagactacagcagcgtggtgcgg
ccagtggaagaccaccgccaggtcgtggaggtcaccgtgggcctgcagctgatacagctc
atcaatgtggatgaagtaaatcagatcgtgacaaccaatgtgcgtctgaaacagcaatgg
gtggattacaacctaaaatggaatccagatgactatggcggtgtgaaaaaaattcacatt
ccttcagaaaagatctggcgcccagaccttgttctctataacaatgcagatggtgacttt
gctattgtcaagttcaccaaagtgctcctgcagtacactggccacatcacgtggacacct
ccagccatctttaaaagctactgtgagatcatcgtcacccactttccctttgatgaacag
aactgcagcatgaagctgggcacctggacctacgacggctctgtcgtggccatcaacccg
gaaagcgaccagccagacctgagcaacttcatggagagcggggagtgggtgatcaaggag
tcccggggctggaagcactccgtgacctattcctgctgccccgacaccccctacctggac
atcacctaccacttcgtcatgcagcgcctgcccctctacttcatcgtcaacgtcatcatc
ccctgcctgctcttctccttcttaactggcctggtattctacctgcccacagactcaggg
gagaagatgactctgagcatctctgtcttactgtctttgactgtgttccttctggtcatc
gtggagctgatcccctccacgtccagtgctgtgcccttgattggaaaatacatgctgttc
accatggtgttcgtcattgcctccatcatcatcactgtcatcgtcatcaacacacaccac
cgctcacccagcacccatgtcatgcccaactgggtgcggaaggtttttatcgacactatc
ccaaatatcatgtttttctccacaatgaaaagaccatccagagaaaagcaagacaaaaag
atttttacagaagacattgatatctctgacatttctggaaagccagggcctccacccatg
ggcttccactctcccctgatcaaacaccccgaggtgaaaagtgccatcgagggcatcaag
tacatcgcagagaccatgaagtcagaccaggagtctaacaatgcggcggcagagtggaag
tacgttgcaatggtgatggaccacatactcctcggagtcttcatgcttgtttgcatcatc
ggaaccctagccgtgtttgcaggtcgactcattgaattaaatcagcaaggatga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (6)   
   KEGG DISEASE (2)   
   OMIM (4)   
Drug (13)   
   KEGG DRUG (13)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (9)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (28)   
   RefSeq(nuc) (6)   
   GenBank (11)   
   EMBL (11)   
3D Structure (2)   
   PDB (2)   
Protein domain (4)   
   Pfam (4)   
All databases (84)   

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